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Protein

GON-4-like protein

Gene

GON4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
GON-4-like protein
Alternative name(s):
GON-4 homolog
Gene namesi
Name:GON4L
Synonyms:GON4, KIAA1606
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25973. GON4L.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671723.

Polymorphism and mutation databases

BioMutaiGON4L.
DMDMi84029264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22412241GON-4-like proteinPRO_0000197109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061PhosphoserineCombined sources
Modified residuei346 – 3461PhosphoserineCombined sources
Cross-linki534 – 534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei775 – 7751PhosphoserineBy similarity
Modified residuei1268 – 12681PhosphoserineCombined sources
Modified residuei1426 – 14261PhosphoserineCombined sources
Modified residuei1896 – 18961PhosphoserineCombined sources
Modified residuei1902 – 19021PhosphoserineCombined sources
Modified residuei1977 – 19771PhosphoserineCombined sources
Modified residuei2107 – 21071PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3T8J9.
MaxQBiQ3T8J9.
PaxDbiQ3T8J9.
PeptideAtlasiQ3T8J9.
PRIDEiQ3T8J9.

PTM databases

iPTMnetiQ3T8J9.
PhosphoSiteiQ3T8J9.

Expressioni

Gene expression databases

BgeeiENSG00000116580.
ExpressionAtlasiQ3T8J9. baseline and differential.
GenevisibleiQ3T8J9. HS.

Organism-specific databases

HPAiHPA006986.

Interactioni

Subunit structurei

Found in a complex with YY1, SIN3A and HDAC1.By similarity

Protein-protein interaction databases

BioGridi120206. 8 interactions.
IntActiQ3T8J9. 2 interactions.
MINTiMINT-7032153.
STRINGi9606.ENSP00000271883.

