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Q3T4C0 (COX2_SMICU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox2
Encoded onMitochondrion
OrganismSmittium culisetae (Gut fungus)
Taxonomic identifier1213189 [NCBI]
Taxonomic lineageEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesKickxellomycotinaHarpellalesLegeriomycetaceaeZancudomyces

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Cytochrome c oxidase subunit 2
PRO_0000393948

Regions

Topological domain12 – 3827Mitochondrial intermembrane Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 7314Mitochondrial matrix Potential
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 248154Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A By similarity UniProtKB Q0H8Y7
Metal binding2171Copper A By similarity UniProtKB Q0H8Y7
Metal binding2211Copper A By similarity UniProtKB Q0H8Y7
Metal binding2251Copper A By similarity UniProtKB Q0H8Y7

Sequences

Sequence LengthMass (Da)Tools
Q3T4C0 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 49F6B1CABBD940C0

FASTA25429,146
        10         20         30         40         50         60 
MNIFSFYIIN NDAPEPWQIC YQDSATKIMS GIDKLTGEIF YYETLLLIIV GWVLISAIIK 

        70         80         90        100        110        120 
YTKTELSYKY FNHGTLIEIL WTCSPAFILI AISFPSFKLL YLMDSIIDSQ ITIKVLGHQW 

       130        140        150        160        170        180 
YWSYEYSDYL DNSGDSISFD SIMIPTDDLE PGQFRLLEVD NRIVLPIHTH IRFICTSSDV 

       190        200        210        220        230        240 
IHSFAVPSLG LKIDALPGRL NGISTYVERE GTFYGQCSEL CGVYHFGMPI VIEAVRIEKY 

       250 
LEWLNIHLDN TPSS 

« Hide

References

[1]"Comparative mitochondrial genomics in zygomycetes: bacteria-like RNase P RNAs, mobile elements, and a close source of the group I intron invasion in angiosperms."
Seif E., Leigh J., Liu Y., Roewer I., Forget L., Lang B.F.
Nucleic Acids Res. 33:734-744(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 18-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY863213 Genomic DNA. Translation: AAW49494.1.
RefSeqYP_203327.1. NC_006837.1.

3D structure databases

ProteinModelPortalQ3T4C0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3260112.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_SMICU
AccessionPrimary (citable) accession number: Q3T4C0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families