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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Zancudomyces culisetae (Gut fungus) (Smittium culisetae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

Cofactori

Cu cationCuratedNote: Binds a copper A center.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182Copper ABy similarity1
Metal bindingi217Copper ABy similarity1
Metal bindingi221Copper ABy similarity1
Metal bindingi225Copper ABy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2By similarity (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide IIBy similarity
Gene namesi
Name:cox2Imported
Encoded oniMitochondrionImported
OrganismiZancudomyces culisetae (Gut fungus) (Smittium culisetae)
Taxonomic identifieri1213189 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisZoopagomycotaKickxellomycotinaHarpellalesLegeriomycetaceaeZancudomyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini12 – 38Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 73Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 248Mitochondrial intermembraneSequence analysisAdd BLAST154

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939481 – 254Cytochrome c oxidase subunit 2Add BLAST254

Structurei

3D structure databases

ProteinModelPortaliQ3T4C0
SMRiQ3T4C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T4C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFSFYIIN NDAPEPWQIC YQDSATKIMS GIDKLTGEIF YYETLLLIIV
60 70 80 90 100
GWVLISAIIK YTKTELSYKY FNHGTLIEIL WTCSPAFILI AISFPSFKLL
110 120 130 140 150
YLMDSIIDSQ ITIKVLGHQW YWSYEYSDYL DNSGDSISFD SIMIPTDDLE
160 170 180 190 200
PGQFRLLEVD NRIVLPIHTH IRFICTSSDV IHSFAVPSLG LKIDALPGRL
210 220 230 240 250
NGISTYVERE GTFYGQCSEL CGVYHFGMPI VIEAVRIEKY LEWLNIHLDN

TPSS
Length:254
Mass (Da):29,146
Last modified:October 11, 2005 - v1
Checksum:i49F6B1CABBD940C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863213 Genomic DNA Translation: AAW49494.1
RefSeqiYP_203327.1, NC_006837.1

Genome annotation databases

GeneIDi3260112

Similar proteinsi

Entry informationi

Entry nameiCOX2_ZANCU
AccessioniPrimary (citable) accession number: Q3T4C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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