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Q3T189 (SDHB_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=IP
Gene names
Name:SDHB
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + ubiquinone = fumarate + ubiquinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion By similarity
Chain29 – 280252Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
PRO_0000247594

Regions

Domain40 – 133942Fe-2S ferredoxin-type
Domain176 – 206314Fe-4S ferredoxin-type

Sites

Metal binding931Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding981Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1011Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1131Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1861Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1891Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1921Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2431Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2491Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2531Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2011Ubiquinone; shared with DHSD By similarity

Amino acid modifications

Modified residue511N6-acetyllysine By similarity
Modified residue551N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3T189 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: BE51FF2193F8B6C5

FASTA28031,518
        10         20         30         40         50         60 
MAAVVALSLR RRFPAAALGG ARLQACRGAQ TAAAAAPRIK KFAIYRWDPD KTGDKPHMQT 

        70         80         90        100        110        120 
YEIDLNNCGP MVLDALIKIK NEIDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN 

       130        140        150        160        170        180 
LSKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQGGKEQY LQSIEDREKL 

       190        200        210        220        230        240 
DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL 

       250        260        270        280 
YRCHTIMNCT QTCPKGLNPG KAIAEIKKMM ATYKEKQASA 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102067 mRNA. Translation: AAI02068.1.
RefSeqNP_001035573.1. NM_001040483.1.
UniGeneBt.13128.

3D structure databases

ProteinModelPortalQ3T189.
SMRQ3T189. Positions 37-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3T189. 2 interactions.

Proteomic databases

PaxDbQ3T189.
PRIDEQ3T189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000010949; ENSBTAP00000010949; ENSBTAG00000008314.
GeneID286840.
KEGGbta:286840.

Organism-specific databases

CTD6390.

Phylogenomic databases

eggNOGCOG0479.
GeneTreeENSGT00390000013558.
HOGENOMHOG000160590.
HOVERGENHBG005483.
InParanoidQ3T189.
KOK00235.
OMADSHERML.
OrthoDBEOG7H4DTN.
TreeFamTF300754.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Gene expression databases

ArrayExpressQ3T189.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806491.

Entry information

Entry nameSDHB_BOVIN
AccessionPrimary (citable) accession number: Q3T189
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 11, 2005
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways