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Protein

RNA polymerase II-associated protein 1

Gene

Rpap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated protein 1
Gene namesi
Name:Rpap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1590891. Rpap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14001400RNA polymerase II-associated protein 1PRO_0000284843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3T1I9.
PRIDEiQ3T1I9.

PTM databases

iPTMnetiQ3T1I9.

Expressioni

Gene expression databases

GenevisibleiQ3T1I9. RN.

Interactioni

Subunit structurei

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007299.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi834 – 1293460Leu-richAdd
BLAST

Sequence similaritiesi

Belongs to the RPAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1894. Eukaryota.
ENOG410XNVT. LUCA.
GeneTreeiENSGT00390000007594.
HOGENOMiHOG000154180.
HOVERGENiHBG057248.
InParanoidiQ3T1I9.
OMAiQWVLVLE.
OrthoDBiEOG7WDN28.
PhylomeDBiQ3T1I9.
TreeFamiTF324391.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013929. RNA_pol_II_AP1_C.
IPR013930. RNA_pol_II_AP1_N.
[Graphical view]
PfamiPF08620. RPAP1_C. 1 hit.
PF08621. RPAP1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q3T1I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSRPKPGE SEVDLLRFQS QFLEAGAAPA VQLVKGSRRR GDAHPDQLPP
60 70 80 90 100
QDHRDVVMLD SLPDLPPALL PAPSKRARPS PGRPLPHDED PEERLNRHDE
110 120 130 140 150
HITAVLSKIV ERDTSSVTVT LPVPSGVAFP PVFHRSQERQ VKPAASSKRS
160 170 180 190 200
IFAQEIAARR VSDNRAPSAE QVVPSPDAPE GAVPCETPSS KDRGSQLPGR
210 220 230 240 250
SHSFHRPNLI TGKGLRSQAA VQEVQTIHEE NVARLQAMDP EEILKEQQQL
260 270 280 290 300
LAQLDPSLVA FLRAHNHTRE QTETKATKEQ NPERPSVPVS KEEPIMSTCT
310 320 330 340 350
GESGTRDKLE DKLEDKLQPR TPALKLPMTP NKEWLHMDTV ELEKLHWTQD
360 370 380 390 400
LPPLRRQQTQ ERMQARFSLQ GELLEPDVDL PTHLGLHHHG EEAERAGYSL
410 420 430 440 450
QELFHLTRSQ VSQQRALALH VLSHIVGRAQ AGEFGDRLVG SVLRLLLDAG
460 470 480 490 500
FLFLLRFSLD DRIDSVIAAA VRALRALLVA PGDEELLDST FSWYHGASVF
510 520 530 540 550
PMMPSHDDKE DEDEDEELTK EKVNRKTPEE GSRPPPDLAR HDVIKGLLAT
560 570 580 590 600
NLLPRFRYVL EVTCPGPSVV LDILAVLIRL ARHSLESAMR VLECPRLMET
610 620 630 640 650
IVREFLPTSW SPIGVGPAPS LYKVPCAAAM KLLRVLASAG RNIAARLLSS
660 670 680 690 700
FDVRSRLCRF IAEAPRDLAL PFEEAEILTT EAFRLWAVAA SYGQGGDLYR
710 720 730 740 750
ELYPVLMRAL QTLPPELSTH PLQPLSMQRM ASLLTLLTQL TLAASTQPEA
760 770 780 790 800
TSGSVESCVV AIPSSITWTH VSGLKPLVEP CLKQTLKFLR RPDVWNALGP
810 820 830 840 850
VPSACLLFLG AYYQTWSQQS GLCPEDWLQD MERFLDEFLL PLLSQPPLGR
860 870 880 890 900
MWDSLRDCSP LCNPLSCAST PEALPSLVSL GCAGGCPPLS VAGSASPFPF
910 920 930 940 950
LTALLSLINT LGQIHKGLCR QLAVVLTAPG LQNYFLQCVA PAPAPQLTPF
960 970 980 990 1000
SAWALRHEYH LQYLVLSLAQ KAATSQPEPA ASTALHHVMA LVLLSRLLPG
1010 1020 1030 1040 1050
SEFLAHELLL SCVFRLGFLP ENASGGPEAA DFSDGLSLGN SGDPHCRRGA
1060 1070 1080 1090 1100
LLVQACQDLP SIRSCYLAHC SPARASLLTS QALYRGELPR VSSLLLPVPK
1110 1120 1130 1140 1150
EPLLPTDWPF QPLIHLYHRA SDTPSGLPAA DTVGITMRVL QWVLVLESWR
1160 1170 1180 1190 1200
PEALWAVPPA ARLARLMCVY LVDSELFRET PIQRLVAALL ARLCQPQVLP
1210 1220 1230 1240 1250
NLKLDCPLPG LTSFPDLYAS FLDHFEAVSF GDHLFGALVL LPLQRRFSVT
1260 1270 1280 1290 1300
LRLALFGEHV GVLRALGLPL AQLPVPLECY TEPAEDSLAL LQLYFRALVT
1310 1320 1330 1340 1350
GALHARWCPV LYTVAVAHVN SFVFCQDPKS SDEVKAARRS MLQKVWLLAD
1360 1370 1380 1390 1400
KDLRQHLLHY KLPNSSLPEG FELYPQLPRL RQQYLQTLPT EVLQNGGFKT
Length:1,400
Mass (Da):154,759
Last modified:October 11, 2005 - v1
Checksum:i7E9A525448EBC6B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101894 mRNA. No translation available.
RefSeqiNP_001029171.1. NM_001033999.2.
XP_006234833.1. XM_006234771.2.
XP_006234834.1. XM_006234772.2.
XP_006234835.1. XM_006234773.2.
UniGeneiRn.12520.

Genome annotation databases

EnsembliENSRNOT00000007299; ENSRNOP00000007299; ENSRNOG00000005483.
GeneIDi311338.
KEGGirno:311338.
UCSCiRGD:1590891. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101894 mRNA. No translation available.
RefSeqiNP_001029171.1. NM_001033999.2.
XP_006234833.1. XM_006234771.2.
XP_006234834.1. XM_006234772.2.
XP_006234835.1. XM_006234773.2.
UniGeneiRn.12520.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007299.

PTM databases

iPTMnetiQ3T1I9.

Proteomic databases

PaxDbiQ3T1I9.
PRIDEiQ3T1I9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007299; ENSRNOP00000007299; ENSRNOG00000005483.
GeneIDi311338.
KEGGirno:311338.
UCSCiRGD:1590891. rat.

Organism-specific databases

CTDi26015.
RGDi1590891. Rpap1.

Phylogenomic databases

eggNOGiKOG1894. Eukaryota.
ENOG410XNVT. LUCA.
GeneTreeiENSGT00390000007594.
HOGENOMiHOG000154180.
HOVERGENiHBG057248.
InParanoidiQ3T1I9.
OMAiQWVLVLE.
OrthoDBiEOG7WDN28.
PhylomeDBiQ3T1I9.
TreeFamiTF324391.

Miscellaneous databases

PROiQ3T1I9.

Gene expression databases

GenevisibleiQ3T1I9. RN.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013929. RNA_pol_II_AP1_C.
IPR013930. RNA_pol_II_AP1_N.
[Graphical view]
PfamiPF08620. RPAP1_C. 1 hit.
PF08621. RPAP1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPAP1_RAT
AccessioniPrimary (citable) accession number: Q3T1I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.