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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Zancudomyces culisetae (Gut fungus) (Smittium culisetae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

Cofactori

Cu cationCuratedNote: Binds a copper A center.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182Copper ABy similarity1
Metal bindingi217Copper ABy similarity1
Metal bindingi221Copper ABy similarity1
Metal bindingi225Copper ABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2By similarity (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide IIBy similarity
Gene namesi
Name:cox2Imported
Encoded oniMitochondrionImported
OrganismiZancudomyces culisetae (Gut fungus) (Smittium culisetae)
Taxonomic identifieri1213189 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisKickxellomycotinaHarpellalesLegeriomycetaceaeZancudomyces

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini12 – 38Mitochondrial intermembraneSequence analysisAdd BLAST27
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 73Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 248Mitochondrial intermembraneSequence analysisAdd BLAST154

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939481 – 254Cytochrome c oxidase subunit 2Add BLAST254

Structurei

3D structure databases

ProteinModelPortaliQ3T4C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T4C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFSFYIIN NDAPEPWQIC YQDSATKIMS GIDKLTGEIF YYETLLLIIV
60 70 80 90 100
GWVLISAIIK YTKTELSYKY FNHGTLIEIL WTCSPAFILI AISFPSFKLL
110 120 130 140 150
YLMDSIIDSQ ITIKVLGHQW YWSYEYSDYL DNSGDSISFD SIMIPTDDLE
160 170 180 190 200
PGQFRLLEVD NRIVLPIHTH IRFICTSSDV IHSFAVPSLG LKIDALPGRL
210 220 230 240 250
NGISTYVERE GTFYGQCSEL CGVYHFGMPI VIEAVRIEKY LEWLNIHLDN

TPSS
Length:254
Mass (Da):29,146
Last modified:October 11, 2005 - v1
Checksum:i49F6B1CABBD940C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863213 Genomic DNA. Translation: AAW49494.1.
RefSeqiYP_203327.1. NC_006837.1.

Genome annotation databases

GeneIDi3260112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY863213 Genomic DNA. Translation: AAW49494.1.
RefSeqiYP_203327.1. NC_006837.1.

3D structure databases

ProteinModelPortaliQ3T4C0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3260112.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_ZANCU
AccessioniPrimary (citable) accession number: Q3T4C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: October 11, 2005
Last modified: January 20, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.