UniProtKB - Q3T149 (HSPB1_BOVIN)
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Protein
Heat shock protein beta-1
Gene
HSPB1
Organism
Bos taurus (Bovine)
Status
Functioni
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein binding involved in protein folding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- anterograde axonal protein transport Source: UniProtKB
- chaperone-mediated protein folding Source: UniProtKB
- regulation of protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein beta-1Short name: HspB1 Alternative name(s): Heat shock 27 kDa protein Short name: HSP 27 |
Gene namesi | Name:HSPB1 Synonyms:HSP27 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125924 | 1 – 201 | Heat shock protein beta-1Add BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 15 | Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 74 | Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity | 1 | |
Modified residuei | 78 | Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity | 1 | |
Modified residuei | 79 | PhosphoserineBy similarity | 1 | |
Modified residuei | 82 | PhosphoserineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineBy similarity | 1 | |
Modified residuei | 119 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 170 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 195 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement.By similarity
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q3T149 |
PeptideAtlasi | Q3T149 |
PRIDEi | Q3T149 |
PTM databases
iPTMneti | Q3T149 |
Interactioni
Subunit structurei
Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin. Interacts with TGFB1I1. Interacts with CRYAB. Interacts with HSPB8. Interacts with HSPBAP1.By similarity
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein binding involved in protein folding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000015883 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 180 | sHSPPROSITE-ProRule annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 201 | Interaction with TGFB1I1By similarityAdd BLAST | 134 |
Sequence similaritiesi
Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3591 Eukaryota ENOG410YERS LUCA |
HOGENOMi | HOG000233955 |
HOVERGENi | HBG054766 |
InParanoidi | Q3T149 |
Family and domain databases
CDDi | cd06475 ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.7901 hit |
InterProi | View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone |
PANTHERi | PTHR11527 PTHR11527, 1 hit |
Pfami | View protein in Pfam PF00011 HSP20, 1 hit |
PRINTSi | PR00299 ACRYSTALLIN |
SUPFAMi | SSF49764 SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031 SHSP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3T149-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAERRVPFSL LRGPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS
60 70 80 90 100
GWPGYVRALP AAAIEGPAYN RALSRQLSSG VSEIQQTADR WRVSLDVNHF
110 120 130 140 150
APEELTVKTK DGVVEITGKH EERQDEHGYI SRCFTRKYTL PPGVDPTLVS
160 170 180 190 200
SSLSPEGTLT VEAPLPKSAT QSAEITIPVT FQARAQLGGP EAGKSEQPEN
K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102129 mRNA Translation: AAI02130.1 |
RefSeqi | XP_005225172.1, XM_005225115.1 |
UniGenei | Bt.4415 |
Genome annotation databases
GeneIDi | 516099 |
Similar proteinsi
Entry informationi
Entry namei | HSPB1_BOVIN | |
Accessioni | Q3T149Primary (citable) accession number: Q3T149 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 28, 2018 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |