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Q3T133

- TMED9_BOVIN

UniProt

Q3T133 - TMED9_BOVIN

Protein

Transmembrane emp24 domain-containing protein 9

Gene

TMED9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 By similarity.By similarity

    GO - Biological processi

    1. COPI coating of Golgi vesicle Source: UniProtKB
    2. Golgi organization Source: UniProtKB
    3. positive regulation of organelle organization Source: UniProtKB
    4. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane emp24 domain-containing protein 9
    Alternative name(s):
    p24 family protein alpha-2
    Short name:
    p24alpha2
    Gene namesi
    Name:TMED9
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity. Golgi apparatuscis-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type I membrane protein By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Cycles between compartments of the early secretatory pathway.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: GOC
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737By similarityAdd
    BLAST
    Chaini38 – 235198Transmembrane emp24 domain-containing protein 9PRO_0000042789Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Modified residuei160 – 1601N6-acetyllysineBy similarity

    Post-translational modificationi

    N-linked glycosylated containing high mannose.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    PaxDbiQ3T133.
    PRIDEiQ3T133.

    Interactioni

    Subunit structurei

    Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. Interacts with STX17; the interaction is direct By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ3T133. 4 interactions.
    STRINGi9913.ENSBTAP00000001830.

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi231 – 2344

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4J73X-ray1.44B229-235[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini38 – 201164LumenalSequence AnalysisAdd
    BLAST
    Topological domaini223 – 23513CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 14599GOLDPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni121 – 16040Required for interaction with STX17By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili154 – 18431Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi228 – 2358COPI vesicle coat-bindingSequence Analysis
    Motifi228 – 2292COPII vesicle coat-bindingSequence Analysis

    Sequence similaritiesi

    Belongs to the EMP24/GP25L family.Curated
    Contains 1 GOLD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323830.
    GeneTreeiENSGT00430000030848.
    HOGENOMiHOG000160228.
    HOVERGENiHBG105357.
    InParanoidiQ3T133.
    OMAiVLWWSIV.
    OrthoDBiEOG74BJT2.
    TreeFamiTF314123.

    Family and domain databases

    InterProiIPR009038. GOLD.
    IPR015720. TMP21-related.
    [Graphical view]
    PANTHERiPTHR22811. PTHR22811. 1 hit.
    PfamiPF01105. EMP24_GP25L. 1 hit.
    [Graphical view]
    PROSITEiPS50866. GOLD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3T133-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAERSLWVV GLCPGSRLGR VVRVLLLLLW FAARGGALYF HIGETEKKCF    50
    IEEIPDETMV IGNYRTQLYD KQREEYQPAT PGLGMFVEVK DPEDKVILAR 100
    QYGSEGRFTF TSHTPGEHQI CLHSNSTKFS LFAGGMLRVH LDIQVGEHAN 150
    DYAEIAAKDK LSELQLRVRQ LVEQVEQIQK EQNYQRWREE RFRQTSESTN 200
    QRVLWWSILQ TLILVAIGVW QMRHLKSFFE AKKLV 235
    Length:235
    Mass (Da):27,298
    Last modified:October 11, 2005 - v1
    Checksum:i3F38C286A2021C16
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101F → I in AAX09080. (PubMed:16305752)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021063 mRNA. Translation: AAX09080.1.
    BC102145 mRNA. Translation: AAI02146.1.
    RefSeqiNP_001029984.1. NM_001034812.2.
    UniGeneiBt.8094.

    Genome annotation databases

    EnsembliENSBTAT00000001830; ENSBTAP00000001830; ENSBTAG00000001394.
    GeneIDi618580.
    KEGGibta:618580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021063 mRNA. Translation: AAX09080.1 .
    BC102145 mRNA. Translation: AAI02146.1 .
    RefSeqi NP_001029984.1. NM_001034812.2.
    UniGenei Bt.8094.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4J73 X-ray 1.44 B 229-235 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3T133. 4 interactions.
    STRINGi 9913.ENSBTAP00000001830.

    Proteomic databases

    PaxDbi Q3T133.
    PRIDEi Q3T133.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000001830 ; ENSBTAP00000001830 ; ENSBTAG00000001394 .
    GeneIDi 618580.
    KEGGi bta:618580.

    Organism-specific databases

    CTDi 54732.

    Phylogenomic databases

    eggNOGi NOG323830.
    GeneTreei ENSGT00430000030848.
    HOGENOMi HOG000160228.
    HOVERGENi HBG105357.
    InParanoidi Q3T133.
    OMAi VLWWSIV.
    OrthoDBi EOG74BJT2.
    TreeFami TF314123.

    Miscellaneous databases

    NextBioi 20901254.

    Family and domain databases

    InterProi IPR009038. GOLD.
    IPR015720. TMP21-related.
    [Graphical view ]
    PANTHERi PTHR22811. PTHR22811. 1 hit.
    Pfami PF01105. EMP24_GP25L. 1 hit.
    [Graphical view ]
    PROSITEi PS50866. GOLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiTMED9_BOVIN
    AccessioniPrimary (citable) accession number: Q3T133
    Secondary accession number(s): Q5E957
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3