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Protein

Leukotriene B4 receptor 1

Gene

LTB4R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-391906. Leukotriene receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:LTB4R
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 42Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini43 – 54CytoplasmicSequence analysisAdd BLAST12
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 91ExtracellularSequence analysisAdd BLAST16
Transmembranei92 – 113Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini114 – 138CytoplasmicSequence analysisAdd BLAST25
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 179ExtracellularSequence analysisAdd BLAST20
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 222CytoplasmicSequence analysisAdd BLAST22
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 269ExtracellularSequence analysisAdd BLAST26
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 349CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453151 – 349Leukotriene B4 receptor 1Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ3T181.
PRIDEiQ3T181.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010238.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036335.

Structurei

3D structure databases

ProteinModelPortaliQ3T181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ3T181.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG091G0FBQ.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTSPAAPS SSGVSFISLL VIIVLSVALA VGLPGNSFVV WSILAKLRKR
60 70 80 90 100
SVTALMVLHL ALADLAVLLT APFFLYSVAQ GTWTFGLSSC RLFHYVCGVS
110 120 130 140 150
MYASVLLIMT MSLDRSLAVA LPFVSQKLRT KAVAWRVLAG IWVMSVLLAT
160 170 180 190 200
PVLLYRTVHL GLNNRSLTCF LKYPSERHRA FHLFFEVITG FLLPFLVVVA
210 220 230 240 250
SYCDIGRRLR ARRFRRSRRT GRLVALIILA FAAFWLPYHV VNLAEGFRAA
260 270 280 290 300
AGKALGSGPV GRRLLLARHV LITLAFLSSS VNPLLYACAG GGLLRSAGVG
310 320 330 340
FIAKLLEGTG SETSSSRRKG TLAQTLRGTP ASPEPDPAES LTASTNPLE
Length:349
Mass (Da):37,689
Last modified:October 11, 2005 - v1
Checksum:iF7B6B97DE6518191
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102075 mRNA. Translation: AAI02076.1.
RefSeqiNP_001029910.1. NM_001034738.1.
UniGeneiBt.16889.

Genome annotation databases

EnsembliENSBTAT00000036478; ENSBTAP00000036335; ENSBTAG00000010238.
GeneIDi613482.
KEGGibta:613482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102075 mRNA. Translation: AAI02076.1.
RefSeqiNP_001029910.1. NM_001034738.1.
UniGeneiBt.16889.

3D structure databases

ProteinModelPortaliQ3T181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000036335.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ3T181.
PRIDEiQ3T181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000036478; ENSBTAP00000036335; ENSBTAG00000010238.
GeneIDi613482.
KEGGibta:613482.

Organism-specific databases

CTDi1241.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ3T181.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG091G0FBQ.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-BTA-391906. Leukotriene receptors.
R-BTA-416476. G alpha (q) signalling events.

Gene expression databases

BgeeiENSBTAG00000010238.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLT4R1_BOVIN
AccessioniPrimary (citable) accession number: Q3T181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.