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Protein

Zinc finger with UFM1-specific peptidase domain protein

Gene

Zufsp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 24C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 176C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri192 – 214C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger with UFM1-specific peptidase domain protein
Gene namesi
Name:Zufsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919830. Zufsp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443381 – 577Zinc finger with UFM1-specific peptidase domain proteinAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3T9Z9.
PeptideAtlasiQ3T9Z9.
PRIDEiQ3T9Z9.

PTM databases

iPTMnetiQ3T9Z9.
PhosphoSitePlusiQ3T9Z9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039531.
CleanExiMM_ZUFSP.
GenevisibleiQ3T9Z9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037121.

Structurei

3D structure databases

ProteinModelPortaliQ3T9Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili233 – 267Sequence analysisAdd BLAST35

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 24C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 176C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri192 – 214C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4696. Eukaryota.
ENOG410XRQT. LUCA.
GeneTreeiENSGT00390000008232.
HOVERGENiHBG055781.
InParanoidiQ3T9Z9.
OMAiIVHMENE.
OrthoDBiEOG091G09EG.
PhylomeDBiQ3T9Z9.
TreeFamiTF323699.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3T9Z9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSCNICGET VNSEPDMKAH LIVHMENEII CPFCKLSGIN YNEICFHIET
60 70 80 90 100
VHFEQNAPEK NSEKLAAVQY GHSDRKNTNL QSTAEVTSGI HSACASSFPK
110 120 130 140 150
ESSESLPKDR TVKHEAFYTE NITESRKYQK SREKKPGLSE AQGSIYETTY
160 170 180 190 200
SPPECPFCGK IEGCSQDMEI HVKTKHASLL ESPLKDCHQP LYDCPMCGLV
210 220 230 240 250
CTNYHILQEH VDLHLEESSF QQGMDRVQCS SDRELAHRLQ QEEDRKRKSE
260 270 280 290 300
ESRQEREEFQ KLQRQYGLDN SGGYKQQQLR HMELEVNRGR MHPSEFHSRK
310 320 330 340 350
ADMLESIAIG IDDGKTKTSG IIEALHRYYQ NTATDVRCVW LSTVVDHFHS
360 370 380 390 400
SFGDKGWGCG YRNFQMLLSS LLQSDVYGDC LKGMAVPCIP KIQSMIEDAW
410 420 430 440 450
NEGFDPQGAS QLNNKLQGTK AWIGACEIYT LLTSLRVKCR IIDFHKSTGP
460 470 480 490 500
LGTHPRLFEW ILNYYSSETE GTPKIVCTSK PPIYLQHQGH SRTVVGIEEK
510 520 530 540 550
KNRTLCLLVF DPGCPSREMQ KLLKQDMEAS SLRQLRKSVG NLKHKQYQIV
560 570
AVEGVLSPEE KVARKQASQV FTAEKIP
Length:577
Mass (Da):65,593
Last modified:June 27, 2006 - v2
Checksum:i711B6DE1629DFD01
GO
Isoform 2 (identifier: Q3T9Z9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     563-577: ARKQASQVFTAEKIP → VSIG

Note: No experimental confirmation available.
Show »
Length:566
Mass (Da):64,294
Checksum:i434BE6D94791CD0A
GO
Isoform 3 (identifier: Q3T9Z9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-562: Missing.

Note: No experimental confirmation available.
Show »
Length:543
Mass (Da):61,819
Checksum:i8C74D689D1E4DDD5
GO
Isoform 4 (identifier: Q3T9Z9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-279: RQYGLDNSGGYKQQQL → ELLKPSIGIIRTLPQM
     280-577: Missing.

