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Protein

Leukotriene B4 receptor 1

Gene

LTB4R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-391906 Leukotriene receptors
R-BTA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:LTB4R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:31069 LTB4R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 42Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini43 – 54CytoplasmicSequence analysisAdd BLAST12
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 91ExtracellularSequence analysisAdd BLAST16
Transmembranei92 – 113Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini114 – 138CytoplasmicSequence analysisAdd BLAST25
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 179ExtracellularSequence analysisAdd BLAST20
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 222CytoplasmicSequence analysisAdd BLAST22
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 269ExtracellularSequence analysisAdd BLAST26
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 349CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453151 – 349Leukotriene B4 receptor 1Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3T181
PRIDEiQ3T181

Expressioni

Gene expression databases

BgeeiENSBTAG00000010238

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036335

Structurei

3D structure databases

ProteinModelPortaliQ3T181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000008594
HOVERGENiHBG104134
InParanoidiQ3T181
KOiK04296
OMAiYHVVNLA
OrthoDBiEOG091G0FBQ
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003981 Leukotriene_B4_rcpt
IPR003983 Leukotriene_B4_typ-1_rcpt
PANTHERiPTHR24230:SF51 PTHR24230:SF51, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01477 LTB1RECEPTOR
PR01476 LTBRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTSPAAPS SSGVSFISLL VIIVLSVALA VGLPGNSFVV WSILAKLRKR
60 70 80 90 100
SVTALMVLHL ALADLAVLLT APFFLYSVAQ GTWTFGLSSC RLFHYVCGVS
110 120 130 140 150
MYASVLLIMT MSLDRSLAVA LPFVSQKLRT KAVAWRVLAG IWVMSVLLAT
160 170 180 190 200
PVLLYRTVHL GLNNRSLTCF LKYPSERHRA FHLFFEVITG FLLPFLVVVA
210 220 230 240 250
SYCDIGRRLR ARRFRRSRRT GRLVALIILA FAAFWLPYHV VNLAEGFRAA
260 270 280 290 300
AGKALGSGPV GRRLLLARHV LITLAFLSSS VNPLLYACAG GGLLRSAGVG
310 320 330 340
FIAKLLEGTG SETSSSRRKG TLAQTLRGTP ASPEPDPAES LTASTNPLE
Length:349
Mass (Da):37,689
Last modified:October 11, 2005 - v1
Checksum:iF7B6B97DE6518191
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102075 mRNA Translation: AAI02076.1
RefSeqiNP_001029910.1, NM_001034738.1
UniGeneiBt.16889

Genome annotation databases

EnsembliENSBTAT00000036478; ENSBTAP00000036335; ENSBTAG00000010238
GeneIDi613482
KEGGibta:613482

Similar proteinsi

Entry informationi

Entry nameiLT4R1_BOVIN
AccessioniPrimary (citable) accession number: Q3T181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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