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UniProtKB - Q3T149 (HSPB1_BOVIN)

UniProt

Q3T149 - HSPB1_BOVIN

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Protein

Heat shock protein beta-1

Gene

HSPB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in stress resistance and actin organization.By similarity

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-1
Short name:
HspB1
Alternative name(s):
Heat shock 27 kDa protein
Short name:
HSP 27
Gene namesi
Name:HSPB1
Synonyms:HSP27
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Cytoplasm › cytoskeleton › spindle By similarity

    • Note: Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Heat shock protein beta-1PRO_0000125924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei74 – 741Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity
Modified residuei78 – 781Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei119 – 1191N6-acetyllysineBy similarity
Modified residuei170 – 1701PhosphothreonineBy similarity
Modified residuei172 – 1721PhosphoserineBy similarity
Modified residuei195 – 1951PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress leads to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T149.
PeptideAtlasiQ3T149.
PRIDEiQ3T149.

PTM databases

iPTMnetiQ3T149.

Interactioni

Subunit structurei

Associates with alpha- and beta-tubulin, microtubules and CRYAB. Interacts with HSPB8, HSPBAP1 and TGFB1I1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015883.

Structurei

3D structure databases

ProteinModelPortaliQ3T149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 201134Interaction with TGFB1I1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ3T149.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERRVPFSL LRGPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS 
        60         70         80         90        100
GWPGYVRALP AAAIEGPAYN RALSRQLSSG VSEIQQTADR WRVSLDVNHF 
       110        120        130        140        150
APEELTVKTK DGVVEITGKH EERQDEHGYI SRCFTRKYTL PPGVDPTLVS 
       160        170        180        190        200
SSLSPEGTLT VEAPLPKSAT QSAEITIPVT FQARAQLGGP EAGKSEQPEN 

K
Length:201
Mass (Da):22,393
Last modified:October 11, 2005 - v1
Checksum:i9CEAFF050B7FAD24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102129 mRNA. Translation: AAI02130.1.
RefSeqiXP_005225172.1. XM_005225115.1.
UniGeneiBt.4415.

Genome annotation databases

GeneIDi516099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102129 mRNA. Translation: AAI02130.1.
RefSeqiXP_005225172.1. XM_005225115.1.
UniGeneiBt.4415.

3D structure databases

ProteinModelPortaliQ3T149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015883.

PTM databases

iPTMnetiQ3T149.

Proteomic databases

PaxDbiQ3T149.
PeptideAtlasiQ3T149.
PRIDEiQ3T149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi516099.

Organism-specific databases

CTDi3315.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ3T149.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB1_BOVIN
AccessioniPrimary (citable) accession number: Q3T149
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.