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):31,895
Checksum:iAFA1E1DD4A76603E
GO

Sequence cautioni

The sequence BAC36984 differs from that shown. Reason: Frameshift at position 500.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5N → D in BAE42871 (PubMed:16141072).Curated1
Sequence conflicti50T → A in AAH89514 (PubMed:15489334).Curated1
Sequence conflicti182S → I in BAC36739 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019534264 – 279RQYGL…KQQQL → ELLKPSIGIIRTLPQM in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019535280 – 577Missing in isoform 4. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_019536529 – 562Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_019537563 – 577ARKQA…AEKIP → VSIG in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012263 mRNA. Translation: BAB28126.1.
AK046191 mRNA. Translation: BAC32628.1.
AK052071 mRNA. Translation: BAC34846.1.
AK077304 mRNA. Translation: BAC36739.1.
AK077730 mRNA. Translation: BAC36984.1. Frameshift.
AK172184 mRNA. Translation: BAE42871.1.
BC067065 mRNA. Translation: AAH67065.1.
BC089514 mRNA. Translation: AAH89514.1.
CCDSiCCDS23772.1. [Q3T9Z9-2]
RefSeqiNP_082563.1. NM_028287.2. [Q3T9Z9-2]
XP_006512930.1. XM_006512867.3. [Q3T9Z9-1]
XP_006512931.1. XM_006512868.3. [Q3T9Z9-1]
XP_006512932.1. XM_006512869.3. [Q3T9Z9-1]
XP_006512933.1. XM_006512870.3. [Q3T9Z9-1]
UniGeneiMm.248081.
Mm.479929.

Genome annotation databases

EnsembliENSMUST00000048222; ENSMUSP00000037121; ENSMUSG00000039531. [Q3T9Z9-2]
GeneIDi72580.
KEGGimmu:72580.
UCSCiuc007euj.1. mouse. [Q3T9Z9-3]
uc007euk.1. mouse. [Q3T9Z9-1]
uc007eum.1. mouse. [Q3T9Z9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012263 mRNA. Translation: BAB28126.1.
AK046191 mRNA. Translation: BAC32628.1.
AK052071 mRNA. Translation: BAC34846.1.
AK077304 mRNA. Translation: BAC36739.1.
AK077730 mRNA. Translation: BAC36984.1. Frameshift.
AK172184 mRNA. Translation: BAE42871.1.
BC067065 mRNA. Translation: AAH67065.1.
BC089514 mRNA. Translation: AAH89514.1.
CCDSiCCDS23772.1. [Q3T9Z9-2]
RefSeqiNP_082563.1. NM_028287.2. [Q3T9Z9-2]
XP_006512930.1. XM_006512867.3. [Q3T9Z9-1]
XP_006512931.1. XM_006512868.3. [Q3T9Z9-1]
XP_006512932.1. XM_006512869.3. [Q3T9Z9-1]
XP_006512933.1. XM_006512870.3. [Q3T9Z9-1]
UniGeneiMm.248081.
Mm.479929.

3D structure databases

ProteinModelPortaliQ3T9Z9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037121.

PTM databases

iPTMnetiQ3T9Z9.
PhosphoSitePlusiQ3T9Z9.

Proteomic databases

PaxDbiQ3T9Z9.
PeptideAtlasiQ3T9Z9.
PRIDEiQ3T9Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048222; ENSMUSP00000037121; ENSMUSG00000039531. [Q3T9Z9-2]
GeneIDi72580.
KEGGimmu:72580.
UCSCiuc007euj.1. mouse. [Q3T9Z9-3]
uc007euk.1. mouse. [Q3T9Z9-1]
uc007eum.1. mouse. [Q3T9Z9-2]

Organism-specific databases

CTDi221302.
MGIiMGI:1919830. Zufsp.

Phylogenomic databases

eggNOGiKOG4696. Eukaryota.
ENOG410XRQT. LUCA.
GeneTreeiENSGT00390000008232.
HOVERGENiHBG055781.
InParanoidiQ3T9Z9.
OMAiIVHMENE.
OrthoDBiEOG091G09EG.
PhylomeDBiQ3T9Z9.
TreeFamiTF323699.

Miscellaneous databases

ChiTaRSiZufsp. mouse.
PROiQ3T9Z9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039531.
CleanExiMM_ZUFSP.
GenevisibleiQ3T9Z9. MM.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZUFSP_MOUSE
AccessioniPrimary (citable) accession number: Q3T9Z9
Secondary accession number(s): Q5FWB1
, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although related to the Ufm1-specific proteases, it lacks the conserved His active site, suggesting that it is probably inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.