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Q3T133

- TMED9_BOVIN

UniProt

Q3T133 - TMED9_BOVIN

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Protein

Transmembrane emp24 domain-containing protein 9

Gene
TMED9
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 By similarity.

GO - Biological processi

  1. COPI coating of Golgi vesicle Source: UniProtKB
  2. Golgi organization Source: UniProtKB
  3. positive regulation of organelle organization Source: UniProtKB
  4. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 9
Alternative name(s):
p24 family protein alpha-2
Short name:
p24alpha2
Gene namesi
Name:TMED9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 201164Lumenal Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Reviewed predictionAdd
BLAST
Topological domaini223 – 23513Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. Golgi membrane Source: GOC
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 By similarityAdd
BLAST
Chaini38 – 235198Transmembrane emp24 domain-containing protein 9PRO_0000042789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Modified residuei160 – 1601N6-acetyllysine By similarity

Post-translational modificationi

N-linked glycosylated containing high mannose By similarity.

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ3T133.
PRIDEiQ3T133.

Interactioni

Subunit structurei

Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with STX17; the interaction is direct By similarity.

Protein-protein interaction databases

IntActiQ3T133. 4 interactions.
STRINGi9913.ENSBTAP00000001830.

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi231 – 2344

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J73X-ray1.44B229-235[»]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 14599GOLDAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni121 – 16040Required for interaction with STX17 By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili154 – 18431 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi228 – 2358COPI vesicle coat-binding Reviewed prediction
Motifi228 – 2292COPII vesicle coat-binding Reviewed prediction

Sequence similaritiesi

Belongs to the EMP24/GP25L family.
Contains 1 GOLD domain.

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323830.
GeneTreeiENSGT00430000030848.
HOGENOMiHOG000160228.
HOVERGENiHBG105357.
InParanoidiQ3T133.
OMAiVLWWSIV.
OrthoDBiEOG74BJT2.
TreeFamiTF314123.

Family and domain databases

InterProiIPR009038. GOLD.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T133-1 [UniParc]FASTAAdd to Basket

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MAAERSLWVV GLCPGSRLGR VVRVLLLLLW FAARGGALYF HIGETEKKCF    50
IEEIPDETMV IGNYRTQLYD KQREEYQPAT PGLGMFVEVK DPEDKVILAR 100
QYGSEGRFTF TSHTPGEHQI CLHSNSTKFS LFAGGMLRVH LDIQVGEHAN 150
DYAEIAAKDK LSELQLRVRQ LVEQVEQIQK EQNYQRWREE RFRQTSESTN 200
QRVLWWSILQ TLILVAIGVW QMRHLKSFFE AKKLV 235
Length:235
Mass (Da):27,298
Last modified:October 11, 2005 - v1
Checksum:i3F38C286A2021C16
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101F → I in AAX09080. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021063 mRNA. Translation: AAX09080.1.
BC102145 mRNA. Translation: AAI02146.1.
RefSeqiNP_001029984.1. NM_001034812.2.
UniGeneiBt.8094.

Genome annotation databases

EnsembliENSBTAT00000001830; ENSBTAP00000001830; ENSBTAG00000001394.
GeneIDi618580.
KEGGibta:618580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021063 mRNA. Translation: AAX09080.1 .
BC102145 mRNA. Translation: AAI02146.1 .
RefSeqi NP_001029984.1. NM_001034812.2.
UniGenei Bt.8094.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4J73 X-ray 1.44 B 229-235 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3T133. 4 interactions.
STRINGi 9913.ENSBTAP00000001830.

Proteomic databases

PaxDbi Q3T133.
PRIDEi Q3T133.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001830 ; ENSBTAP00000001830 ; ENSBTAG00000001394 .
GeneIDi 618580.
KEGGi bta:618580.

Organism-specific databases

CTDi 54732.

Phylogenomic databases

eggNOGi NOG323830.
GeneTreei ENSGT00430000030848.
HOGENOMi HOG000160228.
HOVERGENi HBG105357.
InParanoidi Q3T133.
OMAi VLWWSIV.
OrthoDBi EOG74BJT2.
TreeFami TF314123.

Miscellaneous databases

NextBioi 20901254.

Family and domain databases

InterProi IPR009038. GOLD.
IPR015720. TMP21-related.
[Graphical view ]
PANTHERi PTHR22811. PTHR22811. 1 hit.
Pfami PF01105. EMP24_GP25L. 1 hit.
[Graphical view ]
PROSITEi PS50866. GOLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiTMED9_BOVIN
AccessioniPrimary (citable) accession number: Q3T133
Secondary accession number(s): Q5E957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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