HSPB1

Functionⁱ

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
protein binding involved in protein folding Source: UniProtKB
protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterograde axonal protein transport Source: UniProtKB
chaperone-mediated protein folding Source: UniProtKB
regulation of protein phosphorylation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Stress response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock protein beta-1 Short name: HspB1 Alternative name(s): Heat shock 27 kDa protein Short name: HSP 27
Gene namesⁱ	Name:HSPB1 Synonyms:HSP27
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000125924	1 – 201	Heat shock protein beta-1Add BLAST		201

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	15	Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity	1
Modified residueⁱ	27	PhosphoserineBy similarity	1
Modified residueⁱ	74	Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity	1
Modified residueⁱ	78	Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity	1
Modified residueⁱ	79	PhosphoserineBy similarity	1
Modified residueⁱ	82	PhosphoserineBy similarity	1
Modified residueⁱ	94	PhosphoserineBy similarity	1
Modified residueⁱ	119	N6-acetyllysineBy similarity	1
Modified residueⁱ	170	PhosphothreonineBy similarity	1
Modified residueⁱ	172	PhosphoserineBy similarity	1
Modified residueⁱ	195	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement.By similarity

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q3T149
PeptideAtlas More...PeptideAtlasⁱ	Q3T149
PRIDEⁱ	Q3T149

PTM databases

iPTMnetⁱ	Q3T149

iPTMnetⁱ

Q3T149

Interactionⁱ

Subunit structureⁱ

Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin. Interacts with TGFB1I1. Interacts with CRYAB. Interacts with HSPB8. Interacts with HSPBAP1.By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
protein binding involved in protein folding Source: UniProtKB
protein homodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000015883

STRINGⁱ

9913.ENSBTAP00000015883

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3T149
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	72 – 180	sHSPPROSITE-ProRule annotationAdd BLAST		109

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	68 – 201	Interaction with TGFB1I1By similarityAdd BLAST		134

Sequence similaritiesⁱ

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
HOGENOMⁱ	HOG000233955
HOVERGENⁱ	HBG054766
InParanoidⁱ	Q3T149

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06475 ACD_HspB1_like, 1 hit
Gene3Dⁱ	2.60.40.7901 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3T149-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAERRVPFSL LRGPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS 
        60         70         80         90        100
GWPGYVRALP AAAIEGPAYN RALSRQLSSG VSEIQQTADR WRVSLDVNHF 
       110        120        130        140        150
APEELTVKTK DGVVEITGKH EERQDEHGYI SRCFTRKYTL PPGVDPTLVS 
       160        170        180        190        200
SSLSPEGTLT VEAPLPKSAT QSAEITIPVT FQARAQLGGP EAGKSEQPEN 

K

Length:201

Mass (Da):22,393

Last modified:October 11, 2005 - v1

Checksum:ⁱ9CEAFF050B7FAD24

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC102129 mRNA Translation: AAI02130.1
NCBI Reference Sequences More...RefSeqⁱ	XP_005225172.1, XM_005225115.1
UniGeneⁱ	Bt.4415

Genome annotation databases

GeneIDⁱ	516099

GeneIDⁱ

516099

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3T149	E9RHW1 A0A097PIG9 A0A1C9EIV9	Bos taurus (Bovine) Bubalus bubalis (Domestic water buffalo) Bos indicus (Zebu)	201	UniRef100_Q3T149	Cluster: Heat shock protein beta-1	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3T149	Q5S1U1 A0A2C9F366 A0A1B3B5W3 UPI0003EE32E7 M3YX29 UPI0002C55801 G9K4X9 A0A097HUC9 E1BEL7 UPI00045E09C8 +29	Sus scrofa (Pig) Sus scrofa domesticus (domestic pig) Leptonychotes weddellii (Weddell seal) Mustela putorius furo (European domestic ferret) (Mustela furo) Odobenus rosmarus divergens (Pacific walrus) Canis lupus familiaris (Dog) (Canis familiaris) Bos taurus (Bovine) Orycteropus afer afer Bos mutus (wild yak) Bos indicus (Zebu) And more	207	UniRef90_Q5S1U1	Cluster: Heat shock protein beta-1	40

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q3T149	Q5S1U1 A0A2C9F366 A0A1B3B5W3 M3YX29 UPI0003EE32E7 UPI0002C55801 A0A097HUC9 G9K4X9 UPI00045E09C8 E1BEL7 +31	Sus scrofa (Pig) Sus scrofa domesticus (domestic pig) Mustela putorius furo (European domestic ferret) (Mustela furo) Leptonychotes weddellii (Weddell seal) Odobenus rosmarus divergens (Pacific walrus) Canis lupus familiaris (Dog) (Canis familiaris) Orycteropus afer afer Bos taurus (Bovine) Bos mutus (wild yak) Lipotes vexillifer (Yangtze river dolphin) And more	207	UniRef50_Q5S1U1	Cluster: Heat shock protein beta-1	42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC102129 mRNA Translation: AAI02130.1
NCBI Reference Sequences More...RefSeqⁱ	XP_005225172.1, XM_005225115.1
UniGeneⁱ	Bt.4415

3D structure databases

ProteinModelPortalⁱ	Q3T149
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000015883

STRINGⁱ

9913.ENSBTAP00000015883

PTM databases

iPTMnetⁱ	Q3T149

iPTMnetⁱ

Q3T149

Proteomic databases

PaxDbⁱ	Q3T149
PeptideAtlas More...PeptideAtlasⁱ	Q3T149
PRIDEⁱ	Q3T149

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	516099

GeneIDⁱ

516099

Organism-specific databases

CTDⁱ	3315

CTDⁱ

3315

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
HOGENOMⁱ	HOG000233955
HOVERGENⁱ	HBG054766
InParanoidⁱ	Q3T149

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06475 ACD_HspB1_like, 1 hit
Gene3Dⁱ	2.60.40.7901 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSPB1_BOVIN
Accessionⁱ	Q3T149Primary (citable) accession number: Q3T149
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	October 11, 2005
	Last modified:	February 28, 2018
	This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3T149 (HSPB1_BOVIN)

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Heat shock protein beta-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