Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

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Q3T9Y0 (Q3T9Y0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 77. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Ensembl ENSMUSP00000101315 Ensembl ENSMUSP00000136045

Gene names

Name:

Pik3cd Ensembl ENSMUSP00000101315 MGI 1098211 Ensembl ENSMUSP00000136045

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1047 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PI3K/PI4K domain. SAAS SAAS015433

Contains 1 PIK helical domain. SAAS SAAS018936

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008973 Nucleotide-binding
Molecular function	Kinase SAAS SAAS008973 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from mutant phenotype PubMed 12235209. Source: MGI B cell homeostasis Inferred from mutant phenotype PubMed 12235209. Source: MGI cell surface receptor signaling pathway Inferred from mutant phenotype PubMed 12235209. Source: MGI phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular_component	phosphatidylinositol 3-kinase complex Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome 1-phosphatidylinositol-4-phosphate 3-kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-4,5-bisphosphate 3-kinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q3T9Y0 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 9A23875D95B5F0A6
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FASTA

1,047

120,169

        10         20         30         40         50         60 
MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH 

        70         80         90        100        110        120 
MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREGDRVK KLINSQISLL 

       130        140        150        160        170        180 
IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA 

       190        200        210        220        230        240 
GLLRVSNRAL LVNVKFEGSE ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA 

       250        260        270        280        290        300 
LQVNGRHEYL YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 

       310        320        330        340        350        360 
AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG NEMLCKTVSS 

       370        380        390        400        410        420 
SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK AKKARSTKKK SKKADCPIAW 

       430        440        450        460        470        480 
ANLMLFDYKD QLKTGERCLY MWPSVPDEKG ELLNPAGTVR GNPNTESAAA LVIYLPEVAP 

       490        500        510        520        530        540 
HPVYFPALEK ILELGRHGER GRITEEEQLQ LREILERRGS GELYEHEKDL VWKMRHEVQE 

       550        560        570        580        590        600 
HFPEALARLL LVTKWNKHED VAQLSQMLYL LCSWPELPVL SALELLDFSF PDCYVGSFAI 

       610        620        630        640        650        660 
KSLRKLTDDE LFQYLLQLVQ VLKYESYLDC ELTKFLLGRA LANRKIGHFL FWHLRSEMHV 

       670        680        690        700        710        720 
PSVALRFGLI MEAYCRGSTH HMKVLMKQGE ALSKLKALND FVKVSSQKTT KPQTKEMMHM 

       730        740        750        760        770        780 
CMRQETYMEA LSHLQSPLDP STLLEEVCVE QCTFMDSKMK PLWIMYSSEE AGSAGNVGII 

       790        800        810        820        830        840 
FKNGDDLRQD MLTLQMIQLM DVLWKQEGLD LRMTPYGCLP TGDRTGLIEV VLHSDTIANI 

       850        860        870        880        890        900 
QLNKSNMAAT AAFNKDALLN WLKSKNPGEA LDRAIEEFTL SCAGYCVATY VLGIGDRHSD 

       910        920        930        940        950        960 
NIMIRESGQL FHIDFGHFLG NFKTKFGINR ERVPFILTYD FVHVIQQGKT NNSEKFERFR 

       970        980        990       1000       1010       1020 
GYCERAYTIL RRHGLLFLHL FALMRAAGLP ELSCSKDIQY LKDSLALGKT EEEALKHFRV 

      1030       1040 
KFNEALRESW KTKVNWLAHN VSKDNRQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. Hayashizaki Y. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NOD EMBL BAE42890.1. Tissue: Activated spleen EMBL BAE42890.1.
[9]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000101315 Ensembl ENSMUSP00000136045.
[10]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000101315.
[11]	Ensembl Submitted (AUG-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000136045.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL607078 Genomic DNA. No translation available. AL626808 Genomic DNA. No translation available. AK172222 mRNA. Translation: BAE42890.1.
IPI	IPI00316677.
RefSeq	NP_001025008.2. NM_001029837.2. NP_001157521.1. NM_001164049.1.
UniGene	Mm.229108.
3D structure databases
SMR	Q3T9Y0. Positions 20-102, 109-1030.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000105690; ENSMUSP00000101315; ENSMUSG00000039936. ENSMUST00000177654; ENSMUSP00000136045; ENSMUSG00000039936.
GeneID	18707.
KEGG	mmu:18707.
UCSC	uc008vww.2. mouse.
Organism-specific databases
CTD	5293.
MGI	MGI:1098211. Pik3cd.
Phylogenomic databases
GeneTree	ENSGT00620000087742.
HOGENOM	HOG000252911.
HOVERGEN	HBG052721.
InParanoid	Q3T9Y0.
KO	K00922.
OMA	ERCLYMW.
Gene expression databases
Genevestigator	Q3T9Y0.
Family and domain databases
Gene3D	1.10.1070.11. 1 hit. 1.25.40.70. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR003113. PI3K_adapt-bd_dom. IPR002420. PI3K_C2_dom. IPR000341. PI3K_Ras-bd_dom. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
PANTHER	PTHR10048. PTHR10048. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF02192. PI3K_p85B. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
SMART	SM00142. PI3K_C2. 1 hit. SM00143. PI3K_p85B. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51544. PI3K_ABD. 1 hit. PS51547. PI3K_C2. 1 hit. PS51546. PI3K_RBD. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PIK3CD. mouse.
NextBio	294773.
SOURCE	Search...

Entry information

Entry name

Q3T9Y0_MOUSE

Accession

Primary (citable) accession number: Q3T9Y0

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information