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Q3T1J2 (MBOA2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-bound O-acyltransferase domain-containing protein 2

Short name=O-acyltransferase domain-containing protein 2
EC=2.3.-.-
Gene names
Name:Mboat2
Synonyms:Oact2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle By similarity.

Pathway

Lipid metabolism; phospholipid metabolism.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the membrane-bound acyltransferase family.

Sequence caution

The sequence BC101889 differs from that shown. Reason: Frameshift at position 41.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Membrane-bound O-acyltransferase domain-containing protein 2
PRO_0000273022

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane288 – 30518Helical; Potential
Transmembrane365 – 38521Helical; Potential
Transmembrane415 – 43521Helical; Potential
Transmembrane443 – 46321Helical; Potential

Sites

Active site3411 By similarity
Active site3721 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3T1J2 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: D5CAFBD16F7642B3

FASTA51959,001
        10         20         30         40         50         60 
MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAV WFRTYLHSSK TSSFIRHVVA 

        70         80         90        100        110        120 
TLLGLYLAFF CFGWYALHFL VQSGISYCIM IIAGVESMHQ CCFVFALGYL SVCQITRVYI 

       130        140        150        160        170        180 
FDYGQYSADF SGPMMIITQK ITSLAYEIHD GMFRKDEELT PSQRGLAVRR MPSLLEYVSY 

       190        200        210        220        230        240 
TCNFMGILAG PLCSYKDYIA FIEGRASHMA QSGENGKEEQ HGKAEPSPNA AVTEKLLVCG 

       250        260        270        280        290        300 
LSLLFHLTIS SMLPVEYNID EHFQATASWP TKATYLYVSL LAARPKYYFA WTLADAINNA 

       310        320        330        340        350        360 
AGFGFRGYDK NGVARWDLIS NLRIQQIEMS TSFKMFLDNW NIQTALWLKR VCYERATFSP 

       370        380        390        400        410        420 
TVQTFFLSAI WHGVYPGYYL TFLTGVLMTL AARAVRNNFR HYFVEPPQLK LFYDIITWAA 

       430        440        450        460        470        480 
TQITISYTVV PFVLLSINPS FTFYRSWYYC LHICSILVLL LLPVKKSPRK KNTEENAQPS 

       490        500        510 
WAKKFDEREN SLGQNSFSMM NNVCNQNQDT GSRHSALTQ 

« Hide

References

[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR03049793 Genomic DNA. No translation available.
AABR03054282 Genomic DNA. No translation available.
AABR03052483 Genomic DNA. No translation available.
AABR03050975 Genomic DNA. No translation available.
AABR03049616 Genomic DNA. No translation available.
BC101889 mRNA. No translation available.
RefSeqNP_001101486.2. NM_001108016.2.
UniGeneRn.35322.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009018.

Proteomic databases

PaxDbQ3T1J2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID313997.
KEGGrno:313997.

Organism-specific databases

CTD129642.
RGD1305798. Mboat2.

Phylogenomic databases

eggNOGCOG5202.
HOGENOMHOG000015994.
HOVERGENHBG058823.
InParanoidQ3T1J2.
KOK13517.
OrthoDBEOG73Z2SW.
PhylomeDBQ3T1J2.
TreeFamTF314906.

Enzyme and pathway databases

UniPathwayUPA00085.

Gene expression databases

GenevestigatorQ3T1J2.

Family and domain databases

InterProIPR004299. MBOAT_fam.
[Graphical view]
PfamPF03062. MBOAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio667109.
PROQ3T1J2.

Entry information

Entry nameMBOA2_RAT
AccessionPrimary (citable) accession number: Q3T1J2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways