Q3T4C0 (COX2_SMICU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

cox2

Encoded on

Mitochondrion

Organism

Smittium culisetae (Gut fungus)

Taxonomic identifier

1213189 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Fungi incertae sedis › Early diverging fungal lineages › Kickxellomycotina › Harpellales › Legeriomycetaceae › Zancudomyces

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Cytochrome c oxidase subunit 2		PRO_0000393948
Regions
	Topological domain	12 – 38	27	Mitochondrial intermembrane Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 73	14	Mitochondrial matrix Potential
	Transmembrane	74 – 94	21	Helical; Potential
	Topological domain	95 – 248	154	Mitochondrial intermembrane Potential
Sites
	Metal binding	182	1	Copper A By similarity UniProtKB Q0H8Y7
	Metal binding	217	1	Copper A By similarity UniProtKB Q0H8Y7
	Metal binding	221	1	Copper A By similarity UniProtKB Q0H8Y7
	Metal binding	225	1	Copper A By similarity UniProtKB Q0H8Y7

Sequences

	Sequence		Length	Mass (Da)
	Q3T4C0 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 49F6B1CABBD940C0	FASTA	254	29,146
	10 20 30 40 50 60 MNIFSFYIIN NDAPEPWQIC YQDSATKIMS GIDKLTGEIF YYETLLLIIV GWVLISAIIK 70 80 90 100 110 120 YTKTELSYKY FNHGTLIEIL WTCSPAFILI AISFPSFKLL YLMDSIIDSQ ITIKVLGHQW 130 140 150 160 170 180 YWSYEYSDYL DNSGDSISFD SIMIPTDDLE PGQFRLLEVD NRIVLPIHTH IRFICTSSDV 190 200 210 220 230 240 IHSFAVPSLG LKIDALPGRL NGISTYVERE GTFYGQCSEL CGVYHFGMPI VIEAVRIEKY 250 LEWLNIHLDN TPSS

References

[1]

"Comparative mitochondrial genomics in zygomycetes: bacteria-like RNase P RNAs, mobile elements, and a close source of the group I intron invasion in angiosperms." Seif E., Leigh J., Liu Y., Roewer I., Forget L., Lang B.F. Nucleic Acids Res. 33:734-744(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 18-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY863213 Genomic DNA. Translation: AAW49494.1.
RefSeq	YP_203327.1. NC_006837.1.
3D structure databases
ProteinModelPortal	Q3T4C0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3260112.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_SMICU

Accession

Primary (citable) accession number: Q3T4C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 18, 2010
Last sequence update:	October 11, 2005
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program