Structurei

3D structure databases

ProteinModelPortaliQ3T8J9.
SMRiQ3T8J9. Positions 2125-2210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1624 – 169673PAH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1706 – 177772PAH 2PROSITE-ProRule annotationAdd
BLAST
Domaini2148 – 220154Myb-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni600 – 1339740Required for interaction with YY1, SIN3A AND HDAC1, and transcriptional repression activityBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 2484Poly-Lys
Compositional biasi448 – 4547Poly-Pro
Compositional biasi517 – 57660Asp-richAdd
BLAST
Compositional biasi1449 – 1569121Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 Myb-like domain.PROSITE-ProRule annotation
Contains 2 PAH (paired amphipathic helix) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHDM. Eukaryota.
ENOG410XS4M. LUCA.
GeneTreeiENSGT00390000016256.
HOVERGENiHBG081563.
InParanoidiQ3T8J9.
OMAiEKVKPQS.
OrthoDBiEOG091G02EQ.
PhylomeDBiQ3T8J9.
TreeFamiTF343327.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.20.1160.11. 1 hit.
InterProiIPR033277. GON-4-like.
IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR003822. PAH.
[Graphical view]
PANTHERiPTHR16088:SF11. PTHR16088:SF11. 2 hits.
PfamiPF02671. PAH. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47762. SSF47762. 2 hits.
PROSITEiPS50090. MYB_LIKE. 1 hit.
PS51477. PAH. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3T8J9-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD
60 70 80 90 100
PSHGRVAGFE VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS
110 120 130 140 150
QGITLPSLES FHPLNIHIGK GKLHATGSKR GKKMTLRPGP VTQEDRCDHL
160 170 180 190 200
TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP SLPSGSQSAK PVSQPRKSTQ
210 220 230 240 250
PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES EKRRKKKKGT
260 270 280 290 300
KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT
310 320 330 340 350
NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK
360 370 380 390 400
ANEIKPPQFV DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS
410 420 430 440 450
PRGAKKSRLR QSSEMTETDE ESGILSEAEK VTTPAIRHIS AEVVPMGPPP
460 470 480 490 500
PPKPKQTRDS TFMEKLHAVD EELASSPVCM DSFQPMDDSL IAFRTRSKMP
510 520 530 540 550
LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL MNDDVGNEDE
560 570 580 590 600
ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE
610 620 630 640 650
MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL
660 670 680 690 700
FEQLKMKKSS AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ
710 720 730 740 750
LLTQIHLLAT CNPNLNPEAT TTRIFLKELG TFAQSSIALH HQYNPKFQTL
760 770 780 790 800
FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV KKTANEFPCL PKQVAWILAT
810 820 830 840 850
SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH FEGTEFPNPL
860 870 880 890 900
ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI
910 920 930 940 950
QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI
960 970 980 990 1000
NSDRSLEKDN LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV
1010 1020 1030 1040 1050
LKPLLIQPSP SLQPSFNPGK TPARSTHSEA PPSKMVLRIP HPIQPATVLQ
1060 1070 1080 1090 1100
TVPGVPPLGV SGGESFESPA ALPAVPPEAR TSFPLSESQT LLSSAPVPKV
1110 1120 1130 1140 1150
MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP ASVIFTVPAT
1160 1170 1180 1190 1200
TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA
1210 1220 1230 1240 1250
SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE
1260 1270 1280 1290 1300
PQELSPLSAT VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ
1310 1320 1330 1340 1350
ALEPLPQGIQ ESLNNPTPGD LEEIVKMEPE EAREEISGSP ERDICDDIKV
1360 1370 1380 1390 1400
EHAVELDTGA PSEELSSAGE VTKQTVLQKE EERSQPTKTP SSSQEPPDEG
1410 1420 1430 1440 1450
TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ SVGTPVGPET
1460 1470 1480 1490 1500
GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL
1510 1520 1530 1540 1550
ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG
1560 1570 1580 1590 1600
DSAEKPPTFA SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR
1610 1620 1630 1640 1650
ASKDTSKLLL LYDEDILERD PLREQKDLAF AQAYLTRVRE ALQHIPGKYE
1660 1670 1680 1690 1700
DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ DWPQLLKDFA AFLLPEQALA
1710 1720 1730 1740 1750
CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG CADCLPQEIT
1760 1770 1780 1790 1800
ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF
1810 1820 1830 1840 1850
DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC
1860 1870 1880 1890 1900
ACSCHEGGPD SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE
1910 1920 1930 1940 1950
ASPMPGAKEA GQGKDMMEEE APEERESTEA TQSRTVRTTR KGEMPVSAGL
1960 1970 1980 1990 2000
AVGSTLPSPR EVTVTERLLL DGPPPHSPET PQFPPTTGAV LYTVKRNQVG
2010 2020 2030 2040 2050
PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK LPGTVEPPAS
2060 2070 2080 2090 2100
FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG
2110 2120 2130 2140 2150
IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG
2160 2170 2180 2190 2200
EKVVLWTREA DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL
2210 2220 2230 2240
MQLFHTACEA SSEDEDDATS TSNADQLSDH GDLLSEEELD E
Length:2,241
Mass (Da):248,620
Last modified:October 11, 2005 - v1
Checksum:i07959F5B5E832DC7
GO
Isoform 2 (identifier: Q3T8J9-2) [UniParc]FASTAAdd to basket
Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
     1492-1529: ETMEKLTWLA...ENSEPEEEEE → VRAGEYSQVF...TMDSPKIICI
     1530-2241: Missing.

Show »
Length:1,529
Mass (Da):169,107
Checksum:i3813E51701483286
GO
Isoform 3 (identifier: Q3T8J9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1948-1948: Missing.

