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Q3T9Y0

- Q3T9Y0_MOUSE

UniProt

Q3T9Y0 - Q3T9Y0_MOUSE

Protein
Submitted name:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Gene

Pik3cd

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: RefGenome

    GO - Biological processi

    1. B cell activation Source: MGI
    2. B cell homeostasis Source: MGI
    3. cell surface receptor signaling pathway Source: MGI
    4. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    5. phosphatidylinositol-mediated signaling Source: InterPro

    Keywords - Molecular functioni

    KinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformImported
    Gene namesi
    Name:Pik3cdImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1098211. Pik3cd.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: RefGenome
    2. plasma membrane Source: RefGenome

    Expressioni

    Gene expression databases

    GenevestigatoriQ3T9Y0.

    Family & Domainsi

    Sequence similaritiesi

    Contains PI3K/PI4K domain.SAAS annotation
    Contains PIK helical domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00620000087742.
    HOGENOMiHOG000252911.
    HOVERGENiHBG052721.
    InParanoidiQ3T9Y0.
    KOiK00922.
    OMAiQCTFMDS.
    TreeFamiTF102031.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3T9Y0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW     50
    HRAQYEPLFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR 100
    LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA 150
    AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA GLLRVSNRAL LVNVKFEGSE 200
    ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA LQVNGRHEYL 250
    YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 300
    AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG 350
    NEMLCKTVSS SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK 400
    AKKARSTKKK SKKADCPIAW ANLMLFDYKD QLKTGERCLY MWPSVPDEKG 450
    ELLNPAGTVR GNPNTESAAA LVIYLPEVAP HPVYFPALEK ILELGRHGER 500
    GRITEEEQLQ LREILERRGS GELYEHEKDL VWKMRHEVQE HFPEALARLL 550
    LVTKWNKHED VAQLSQMLYL LCSWPELPVL SALELLDFSF PDCYVGSFAI 600
    KSLRKLTDDE LFQYLLQLVQ VLKYESYLDC ELTKFLLGRA LANRKIGHFL 650
    FWHLRSEMHV PSVALRFGLI MEAYCRGSTH HMKVLMKQGE ALSKLKALND 700
    FVKVSSQKTT KPQTKEMMHM CMRQETYMEA LSHLQSPLDP STLLEEVCVE 750
    QCTFMDSKMK PLWIMYSSEE AGSAGNVGII FKNGDDLRQD MLTLQMIQLM 800
    DVLWKQEGLD LRMTPYGCLP TGDRTGLIEV VLHSDTIANI QLNKSNMAAT 850
    AAFNKDALLN WLKSKNPGEA LDRAIEEFTL SCAGYCVATY VLGIGDRHSD 900
    NIMIRESGQL FHIDFGHFLG NFKTKFGINR ERVPFILTYD FVHVIQQGKT 950
    NNSEKFERFR GYCERAYTIL RRHGLLFLHL FALMRAAGLP ELSCSKDIQY 1000
    LKDSLALGKT EEEALKHFRV KFNEALRESW KTKVNWLAHN VSKDNRQ 1047
    Length:1,047
    Mass (Da):120,169
    Last modified:October 11, 2005 - v1
    Checksum:i9A23875D95B5F0A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL607078 Genomic DNA. No translation available.
    AL626808 Genomic DNA. No translation available.
    AK172222 mRNA. Translation: BAE42890.1.
    RefSeqiNP_001025008.2. NM_001029837.2.
    NP_001157521.1. NM_001164049.1.
    XP_006536071.1. XM_006536008.1.
    XP_006538712.1. XM_006538649.1.
    UniGeneiMm.229108.

    Genome annotation databases

    EnsembliENSMUST00000105690; ENSMUSP00000101315; ENSMUSG00000039936.
    ENSMUST00000177654; ENSMUSP00000136045; ENSMUSG00000039936.
    GeneIDi18707.
    KEGGimmu:18707.
    UCSCiuc008vww.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL607078 Genomic DNA. No translation available.
    AL626808 Genomic DNA. No translation available.
    AK172222 mRNA. Translation: BAE42890.1 .
    RefSeqi NP_001025008.2. NM_001029837.2.
    NP_001157521.1. NM_001164049.1.
    XP_006536071.1. XM_006536008.1.
    XP_006538712.1. XM_006538649.1.
    UniGenei Mm.229108.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105690 ; ENSMUSP00000101315 ; ENSMUSG00000039936 .
    ENSMUST00000177654 ; ENSMUSP00000136045 ; ENSMUSG00000039936 .
    GeneIDi 18707.
    KEGGi mmu:18707.
    UCSCi uc008vww.2. mouse.

    Organism-specific databases

    CTDi 5293.
    MGIi MGI:1098211. Pik3cd.

    Phylogenomic databases

    GeneTreei ENSGT00620000087742.
    HOGENOMi HOG000252911.
    HOVERGENi HBG052721.
    InParanoidi Q3T9Y0.
    KOi K00922.
    OMAi QCTFMDS.
    TreeFami TF102031.

    Miscellaneous databases

    ChiTaRSi PIK3CD. mouse.
    NextBioi 294773.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3T9Y0.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR003113. PI3K_adapt-bd_dom.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF02192. PI3K_p85B. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00143. PI3K_p85B. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51544. PI3K_ABD. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (AUG-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3T9Y0_MOUSE
    AccessioniPrimary (citable) accession number: Q3T9Y0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3