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Protein
Submitted name:

Integrin alpha L

Gene

Itgal

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • single organismal cell-cell adhesion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha LImported
Gene namesi
Name:ItgalImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi631424. Itgal.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1085 – 110723HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323UniRule annotationAdd
BLAST
Chaini24 – 11601137UniRule annotationPRO_5001425813Add
BLAST

Proteomic databases

PaxDbiQ3T1L6.
PRIDEiQ3T1L6.

PTM databases

iPTMnetiQ3T1L6.
PhosphoSiteiQ3T1L6.

Expressioni

Gene expression databases

GenevisibleiQ3T1L6. RN.

Interactioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024404.

Structurei

3D structure databases

ProteinModelPortaliQ3T1L6.
SMRiQ3T1L6. Positions 148-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 324173VWFAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation
Contains FG-GAP repeats.SAAS annotation
Contains VWFA domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG006188.
KOiK05718.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T1L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRIPGPRL LLLGLQLFVN AWSYNLDTRH AQSFLTQAGR HFGYQVLQFG
60 70 80 90 100
DGVVVGAPGE GNSTGNLYHC HPSSGSCQPV HLGSNHTSKY LGMTMVTDAA
110 120 130 140 150
KGSLLACDPG LSRTCDQNPY LSGLCYLFSQ SLGKPILQNR PAYQECMKGN
160 170 180 190 200
VDLVFLFDGS QSLDKKDFEK IVDFMKDVMR KLSNTSYQFA AVQFSTECKT
210 220 230 240 250
EFTFLDYIKL NKNPDVLLGN VTPMFLLTNT FRAINYVVTH VFKEESGARP
260 270 280 290 300
DATKVLVIIT DGEASDNGNI DAAQDITRYI IGIGKHFSTT QKQEKLHIFA
310 320 330 340 350
SKPVEEFVKI LDTFEKLKDL FTDLQRKIYA IEGTSKQDLA SFNMELSSSG
360 370 380 390 400
ISADLSKGHA VVGAVGAKDW AGGFLDLHED LEGATFVGQE PLTSDERGGY
410 420 430 440 450
LGYTVAWLTS RSSRPLLAAG APRYQHVGQV LLFQAPEAGG HWNQTQKIEG
460 470 480 490 500
TQIGSYFGGE LCSVDLHQDG ETDLLLIGAP LFYGEQRGGR VSVYQRRRSL
510 520 530 540 550
FEMVSELQGD PGYPLGRFGA AISALTDING DGLTDVAVGA PLEEQGAVYI
560 570 580 590 600
FNGKPGGFSS QSSQRIPGTQ VSPGVRWFGR SIHGVKDLGG DRLADVVVGA
610 620 630 640 650
EGQVIVLSSR PVVDIVTELS FSPDEIPVHE VECSYSASQE QKEGVKLKVC
660 670 680 690 700
FQIRPLTSQF QGRLLANLSY TLQLDGHRTR SRGLFPGGSR ELGGNTFVTP
710 720 730 740 750
DRSCMDFHFH FPICIQDLIS PINVSLNFSL LEEEGSPRDQ KGGRDMQPIL
760 770 780 790 800
RPSIHAVTKE IPFEKNCGED KKCEADLALS PPARSGVLRL MSSASLAVEW
810 820 830 840 850
TLRNLGEDAY WVRLDLDFPR GLSFRKVEML QPHSQIPVSC EELTEESSLL
860 870 880 890 900
TKTLKCNVSS PIFKAGKQMT LQVMFNTLLN SSWGDFVELN GTVHCENENS
910 920 930 940 950
SLGKDNSATT RIPVLYPVNI LTEDQENSTL YISFTPKGPK TQQVQHIYKV
960 970 980 990 1000
RIQPSAYDHN MPALEALVEV PQPHSEGPIA HTWTVHTDPL VTCHCEDLKK
1010 1020 1030 1040 1050
PTREAEPCLP GVQFRCPIVF RQETFIRVAG TVELSEKIKA SSTLSLCSSL
1060 1070 1080 1090 1100
SVSFNSSKHF HLYGSKASKA QVLMKVDMIY EKEMLHLYVL SGIGGLLLLS
1110 1120 1130 1140 1150
LIFLALYKVG FFKRKLKEKM EADGGVPNGS PGEDADPLAV PGEETKDMGC
1160
LEPLRESDKD
Length:1,160
Mass (Da):127,591
Last modified:October 11, 2005 - v1
Checksum:i92138CDC6B7FEA00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101849 mRNA. Translation: AAI01850.1.
RefSeqiNP_001029170.1. NM_001033998.2.
UniGeneiRn.14655.

Genome annotation databases

GeneIDi308995.
KEGGirno:308995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101849 mRNA. Translation: AAI01850.1.
RefSeqiNP_001029170.1. NM_001033998.2.
UniGeneiRn.14655.

3D structure databases

ProteinModelPortaliQ3T1L6.
SMRiQ3T1L6. Positions 148-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024404.

PTM databases

iPTMnetiQ3T1L6.
PhosphoSiteiQ3T1L6.

Proteomic databases

PaxDbiQ3T1L6.
PRIDEiQ3T1L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi308995.
KEGGirno:308995.

Organism-specific databases

CTDi3683.
RGDi631424. Itgal.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG006188.
KOiK05718.

Gene expression databases

GenevisibleiQ3T1L6. RN.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ProstateImported.

Entry informationi

Entry nameiQ3T1L6_RAT
AccessioniPrimary (citable) accession number: Q3T1L6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.