Show »
Length:2,240
Mass (Da):248,549
Checksum:iF9278C03C9382D21
GO

Sequence cautioni

The sequence CAD97829 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH10549 differs from that shown. Reason: Erroneous termination at position 1114. Translated as Tyr.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti433 – 4331T → A in AAR01262 (Ref. 1) Curated
Sequence conflicti433 – 4331T → A in CAD97829 (PubMed:11230166).Curated
Sequence conflicti626 – 6261T → A in CAH10549 (PubMed:11230166).Curated
Sequence conflicti988 – 9881F → S in AAR01262 (Ref. 1) Curated
Sequence conflicti988 – 9881F → S in CAD97829 (PubMed:11230166).Curated
Sequence conflicti1150 – 11501T → S in CAH10549 (PubMed:11230166).Curated
Sequence conflicti1299 – 12991R → G in CAH10549 (PubMed:11230166).Curated
Sequence conflicti1382 – 13821E → G in AAR01262 (Ref. 1) Curated
Sequence conflicti1382 – 13821E → G in CAD97829 (PubMed:11230166).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501L → F.
Corresponds to variant rs3738586 [ dbSNP | Ensembl ].
VAR_056169
Natural varianti416 – 4161T → A.
Corresponds to variant rs34939643 [ dbSNP | Ensembl ].
VAR_056170
Natural varianti1197 – 11971S → P.
Corresponds to variant rs676814 [ dbSNP | Ensembl ].
VAR_056171
Natural varianti1418 – 14181M → V.1 Publication
Corresponds to variant rs2297775 [ dbSNP | Ensembl ].
VAR_024320
Natural varianti1539 – 15391Q → E.
Corresponds to variant rs607790 [ dbSNP | Ensembl ].
VAR_056172

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1492 – 152938ETMEK…EEEEE → VRAGEYSQVFRGLSNMYHLL ICHLLACCTMDSPKIICI in isoform 2. 3 PublicationsVSP_016580Add
BLAST
Alternative sequencei1530 – 2241712Missing in isoform 2. 3 PublicationsVSP_016581Add
BLAST
Alternative sequencei1948 – 19481Missing in isoform 3. 2 PublicationsVSP_016582

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335490 mRNA. Translation: AAR01260.1.
AY335491 mRNA. Translation: AAR01261.1.
AY335492 mRNA. Translation: AAR01262.1.
AL136565 mRNA. Translation: CAB66500.2.
BX537764 mRNA. Translation: CAD97829.1. Different initiation.
BX648043 mRNA. Translation: CAH10549.1. Different termination.
AL139128 Genomic DNA. Translation: CAH69947.1.
AL162734, AL139128 Genomic DNA. Translation: CAX15001.1.
AL139128, AL162734 Genomic DNA. Translation: CAX15049.1.
CH471121 Genomic DNA. Translation: EAW53029.1.
CH471121 Genomic DNA. Translation: EAW53030.1.
BC036740 mRNA. Translation: AAH36740.2.
BC064933 mRNA. Translation: AAH64933.1.
BC114629 mRNA. Translation: AAI14630.1.
AB046826 mRNA. Translation: BAB13432.1.
CCDSiCCDS1121.1. [Q3T8J9-2]
CCDS44242.1. [Q3T8J9-3]
CCDS60296.1. [Q3T8J9-1]
RefSeqiNP_001269785.1. NM_001282856.1. [Q3T8J9-1]
NP_001269787.1. NM_001282858.1. [Q3T8J9-3]
NP_001269789.1. NM_001282860.1. [Q3T8J9-1]
NP_001269790.1. NM_001282861.1. [Q3T8J9-2]
NP_115668.4. NM_032292.5. [Q3T8J9-2]
XP_006711456.1. XM_006711393.3. [Q3T8J9-3]
XP_006711457.1. XM_006711394.3. [Q3T8J9-3]
UniGeneiHs.656361.

Genome annotation databases

EnsembliENST00000271883; ENSP00000271883; ENSG00000116580. [Q3T8J9-3]
ENST00000361040; ENSP00000354322; ENSG00000116580. [Q3T8J9-2]
ENST00000368331; ENSP00000357315; ENSG00000116580. [Q3T8J9-1]
ENST00000437809; ENSP00000396117; ENSG00000116580. [Q3T8J9-3]
ENST00000615926; ENSP00000483100; ENSG00000116580. [Q3T8J9-1]
GeneIDi54856.
KEGGihsa:54856.
UCSCiuc001flz.4. human. [Q3T8J9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

