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Q3TAE8

- ALG6_MOUSE

UniProt

Q3TAE8 - ALG6_MOUSE

Protein

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

Gene

Alg6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man9GlcNAc(2)-PP-Dol By similarity.By similarity

    Catalytic activityi

    Dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

    Pathwayi

    GO - Molecular functioni

    1. glucosyltransferase activity Source: Ensembl

    GO - Biological processi

    1. protein N-linked glycosylation Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT57. Glycosyltransferase Family 57.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC:2.4.1.267)
    Alternative name(s):
    Asparagine-linked glycosylation protein 6 homolog
    Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
    Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
    Gene namesi
    Name:Alg6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2444031. Alg6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferasePRO_0000284132Add
    BLAST

    Proteomic databases

    PRIDEiQ3TAE8.

    PTM databases

    PhosphoSiteiQ3TAE8.

    Expressioni

    Gene expression databases

    BgeeiQ3TAE8.
    GenevestigatoriQ3TAE8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000095574.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287760.
    GeneTreeiENSGT00550000075073.
    HOGENOMiHOG000195048.
    HOVERGENiHBG024331.
    InParanoidiQ3TAE8.
    KOiK03848.
    OMAiMELTIHL.
    OrthoDBiEOG70088D.
    PhylomeDBiQ3TAE8.
    TreeFamiTF314522.

    Family and domain databases

    InterProiIPR004856. Glyco_trans_ALG6/ALG8.
    [Graphical view]
    PANTHERiPTHR12413. PTHR12413. 1 hit.
    PfamiPF03155. Alg6_Alg8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3TAE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESWPWMAVV VLLGLTVRWT VSLSSYSGAG KPPMFGDYEA QRHWQEITLN    50
    LPVKQWYFNS SDNNLLYWGL DYPPLTAYHS LLCAYVAKFI NPDWVALHTS 100
    RGYESQAHKL FMRATVLAAD LLIYVPAVLL YCYSLKEISP KRKIASALCI 150
    LLYPGLILID YGHFQYNSVS LGFALWGVLG VSWDWDLLGS LAFCLALNYK 200
    QMELYHSLPF FCFLLGKCFK KGLKGKGLAL FIRIACTVLA SFLLCWLPFL 250
    TEREHALQVV RRLFPVDRGL FEDKVANIWC SVNVFLKIKD TLPRHIQIAI 300
    SFCFTLLSLL PACIKLTVRP SCKGFRFTLV SCALSFFLFS FQVHEKSILL 350
    VSLPVCLVLT EIPFMSTWFL LVSTFSMLPL LLKDELLLPS VVTVMAFVIA 400
    CGTFFPMLEN TSEEQLQLKS FAVSVRRHLP GFTFLPRIMQ CLFLSSVITM 450
    VLLTILSVTL DPPQKLPDLF PVLICFVSCV NFVFFLVYFN IVIMWDSKNG 500
    RNRKKIE 507
    Length:507
    Mass (Da):57,874
    Last modified:October 11, 2005 - v1
    Checksum:i55D661178739A2CF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti442 – 4421L → F in BAE34254. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK157903 mRNA. Translation: BAE34254.1.
    AK171887 mRNA. Translation: BAE42720.1.
    BX005053 Genomic DNA. Translation: CAM22176.1.
    BC050854 mRNA. Translation: AAH50854.1.
    CCDSiCCDS38818.1.
    RefSeqiNP_001074733.1. NM_001081264.1.
    UniGeneiMm.32408.

    Genome annotation databases

    EnsembliENSMUST00000097961; ENSMUSP00000095574; ENSMUSG00000073792.
    GeneIDi320438.
    KEGGimmu:320438.
    UCSCiuc008tuw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK157903 mRNA. Translation: BAE34254.1 .
    AK171887 mRNA. Translation: BAE42720.1 .
    BX005053 Genomic DNA. Translation: CAM22176.1 .
    BC050854 mRNA. Translation: AAH50854.1 .
    CCDSi CCDS38818.1.
    RefSeqi NP_001074733.1. NM_001081264.1.
    UniGenei Mm.32408.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000095574.

    Protein family/group databases

    CAZyi GT57. Glycosyltransferase Family 57.

    PTM databases

    PhosphoSitei Q3TAE8.

    Proteomic databases

    PRIDEi Q3TAE8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097961 ; ENSMUSP00000095574 ; ENSMUSG00000073792 .
    GeneIDi 320438.
    KEGGi mmu:320438.
    UCSCi uc008tuw.1. mouse.

    Organism-specific databases

    CTDi 29929.
    MGIi MGI:2444031. Alg6.

    Phylogenomic databases

    eggNOGi NOG287760.
    GeneTreei ENSGT00550000075073.
    HOGENOMi HOG000195048.
    HOVERGENi HBG024331.
    InParanoidi Q3TAE8.
    KOi K03848.
    OMAi MELTIHL.
    OrthoDBi EOG70088D.
    PhylomeDBi Q3TAE8.
    TreeFami TF314522.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 396728.
    PROi Q3TAE8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3TAE8.
    Genevestigatori Q3TAE8.

    Family and domain databases

    InterProi IPR004856. Glyco_trans_ALG6/ALG8.
    [Graphical view ]
    PANTHERi PTHR12413. PTHR12413. 1 hit.
    Pfami PF03155. Alg6_Alg8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiALG6_MOUSE
    AccessioniPrimary (citable) accession number: Q3TAE8
    Secondary accession number(s): Q3TZF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3