Q3T1L5 (ALG6_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 46.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase EC=2.4.1.267 Alternative name(s): Asparagine-linked glycosylation protein 6 homolog Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 507 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man9GlcNAc(2)-PP-Dol By similarity. |
| Catalytic activity | Dolichyl beta-D-glucosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. |
| Pathway | |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the ALG6/ALG8 glucosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 507 | 507 | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase | PRO_0000284133 | |||||
Regions | |||||||||
| Transmembrane | 4 – 24 | 21 | Helical; Potential | ||||||
| Transmembrane | 115 – 135 | 21 | Helical; Potential | ||||||
| Transmembrane | 144 – 164 | 21 | Helical; Potential | ||||||
| Transmembrane | 173 – 193 | 21 | Helical; Potential | ||||||
| Transmembrane | 227 – 247 | 21 | Helical; Potential | ||||||
| Transmembrane | 298 – 318 | 21 | Helical; Potential | ||||||
| Transmembrane | 324 – 344 | 21 | Helical; Potential | ||||||
| Transmembrane | 362 – 382 | 21 | Helical; Potential | ||||||
| Transmembrane | 388 – 408 | 21 | Helical; Potential | ||||||
| Transmembrane | 438 – 458 | 21 | Helical; Potential | ||||||
| Transmembrane | 473 – 493 | 21 | Helical; Potential | ||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC101850 mRNA. Translation: AAI01851.1. |
| IPI | IPI00358784. |
| RefSeq | NP_001028881.1. NM_001033709.1. |
| UniGene | Rn.104225. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3T1L5. |
Protein family/group databases | |
| CAZy | GT57. Glycosyltransferase Family 57. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 362547. |
| KEGG | rno:362547. |
Organism-specific databases | |
| CTD | 29929. |
| RGD | 1308815. Alg6. |
Phylogenomic databases | |
| eggNOG | roNOG08658. |
| GeneTree | ENSGT00550000075073. |
| HOVERGEN | HBG024331. |
| OrthoDB | EOG4BP1BP. |
| PhylomeDB | Q3T1L5. |
Gene expression databases | |
| Genevestigator | Q3T1L5. |
Family and domain databases | |
| InterPro | IPR004856. Glyco_trans_ALG6/ALG8. [Graphical view] |
| KO | K03848. |
| PANTHER | PTHR12413. Alg6_Alg8. 1 hit. |
| Pfam | PF03155. Alg6_Alg8. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 680317. |
Entry information
| Entry name | ALG6_RAT | ||||||||
| Accession | Primary (citable) accession number: Q3T1L5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with