GON4L entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335490 mRNA. Translation: AAR01260.1.
AY335491 mRNA. Translation: AAR01261.1.
AY335492 mRNA. Translation: AAR01262.1.
AL136565 mRNA. Translation: CAB66500.2.
BX537764 mRNA. Translation: CAD97829.1. Different initiation.
BX648043 mRNA. Translation: CAH10549.1. Different termination.
AL139128 Genomic DNA. Translation: CAH69947.1.
AL162734, AL139128 Genomic DNA. Translation: CAX15001.1.
AL139128, AL162734 Genomic DNA. Translation: CAX15049.1.
CH471121 Genomic DNA. Translation: EAW53029.1.
CH471121 Genomic DNA. Translation: EAW53030.1.
BC036740 mRNA. Translation: AAH36740.2.
BC064933 mRNA. Translation: AAH64933.1.
BC114629 mRNA. Translation: AAI14630.1.
AB046826 mRNA. Translation: BAB13432.1.
CCDSiCCDS1121.1. [Q3T8J9-2]
CCDS44242.1. [Q3T8J9-3]
CCDS60296.1. [Q3T8J9-1]
RefSeqiNP_001269785.1. NM_001282856.1. [Q3T8J9-1]
NP_001269787.1. NM_001282858.1. [Q3T8J9-3]
NP_001269789.1. NM_001282860.1. [Q3T8J9-1]
NP_001269790.1. NM_001282861.1. [Q3T8J9-2]
NP_115668.4. NM_032292.5. [Q3T8J9-2]
XP_006711456.1. XM_006711393.3. [Q3T8J9-3]
XP_006711457.1. XM_006711394.3. [Q3T8J9-3]
UniGeneiHs.656361.

3D structure databases

ProteinModelPortaliQ3T8J9.
SMRiQ3T8J9. Positions 2125-2210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120206. 8 interactions.
IntActiQ3T8J9. 2 interactions.
MINTiMINT-7032153.
STRINGi9606.ENSP00000271883.

PTM databases

iPTMnetiQ3T8J9.
PhosphoSiteiQ3T8J9.

Polymorphism and mutation databases

BioMutaiGON4L.
DMDMi84029264.

Proteomic databases

EPDiQ3T8J9.
MaxQBiQ3T8J9.
PaxDbiQ3T8J9.
PeptideAtlasiQ3T8J9.
PRIDEiQ3T8J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271883; ENSP00000271883; ENSG00000116580. [Q3T8J9-3]
ENST00000361040; ENSP00000354322; ENSG00000116580. [Q3T8J9-2]
ENST00000368331; ENSP00000357315; ENSG00000116580. [Q3T8J9-1]
ENST00000437809; ENSP00000396117; ENSG00000116580. [Q3T8J9-3]
ENST00000615926; ENSP00000483100; ENSG00000116580. [Q3T8J9-1]
GeneIDi54856.
KEGGihsa:54856.
UCSCiuc001flz.4. human. [Q3T8J9-1]

Organism-specific databases

CTDi54856.
GeneCardsiGON4L.
H-InvDBHIX0001135.
HIX0028547.
HGNCiHGNC:25973. GON4L.
HPAiHPA006986.
MIMi610393. gene.
neXtProtiNX_Q3T8J9.
PharmGKBiPA142671723.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDM. Eukaryota.
ENOG410XS4M. LUCA.
GeneTreeiENSGT00390000016256.
HOVERGENiHBG081563.
InParanoidiQ3T8J9.
OMAiEKVKPQS.
OrthoDBiEOG091G02EQ.
PhylomeDBiQ3T8J9.
TreeFamiTF343327.

Miscellaneous databases

GeneWikiiGON4L.
GenomeRNAii54856.
PROiQ3T8J9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116580.
ExpressionAtlasiQ3T8J9. baseline and differential.
GenevisibleiQ3T8J9. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.20.1160.11. 1 hit.
InterProiIPR033277. GON-4-like.
IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR003822. PAH.
[Graphical view]
PANTHERiPTHR16088:SF11. PTHR16088:SF11. 2 hits.
PfamiPF02671. PAH. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47762. SSF47762. 2 hits.
PROSITEiPS50090. MYB_LIKE. 1 hit.
PS51477. PAH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGON4L_HUMAN
AccessioniPrimary (citable) accession number: Q3T8J9
Secondary accession number(s): B7ZBL4
, Q14C93, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.