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Protein

Leukotriene B4 receptor 1

Gene

LTB4R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-391906. Leukotriene receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:LTB4R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence analysisAdd
BLAST
Transmembranei20 – 4223Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 5412CytoplasmicSequence analysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9116ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini114 – 13825CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 17920ExtracellularSequence analysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini201 – 22222CytoplasmicSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini244 – 26926ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 34959CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Leukotriene B4 receptor 1PRO_0000245315Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3T181.
PRIDEiQ3T181.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036335.

Structurei

3D structure databases

ProteinModelPortaliQ3T181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ3T181.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG738056.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTSPAAPS SSGVSFISLL VIIVLSVALA VGLPGNSFVV WSILAKLRKR
60 70 80 90 100
SVTALMVLHL ALADLAVLLT APFFLYSVAQ GTWTFGLSSC RLFHYVCGVS
110 120 130 140 150
MYASVLLIMT MSLDRSLAVA LPFVSQKLRT KAVAWRVLAG IWVMSVLLAT
160 170 180 190 200
PVLLYRTVHL GLNNRSLTCF LKYPSERHRA FHLFFEVITG FLLPFLVVVA
210 220 230 240 250
SYCDIGRRLR ARRFRRSRRT GRLVALIILA FAAFWLPYHV VNLAEGFRAA
260 270 280 290 300
AGKALGSGPV GRRLLLARHV LITLAFLSSS VNPLLYACAG GGLLRSAGVG
310 320 330 340
FIAKLLEGTG SETSSSRRKG TLAQTLRGTP ASPEPDPAES LTASTNPLE
Length:349
Mass (Da):37,689
Last modified:October 11, 2005 - v1
Checksum:iF7B6B97DE6518191
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102075 mRNA. Translation: AAI02076.1.
RefSeqiNP_001029910.1. NM_001034738.1.
UniGeneiBt.16889.

Genome annotation databases

EnsembliENSBTAT00000036478; ENSBTAP00000036335; ENSBTAG00000010238.
GeneIDi613482.
KEGGibta:613482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102075 mRNA. Translation: AAI02076.1.
RefSeqiNP_001029910.1. NM_001034738.1.
UniGeneiBt.16889.

3D structure databases

ProteinModelPortaliQ3T181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036335.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ3T181.
PRIDEiQ3T181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000036478; ENSBTAP00000036335; ENSBTAG00000010238.
GeneIDi613482.
KEGGibta:613482.

Organism-specific databases

CTDi1241.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ3T181.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG738056.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-BTA-391906. Leukotriene receptors.
R-BTA-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi20898599.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiLT4R1_BOVIN
AccessioniPrimary (citable) accession number: Q3T181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.