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Protein

RNA polymerase II-associated protein 1

Gene

Rpap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated protein 1
Gene namesi
Name:Rpap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1590891 Rpap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848431 – 1400RNA polymerase II-associated protein 1Add BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3T1I9
PRIDEiQ3T1I9

PTM databases

iPTMnetiQ3T1I9
PhosphoSitePlusiQ3T1I9

Expressioni

Gene expression databases

BgeeiENSRNOG00000005483
GenevisibleiQ3T1I9 RN

Interactioni

Subunit structurei

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007299

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi834 – 1293Leu-richAdd BLAST460

Sequence similaritiesi

Belongs to the RPAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1894 Eukaryota
ENOG410XNVT LUCA
GeneTreeiENSGT00390000007594
HOGENOMiHOG000154180
HOVERGENiHBG057248
InParanoidiQ3T1I9
KOiK20826
OMAiQWVLVLE
OrthoDBiEOG091G06IW
PhylomeDBiQ3T1I9
TreeFamiTF324391

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR013929 RNA_pol_II_AP1_C
IPR013930 RNA_pol_II_AP1_N
PfamiView protein in Pfam
PF08620 RPAP1_C, 1 hit
PF08621 RPAP1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

Q3T1I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSRPKPGE SEVDLLRFQS QFLEAGAAPA VQLVKGSRRR GDAHPDQLPP
60 70 80 90 100
QDHRDVVMLD SLPDLPPALL PAPSKRARPS PGRPLPHDED PEERLNRHDE
110 120 130 140 150
HITAVLSKIV ERDTSSVTVT LPVPSGVAFP PVFHRSQERQ VKPAASSKRS
160 170 180 190 200
IFAQEIAARR VSDNRAPSAE QVVPSPDAPE GAVPCETPSS KDRGSQLPGR
210 220 230 240 250
SHSFHRPNLI TGKGLRSQAA VQEVQTIHEE NVARLQAMDP EEILKEQQQL
260 270 280 290 300
LAQLDPSLVA FLRAHNHTRE QTETKATKEQ NPERPSVPVS KEEPIMSTCT
310 320 330 340 350
GESGTRDKLE DKLEDKLQPR TPALKLPMTP NKEWLHMDTV ELEKLHWTQD
360 370 380 390 400
LPPLRRQQTQ ERMQARFSLQ GELLEPDVDL PTHLGLHHHG EEAERAGYSL
410 420 430 440 450
QELFHLTRSQ VSQQRALALH VLSHIVGRAQ AGEFGDRLVG SVLRLLLDAG
460 470 480 490 500
FLFLLRFSLD DRIDSVIAAA VRALRALLVA PGDEELLDST FSWYHGASVF
510 520 530 540 550
PMMPSHDDKE DEDEDEELTK EKVNRKTPEE GSRPPPDLAR HDVIKGLLAT
560 570 580 590 600
NLLPRFRYVL EVTCPGPSVV LDILAVLIRL ARHSLESAMR VLECPRLMET
610 620 630 640 650
IVREFLPTSW SPIGVGPAPS LYKVPCAAAM KLLRVLASAG RNIAARLLSS
660 670 680 690 700
FDVRSRLCRF IAEAPRDLAL PFEEAEILTT EAFRLWAVAA SYGQGGDLYR
710 720 730 740 750
ELYPVLMRAL QTLPPELSTH PLQPLSMQRM ASLLTLLTQL TLAASTQPEA
760 770 780 790 800
TSGSVESCVV AIPSSITWTH VSGLKPLVEP CLKQTLKFLR RPDVWNALGP
810 820 830 840 850
VPSACLLFLG AYYQTWSQQS GLCPEDWLQD MERFLDEFLL PLLSQPPLGR
860 870 880 890 900
MWDSLRDCSP LCNPLSCAST PEALPSLVSL GCAGGCPPLS VAGSASPFPF
910 920 930 940 950
LTALLSLINT LGQIHKGLCR QLAVVLTAPG LQNYFLQCVA PAPAPQLTPF
960 970 980 990 1000
SAWALRHEYH LQYLVLSLAQ KAATSQPEPA ASTALHHVMA LVLLSRLLPG
1010 1020 1030 1040 1050
SEFLAHELLL SCVFRLGFLP ENASGGPEAA DFSDGLSLGN SGDPHCRRGA
1060 1070 1080 1090 1100
LLVQACQDLP SIRSCYLAHC SPARASLLTS QALYRGELPR VSSLLLPVPK
1110 1120 1130 1140 1150
EPLLPTDWPF QPLIHLYHRA SDTPSGLPAA DTVGITMRVL QWVLVLESWR
1160 1170 1180 1190 1200
PEALWAVPPA ARLARLMCVY LVDSELFRET PIQRLVAALL ARLCQPQVLP
1210 1220 1230 1240 1250
NLKLDCPLPG LTSFPDLYAS FLDHFEAVSF GDHLFGALVL LPLQRRFSVT
1260 1270 1280 1290 1300
LRLALFGEHV GVLRALGLPL AQLPVPLECY TEPAEDSLAL LQLYFRALVT
1310 1320 1330 1340 1350
GALHARWCPV LYTVAVAHVN SFVFCQDPKS SDEVKAARRS MLQKVWLLAD
1360 1370 1380 1390 1400
KDLRQHLLHY KLPNSSLPEG FELYPQLPRL RQQYLQTLPT EVLQNGGFKT
Length:1,400
Mass (Da):154,759
Last modified:October 11, 2005 - v1
Checksum:i7E9A525448EBC6B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101894 mRNA No translation available.
RefSeqiNP_001029171.1, NM_001033999.2
XP_006234833.1, XM_006234771.3
XP_006234834.1, XM_006234772.3
XP_006234835.1, XM_006234773.3
XP_017447220.1, XM_017591731.1
XP_017447221.1, XM_017591732.1
UniGeneiRn.12520

Genome annotation databases

EnsembliENSRNOT00000007299; ENSRNOP00000007299; ENSRNOG00000005483
GeneIDi311338
KEGGirno:311338
UCSCiRGD:1590891 rat

Entry informationi

Entry nameiRPAP1_RAT
AccessioniPrimary (citable) accession number: Q3T1I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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