Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MOB kinase activator 1A

Gene

Mob1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79ZincBy similarity1
Metal bindingi84ZincBy similarity1
Metal bindingi161ZincBy similarity1
Metal bindingi166ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-2028269. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 1A
Alternative name(s):
Mob1 homolog 1B
Mps one binder kinase activator-like 1B
Gene namesi
Name:Mob1a
Synonyms:Mobk1b, Mobkl1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1307014. Mob1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002476052 – 216MOB kinase activator 1AAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei35PhosphothreonineBy similarity1
Modified residuei74Phosphothreonine; by STK3/MST2By similarity1
Modified residuei181PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T1J9.
PRIDEiQ3T1J9.

PTM databases

iPTMnetiQ3T1J9.
PhosphoSitePlusiQ3T1J9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000042657.
GenevisibleiQ3T1J9. RN.

Interactioni

Subunit structurei

Binds STK38 and STK38L. Interacts with LATS1 and LATS2 (By similarity). Forms a tripartite complex with STK38 and STK3/MST2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063824.

Structurei

3D structure databases

ProteinModelPortaliQ3T1J9.
SMRiQ3T1J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG0440. Eukaryota.
ENOG410XSUJ. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ3T1J9.
KOiK06685.
OMAiEFCTETS.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ3T1J9.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T1J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG
60 70 80 90 100
EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LGSKDR
Length:216
Mass (Da):25,080
Last modified:January 23, 2007 - v3
Checksum:i58043AECAD1F5987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101879 mRNA. Translation: AAI01880.1.
RefSeqiNP_001029063.1. NM_001033891.1.
UniGeneiRn.74475.

Genome annotation databases

EnsembliENSRNOT00000090987; ENSRNOP00000072053; ENSRNOG00000059474.
GeneIDi297387.
KEGGirno:297387.
UCSCiRGD:1307014. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101879 mRNA. Translation: AAI01880.1.
RefSeqiNP_001029063.1. NM_001033891.1.
UniGeneiRn.74475.

3D structure databases

ProteinModelPortaliQ3T1J9.
SMRiQ3T1J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063824.

PTM databases

iPTMnetiQ3T1J9.
PhosphoSitePlusiQ3T1J9.

Proteomic databases

PaxDbiQ3T1J9.
PRIDEiQ3T1J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090987; ENSRNOP00000072053; ENSRNOG00000059474.
GeneIDi297387.
KEGGirno:297387.
UCSCiRGD:1307014. rat.

Organism-specific databases

CTDi55233.
RGDi1307014. Mob1a.

Phylogenomic databases

eggNOGiKOG0440. Eukaryota.
ENOG410XSUJ. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ3T1J9.
KOiK06685.
OMAiEFCTETS.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ3T1J9.
TreeFamiTF300789.

Enzyme and pathway databases

ReactomeiR-RNO-2028269. Signaling by Hippo.

Miscellaneous databases

PROiQ3T1J9.

Gene expression databases

BgeeiENSRNOG00000042657.
GenevisibleiQ3T1J9. RN.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOB1A_RAT
AccessioniPrimary (citable) accession number: Q3T1J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.