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Q3T1J2

- MBOA2_RAT

UniProt

Q3T1J2 - MBOA2_RAT

Protein

Membrane-bound O-acyltransferase domain-containing protein 2

Gene

Mboat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei341 – 3411By similarity
    Active sitei372 – 3721By similarity

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. phospholipid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_199127. Acyl chain remodelling of PC.
    REACT_199147. Acyl chain remodelling of PE.
    UniPathwayiUPA00085.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-bound O-acyltransferase domain-containing protein 2 (EC:2.3.-.-)
    Short name:
    O-acyltransferase domain-containing protein 2
    Gene namesi
    Name:Mboat2
    Synonyms:Oact2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1305798. Mboat2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Membrane-bound O-acyltransferase domain-containing protein 2PRO_0000273022Add
    BLAST

    Proteomic databases

    PaxDbiQ3T1J2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3T1J2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009018.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5202.
    HOGENOMiHOG000015994.
    HOVERGENiHBG058823.
    InParanoidiQ3T1J2.
    KOiK13517.
    OrthoDBiEOG73Z2SW.
    PhylomeDBiQ3T1J2.
    TreeFamiTF314906.

    Family and domain databases

    InterProiIPR004299. MBOAT_fam.
    [Graphical view]
    PfamiPF03062. MBOAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3T1J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAV WFRTYLHSSK    50
    TSSFIRHVVA TLLGLYLAFF CFGWYALHFL VQSGISYCIM IIAGVESMHQ 100
    CCFVFALGYL SVCQITRVYI FDYGQYSADF SGPMMIITQK ITSLAYEIHD 150
    GMFRKDEELT PSQRGLAVRR MPSLLEYVSY TCNFMGILAG PLCSYKDYIA 200
    FIEGRASHMA QSGENGKEEQ HGKAEPSPNA AVTEKLLVCG LSLLFHLTIS 250
    SMLPVEYNID EHFQATASWP TKATYLYVSL LAARPKYYFA WTLADAINNA 300
    AGFGFRGYDK NGVARWDLIS NLRIQQIEMS TSFKMFLDNW NIQTALWLKR 350
    VCYERATFSP TVQTFFLSAI WHGVYPGYYL TFLTGVLMTL AARAVRNNFR 400
    HYFVEPPQLK LFYDIITWAA TQITISYTVV PFVLLSINPS FTFYRSWYYC 450
    LHICSILVLL LLPVKKSPRK KNTEENAQPS WAKKFDEREN SLGQNSFSMM 500
    NNVCNQNQDT GSRHSALTQ 519
    Length:519
    Mass (Da):59,001
    Last modified:January 23, 2007 - v2
    Checksum:iD5CAFBD16F7642B3
    GO

    Sequence cautioni

    The sequence BC101889 differs from that shown. Reason: Frameshift at position 41.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03049793 Genomic DNA. No translation available.
    AABR03054282 Genomic DNA. No translation available.
    AABR03052483 Genomic DNA. No translation available.
    AABR03050975 Genomic DNA. No translation available.
    AABR03049616 Genomic DNA. No translation available.
    BC101889 mRNA. No translation available.
    RefSeqiNP_001101486.2. NM_001108016.2.
    UniGeneiRn.35322.

    Genome annotation databases

    GeneIDi313997.
    KEGGirno:313997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03049793 Genomic DNA. No translation available.
    AABR03054282 Genomic DNA. No translation available.
    AABR03052483 Genomic DNA. No translation available.
    AABR03050975 Genomic DNA. No translation available.
    AABR03049616 Genomic DNA. No translation available.
    BC101889 mRNA. No translation available.
    RefSeqi NP_001101486.2. NM_001108016.2.
    UniGenei Rn.35322.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009018.

    Proteomic databases

    PaxDbi Q3T1J2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 313997.
    KEGGi rno:313997.

    Organism-specific databases

    CTDi 129642.
    RGDi 1305798. Mboat2.

    Phylogenomic databases

    eggNOGi COG5202.
    HOGENOMi HOG000015994.
    HOVERGENi HBG058823.
    InParanoidi Q3T1J2.
    KOi K13517.
    OrthoDBi EOG73Z2SW.
    PhylomeDBi Q3T1J2.
    TreeFami TF314906.

    Enzyme and pathway databases

    UniPathwayi UPA00085 .
    Reactomei REACT_199127. Acyl chain remodelling of PC.
    REACT_199147. Acyl chain remodelling of PE.

    Miscellaneous databases

    NextBioi 667109.
    PROi Q3T1J2.

    Gene expression databases

    Genevestigatori Q3T1J2.

    Family and domain databases

    InterProi IPR004299. MBOAT_fam.
    [Graphical view ]
    Pfami PF03062. MBOAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiMBOA2_RAT
    AccessioniPrimary (citable) accession number: Q3T1J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3