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Q3T4C0

- COX2_SMICU

UniProt

Q3T4C0 - COX2_SMICU

Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Smittium culisetae (Gut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.Curated

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

    Cofactori

    Copper A.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi182 – 1821Copper ABy similarity
    Metal bindingi217 – 2171Copper ABy similarity
    Metal bindingi221 – 2211Copper ABy similarity
    Metal bindingi225 – 2251Copper ABy similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2By similarity (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide IIBy similarity
    Gene namesi
    Name:cox2Imported
    Encoded oniMitochondrionImported
    OrganismiSmittium culisetae (Gut fungus)
    Taxonomic identifieri1213189 [NCBI]
    Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesKickxellomycotinaHarpellalesLegeriomycetaceaeZancudomyces

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Cytochrome c oxidase subunit 2PRO_0000393948Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ3T4C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini12 – 3827Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini60 – 7314Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini95 – 248154Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3T4C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIFSFYIIN NDAPEPWQIC YQDSATKIMS GIDKLTGEIF YYETLLLIIV    50
    GWVLISAIIK YTKTELSYKY FNHGTLIEIL WTCSPAFILI AISFPSFKLL 100
    YLMDSIIDSQ ITIKVLGHQW YWSYEYSDYL DNSGDSISFD SIMIPTDDLE 150
    PGQFRLLEVD NRIVLPIHTH IRFICTSSDV IHSFAVPSLG LKIDALPGRL 200
    NGISTYVERE GTFYGQCSEL CGVYHFGMPI VIEAVRIEKY LEWLNIHLDN 250
    TPSS 254
    Length:254
    Mass (Da):29,146
    Last modified:October 11, 2005 - v1
    Checksum:i49F6B1CABBD940C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY863213 Genomic DNA. Translation: AAW49494.1.
    RefSeqiYP_203327.1. NC_006837.1.

    Genome annotation databases

    GeneIDi3260112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY863213 Genomic DNA. Translation: AAW49494.1 .
    RefSeqi YP_203327.1. NC_006837.1.

    3D structure databases

    ProteinModelPortali Q3T4C0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3260112.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative mitochondrial genomics in zygomycetes: bacteria-like RNase P RNAs, mobile elements, and a close source of the group I intron invasion in angiosperms."
      Seif E., Leigh J., Liu Y., Roewer I., Forget L., Lang B.F.
      Nucleic Acids Res. 33:734-744(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 18-3Imported.

    Entry informationi

    Entry nameiCOX2_SMICU
    AccessioniPrimary (citable) accession number: Q3T4C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3