Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

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Reviewed, UniProtKB/Swiss-Prot Q3T189 (DHSB_BOVIN)

Last modified November 3, 2009. Version 40. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
    EC=1.3.5.1
Alternative name(s):
    Iron-sulfur subunit of complex II
      Short name=IP

Gene names

Name:

SDHB

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	Binds 1 2Fe-2S cluster By similarity. Binds 1 3Fe-4S cluster By similarity. Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

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Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 28

Mitochondrion By similarity

Chain

29 – 280

252

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

PRO_0000247594

Regions

Domain

40 – 133

2Fe-2S ferredoxin-type

Domain

176 – 206

4Fe-4S ferredoxin-type

Sites

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

101

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

113

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

186

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

189

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

192

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

196

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

243

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

249

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

253

Iron-sulfur 2 (4Fe-4S) By similarity

Binding site

201

Ubiquinone; shared with DHSD By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q3T189-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: BE51FF2193F8B6C5
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FASTA

280

31,518

        10         20         30         40         50         60 
MAAVVALSLR RRFPAAALGG ARLQACRGAQ TAAAAAPRIK KFAIYRWDPD KTGDKPHMQT 

        70         80         90        100        110        120 
YEIDLNNCGP MVLDALIKIK NEIDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN 

       130        140        150        160        170        180 
LSKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQGGKEQY LQSIEDREKL 

       190        200        210        220        230        240 
DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL 

       250        260        270        280 
YRCHTIMNCT QTCPKGLNPG KAIAEIKKMM ATYKEKQASA

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References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

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Cross-references

Sequence databases
	BC102067 mRNA. Translation: AAI02068.1.
IPI	IPI00693011.
RefSeq	NP_001035573.1.
UniGene	Bt.13128
3D structure databases
SMR	Q3T189. Positions 37-275.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3T189.
Genome annotation databases
Ensembl	ENSBTAT00000010949; ENSBTAP00000010949; ENSBTAG00000008314; Bos taurus. [Genome view]
GeneID	286840.
KEGG	bta:286840.
Organism-specific databases
CTD	286840.
Phylogenomic databases
HOVERGEN	Q3T189.
OMA	LIVDMEP.
Enzyme and pathway databases
BRENDA	1.3.5.1. 251.
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. b-grasp_ferredoxin-like. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR004489. Succ_DH/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMs	TIGR00384. dhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

DHSB_BOVIN

Accession

Primary (citable) accession number: Q3T189

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 11, 2005
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents