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Q3T1J2

- MBOA2_RAT

UniProt

Q3T1J2 - MBOA2_RAT

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Protein
Membrane-bound O-acyltransferase domain-containing protein 2
Gene
Mboat2, Oact2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei341 – 3411 By similarity
Active sitei372 – 3721 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups Source: UniProtKB-KW

GO - Biological processi

  1. phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_199127. Acyl chain remodelling of PC.
REACT_199147. Acyl chain remodelling of PE.
UniPathwayiUPA00085.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound O-acyltransferase domain-containing protein 2 (EC:2.3.-.-)
Short name:
O-acyltransferase domain-containing protein 2
Gene namesi
Name:Mboat2
Synonyms:Oact2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1305798. Mboat2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed prediction
Add
BLAST
Transmembranei61 – 8121Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Reviewed prediction
Add
BLAST
Transmembranei288 – 30518Helical; Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST
Transmembranei415 – 43521Helical; Reviewed prediction
Add
BLAST
Transmembranei443 – 46321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Membrane-bound O-acyltransferase domain-containing protein 2
PRO_0000273022Add
BLAST

Proteomic databases

PaxDbiQ3T1J2.

Expressioni

Gene expression databases

GenevestigatoriQ3T1J2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009018.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5202.
HOGENOMiHOG000015994.
HOVERGENiHBG058823.
InParanoidiQ3T1J2.
KOiK13517.
OrthoDBiEOG73Z2SW.
PhylomeDBiQ3T1J2.
TreeFamiTF314906.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T1J2-1 [UniParc]FASTAAdd to Basket

« Hide

MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAV WFRTYLHSSK    50
TSSFIRHVVA TLLGLYLAFF CFGWYALHFL VQSGISYCIM IIAGVESMHQ 100
CCFVFALGYL SVCQITRVYI FDYGQYSADF SGPMMIITQK ITSLAYEIHD 150
GMFRKDEELT PSQRGLAVRR MPSLLEYVSY TCNFMGILAG PLCSYKDYIA 200
FIEGRASHMA QSGENGKEEQ HGKAEPSPNA AVTEKLLVCG LSLLFHLTIS 250
SMLPVEYNID EHFQATASWP TKATYLYVSL LAARPKYYFA WTLADAINNA 300
AGFGFRGYDK NGVARWDLIS NLRIQQIEMS TSFKMFLDNW NIQTALWLKR 350
VCYERATFSP TVQTFFLSAI WHGVYPGYYL TFLTGVLMTL AARAVRNNFR 400
HYFVEPPQLK LFYDIITWAA TQITISYTVV PFVLLSINPS FTFYRSWYYC 450
LHICSILVLL LLPVKKSPRK KNTEENAQPS WAKKFDEREN SLGQNSFSMM 500
NNVCNQNQDT GSRHSALTQ 519
Length:519
Mass (Da):59,001
Last modified:January 23, 2007 - v2
Checksum:iD5CAFBD16F7642B3
GO

Sequence cautioni

The sequence BC101889 differs from that shown. Reason: Frameshift at position 41.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03049793 Genomic DNA. No translation available.
AABR03054282 Genomic DNA. No translation available.
AABR03052483 Genomic DNA. No translation available.
AABR03050975 Genomic DNA. No translation available.
AABR03049616 Genomic DNA. No translation available.
BC101889 mRNA. No translation available.
RefSeqiNP_001101486.2. NM_001108016.2.
UniGeneiRn.35322.

Genome annotation databases

GeneIDi313997.
KEGGirno:313997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03049793 Genomic DNA. No translation available.
AABR03054282 Genomic DNA. No translation available.
AABR03052483 Genomic DNA. No translation available.
AABR03050975 Genomic DNA. No translation available.
AABR03049616 Genomic DNA. No translation available.
BC101889 mRNA. No translation available.
RefSeqi NP_001101486.2. NM_001108016.2.
UniGenei Rn.35322.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009018.

Proteomic databases

PaxDbi Q3T1J2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 313997.
KEGGi rno:313997.

Organism-specific databases

CTDi 129642.
RGDi 1305798. Mboat2.

Phylogenomic databases

eggNOGi COG5202.
HOGENOMi HOG000015994.
HOVERGENi HBG058823.
InParanoidi Q3T1J2.
KOi K13517.
OrthoDBi EOG73Z2SW.
PhylomeDBi Q3T1J2.
TreeFami TF314906.

Enzyme and pathway databases

UniPathwayi UPA00085 .
Reactomei REACT_199127. Acyl chain remodelling of PC.
REACT_199147. Acyl chain remodelling of PE.

Miscellaneous databases

NextBioi 667109.
PROi Q3T1J2.

Gene expression databases

Genevestigatori Q3T1J2.

Family and domain databases

InterProi IPR004299. MBOAT_fam.
[Graphical view ]
Pfami PF03062. MBOAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiMBOA2_RAT
AccessioniPrimary (citable) accession number: Q3T1J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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