Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Integrin alpha L

Gene

Itgal

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • single organismal cell-cell adhesion Source: RGD

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha LImported
Gene namesi
Name:ItgalImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi631424. Itgal.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1085 – 1107HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500142581324 – 1160UniRule annotationAdd BLAST1137

Proteomic databases

PaxDbiQ3T1L6.

PTM databases

iPTMnetiQ3T1L6.
PhosphoSitePlusiQ3T1L6.

Expressioni

Gene expression databases

GenevisibleiQ3T1L6. RN.

Interactioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein heterodimerization activity Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ3T1L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 79FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati80 – 137FG-GAPPROSITE-ProRule annotationAdd BLAST58
Domaini152 – 324VWFAInterPro annotationAdd BLAST173
Repeati335 – 386FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati389 – 442FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati443 – 503FG-GAPPROSITE-ProRule annotationAdd BLAST61
Repeati504 – 560FG-GAPPROSITE-ProRule annotationAdd BLAST57
Repeati564 – 624FG-GAPPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG006188.
KOiK05718.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
PfamiView protein in Pfam
PF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3T1L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRIPGPRL LLLGLQLFVN AWSYNLDTRH AQSFLTQAGR HFGYQVLQFG
60 70 80 90 100
DGVVVGAPGE GNSTGNLYHC HPSSGSCQPV HLGSNHTSKY LGMTMVTDAA
110 120 130 140 150
KGSLLACDPG LSRTCDQNPY LSGLCYLFSQ SLGKPILQNR PAYQECMKGN
160 170 180 190 200
VDLVFLFDGS QSLDKKDFEK IVDFMKDVMR KLSNTSYQFA AVQFSTECKT
210 220 230 240 250
EFTFLDYIKL NKNPDVLLGN VTPMFLLTNT FRAINYVVTH VFKEESGARP
260 270 280 290 300
DATKVLVIIT DGEASDNGNI DAAQDITRYI IGIGKHFSTT QKQEKLHIFA
310 320 330 340 350
SKPVEEFVKI LDTFEKLKDL FTDLQRKIYA IEGTSKQDLA SFNMELSSSG
360 370 380 390 400
ISADLSKGHA VVGAVGAKDW AGGFLDLHED LEGATFVGQE PLTSDERGGY
410 420 430 440 450
LGYTVAWLTS RSSRPLLAAG APRYQHVGQV LLFQAPEAGG HWNQTQKIEG
460 470 480 490 500
TQIGSYFGGE LCSVDLHQDG ETDLLLIGAP LFYGEQRGGR VSVYQRRRSL
510 520 530 540 550
FEMVSELQGD PGYPLGRFGA AISALTDING DGLTDVAVGA PLEEQGAVYI
560 570 580 590 600
FNGKPGGFSS QSSQRIPGTQ VSPGVRWFGR SIHGVKDLGG DRLADVVVGA
610 620 630 640 650
EGQVIVLSSR PVVDIVTELS FSPDEIPVHE VECSYSASQE QKEGVKLKVC
660 670 680 690 700
FQIRPLTSQF QGRLLANLSY TLQLDGHRTR SRGLFPGGSR ELGGNTFVTP
710 720 730 740 750
DRSCMDFHFH FPICIQDLIS PINVSLNFSL LEEEGSPRDQ KGGRDMQPIL
760 770 780 790 800
RPSIHAVTKE IPFEKNCGED KKCEADLALS PPARSGVLRL MSSASLAVEW
810 820 830 840 850
TLRNLGEDAY WVRLDLDFPR GLSFRKVEML QPHSQIPVSC EELTEESSLL
860 870 880 890 900
TKTLKCNVSS PIFKAGKQMT LQVMFNTLLN SSWGDFVELN GTVHCENENS
910 920 930 940 950
SLGKDNSATT RIPVLYPVNI LTEDQENSTL YISFTPKGPK TQQVQHIYKV
960 970 980 990 1000
RIQPSAYDHN MPALEALVEV PQPHSEGPIA HTWTVHTDPL VTCHCEDLKK
1010 1020 1030 1040 1050
PTREAEPCLP GVQFRCPIVF RQETFIRVAG TVELSEKIKA SSTLSLCSSL
1060 1070 1080 1090 1100
SVSFNSSKHF HLYGSKASKA QVLMKVDMIY EKEMLHLYVL SGIGGLLLLS
1110 1120 1130 1140 1150
LIFLALYKVG FFKRKLKEKM EADGGVPNGS PGEDADPLAV PGEETKDMGC
1160
LEPLRESDKD
Length:1,160
Mass (Da):127,591
Last modified:October 11, 2005 - v1
Checksum:i92138CDC6B7FEA00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101849 mRNA. Translation: AAI01850.1.
RefSeqiNP_001029170.1. NM_001033998.2.
UniGeneiRn.14655.

Genome annotation databases

GeneIDi308995.
KEGGirno:308995.

Similar proteinsi

Entry informationi

Entry nameiQ3T1L6_RAT
AccessioniPrimary (citable) accession number: Q3T1L6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)