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Protein

Peptidyl-tRNA hydrolase ICT1, mitochondrial

Gene

MRPL58

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.By similarity

Caution

In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, explaining the loss of codon specificity for translation release factor activity.Curated

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Ribonucleoprotein, Ribosomal protein
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-5389840 Mitochondrial translation elongation
R-BTA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC:3.1.1.29)
Alternative name(s):
39S ribosomal protein L58, mitochondrialBy similarity
Short name:
MRP-L58
Immature colon carcinoma transcript 1 protein homolog
Gene namesi
Name:MRPL58By similarity
Synonyms:ICT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:31652 MRPL58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000004575930 – 206Peptidyl-tRNA hydrolase ICT1, mitochondrialAdd BLAST177

Proteomic databases

PaxDbiQ3T116
PRIDEiQ3T116

Expressioni

Gene expression databases

BgeeiENSBTAG00000003303

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004276

Structurei

3D structure databases

ProteinModelPortaliQ3T116
SMRiQ3T116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3429 Eukaryota
COG1186 LUCA
GeneTreeiENSGT00390000013268
HOGENOMiHOG000231063
HOVERGENiHBG006115
InParanoidiQ3T116
KOiK15033
OMAiKIYPNAR
OrthoDBiEOG091G0SBR
TreeFamiTF315161

Family and domain databases

InterProiView protein in InterPro
IPR000352 Pep_chain_release_fac_I_II
PfamiView protein in Pfam
PF00472 RF-1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3T116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARCLRWG LSRAEAWLLP PPTSCCHRAL HRQVEGTEFR SAYSLDKLYP
60 70 80 90 100
ESRGADTAWR VPGDAKQGND DIPVDRLTIS YCRSSGPGGQ NVNKVNSKAE
110 120 130 140 150
VRFHLASADW IAEPVRQKMA LTHKNKINRA GELILTSEYS RYQFRNLADC
160 170 180 190 200
LQKIRDMIAE ASQPATEPSK EDAALQKLRI ENMNRERLRK KRINSAIKTS

RRVGTD
Length:206
Mass (Da):23,307
Last modified:October 11, 2005 - v1
Checksum:i1369EF2674665516
GO
Isoform 2 (identifier: Q3T116-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-62: Missing.

Show »
Length:177
Mass (Da):20,023
Checksum:i8EC1619D1AEBE398
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03921734 – 62Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102162 mRNA Translation: AAI02163.1
BC134736 mRNA Translation: AAI34737.1
RefSeqiNP_001029665.1, NM_001034493.1 [Q3T116-1]
XP_005221275.1, XM_005221218.3 [Q3T116-2]
UniGeneiBt.49175

Genome annotation databases

EnsembliENSBTAT00000004276; ENSBTAP00000004276; ENSBTAG00000003303 [Q3T116-1]
GeneIDi515465
KEGGibta:515465

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiICT1_BOVIN
AccessioniPrimary (citable) accession number: Q3T116
Secondary accession number(s): A7YWR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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