Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase E3D

Gene

Ube3d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase E3D (EC:6.3.2.-)
Alternative name(s):
UbcH10-binding protein with a HECT-like domain
Ubiquitin-conjugating enzyme E2C-binding protein
Gene namesi
Name:Ube3d
Synonyms:H10bh, Ube2cbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1306773. Ube3d.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003111932 – 370E3 ubiquitin-protein ligase E3DAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Post-translational modificationi

Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme).By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ3T1H6.

PTM databases

PhosphoSitePlusiQ3T1H6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010802.
ExpressionAtlasiQ3T1H6. differential.
GenevisibleiQ3T1H6. RN.

Interactioni

Subunit structurei

Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014600.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 236Interaction with UBE2CBy similarityAdd BLAST23
Regioni332 – 368HECT-likeBy similarityAdd BLAST37

Domaini

The C-terminal half (AA 167-370) is able to bind cyclin-B and shows a self-ubiquitination activity (mono-, poly, or multi-ubiquitination) in a HECT-like sequence dependent manner.By similarity

Phylogenomic databases

eggNOGiKOG4784. Eukaryota.
ENOG4111HHQ. LUCA.
GeneTreeiENSGT00390000003986.
HOGENOMiHOG000154750.
HOVERGENiHBG056762.
InParanoidiQ3T1H6.
KOiK20803.
OMAiQECCTFY.
OrthoDBiEOG091G09U8.
PhylomeDBiQ3T1H6.
TreeFamiTF324684.

Family and domain databases

InterProiIPR019193. UBQ-conj_enz_E2-bd_prot.
[Graphical view]
PfamiPF09814. HECT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T1H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVEAETRV FLEVRRRLQS ALLILGEPDE GGMNLDISVT PTSLLMRSPD
60 70 80 90 100
GCTEIRLPAG VRLAPSSCGG LQYISGDGLH LRLRAQAESS PQPISGFNQS
110 120 130 140 150
LQAQECCSFY CQSCGEVTIK DRKLLRVLPL PSENWSALVG EWCCHPDPFA
160 170 180 190 200
NKPLHPREND CFVGDSFFLV NSRSDLEQEP KANTKVICKR CKVMLGETVS
210 220 230 240 250
SETTKFYMTE VIVQPSEGSF PNIPRSQFVQ SVIARCLVEL CTARSTFRFT
260 270 280 290 300
IQGQDGKVYI LLWVLNSDSL VMEPLSSSGC IRKFPLLEDS LEADSGSAWN
310 320 330 340 350
AIKVLYQPCI KSRNKELASS WEGDISVHPL TLPSTTCLEL LLILSRNNAS
360 370
LPLSLRQMNS FQLWCSHCKT
Length:370
Mass (Da):41,056
Last modified:October 11, 2005 - v1
Checksum:iFF97D69330D51B83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101916 mRNA. Translation: AAI01917.1.
RefSeqiNP_001034699.1. NM_001039610.1.
UniGeneiRn.205206.

Genome annotation databases

EnsembliENSRNOT00000014600; ENSRNOP00000014600; ENSRNOG00000010802.
GeneIDi315863.
KEGGirno:315863.
UCSCiRGD:1306773. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101916 mRNA. Translation: AAI01917.1.
RefSeqiNP_001034699.1. NM_001039610.1.
UniGeneiRn.205206.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014600.

PTM databases

PhosphoSitePlusiQ3T1H6.

Proteomic databases

PaxDbiQ3T1H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014600; ENSRNOP00000014600; ENSRNOG00000010802.
GeneIDi315863.
KEGGirno:315863.
UCSCiRGD:1306773. rat.

Organism-specific databases

CTDi90025.
RGDi1306773. Ube3d.

Phylogenomic databases

eggNOGiKOG4784. Eukaryota.
ENOG4111HHQ. LUCA.
GeneTreeiENSGT00390000003986.
HOGENOMiHOG000154750.
HOVERGENiHBG056762.
InParanoidiQ3T1H6.
KOiK20803.
OMAiQECCTFY.
OrthoDBiEOG091G09U8.
PhylomeDBiQ3T1H6.
TreeFamiTF324684.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ3T1H6.

Gene expression databases

BgeeiENSRNOG00000010802.
ExpressionAtlasiQ3T1H6. differential.
GenevisibleiQ3T1H6. RN.

Family and domain databases

InterProiIPR019193. UBQ-conj_enz_E2-bd_prot.
[Graphical view]
PfamiPF09814. HECT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBE3D_RAT
AccessioniPrimary (citable) accession number: Q3T1H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.