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Protein

Serine/arginine-rich splicing factor 7

Gene

SRSF7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri104 – 12017CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-109688. Cleavage of Growing Transcript in the Termination Region.
R-BTA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-BTA-72163. mRNA Splicing - Major Pathway.
R-BTA-72165. mRNA Splicing - Minor Pathway.
R-BTA-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 7
Alternative name(s):
Splicing factor, arginine/serine-rich 7
Gene namesi
Name:SRSF7
Synonyms:SFRS7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Serine/arginine-rich splicing factor 7PRO_0000284385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241N6-acetyllysineBy similarity
Modified residuei181 – 1811PhosphoserineBy similarity
Modified residuei183 – 1831PhosphoserineBy similarity
Modified residuei189 – 1891PhosphoserineBy similarity
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei193 – 1931PhosphoserineBy similarity
Modified residuei228 – 2281PhosphoserineBy similarity
Modified residuei230 – 2301PhosphoserineBy similarity

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T106.
PRIDEiQ3T106.

Interactioni

Subunit structurei

Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033048.

Structurei

3D structure databases

ProteinModelPortaliQ3T106.
SMRiQ3T106. Positions 12-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8474RRMPROSITE-ProRule annotationAdd
BLAST
Repeati153 – 16081
Repeati161 – 16882
Repeati169 – 17683
Repeati177 – 18484
Repeati208 – 21585; approximate
Repeati216 – 22386; approximate

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 9818Sufficiernt for interaction with NXF1By similarityAdd
BLAST
Regioni153 – 223716 X 8 AA repeats of R-R-S-R-S-X-S-XAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi121 – 235115Arg/Ser-rich (RS domain)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri104 – 12017CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0107. Eukaryota.
ENOG4111N8Y. LUCA.
GeneTreeiENSGT00700000104103.
HOVERGENiHBG107480.
InParanoidiQ3T106.
KOiK12896.
OMAiASPERMG.
OrthoDBiEOG73NG5V.
TreeFamiTF351858.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYGRYGGE TKVYVGNLGT GAGKGELERA FSYYGPLRTV WIARNPPGFA
60 70 80 90 100
FVEFEDPRDA EDAVRGLDGK VICGSRVRVE LSTGMPRRSR FDRPPARRPF
110 120 130 140 150
DPNDRCYECG EKGHYAYDCH RYSRRRRSRS RSRSHSRSRG RRYSRSRSRS
160 170 180 190 200
RGRRSRSASP RRSRSVSLRR SRSASLRRSR SGSIKGSRSR SRSRSRSRSL
210 220 230
SRPRSSRSKS RSPSPKRSRS PSGSPRRSAS PERVD
Length:235
Mass (Da):26,941
Last modified:October 11, 2005 - v1
Checksum:iE55CFB883E2A9822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102184 mRNA. Translation: AAI02185.1.
RefSeqiNP_001029449.1. NM_001034277.2.
UniGeneiBt.8206.

Genome annotation databases

EnsembliENSBTAT00000033124; ENSBTAP00000033048; ENSBTAG00000014891.
GeneIDi507066.
KEGGibta:507066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102184 mRNA. Translation: AAI02185.1.
RefSeqiNP_001029449.1. NM_001034277.2.
UniGeneiBt.8206.

3D structure databases

ProteinModelPortaliQ3T106.
SMRiQ3T106. Positions 12-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000033048.

Proteomic databases

PaxDbiQ3T106.
PRIDEiQ3T106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000033124; ENSBTAP00000033048; ENSBTAG00000014891.
GeneIDi507066.
KEGGibta:507066.

Organism-specific databases

CTDi6432.

Phylogenomic databases

eggNOGiKOG0107. Eukaryota.
ENOG4111N8Y. LUCA.
GeneTreeiENSGT00700000104103.
HOVERGENiHBG107480.
InParanoidiQ3T106.
KOiK12896.
OMAiASPERMG.
OrthoDBiEOG73NG5V.
TreeFamiTF351858.

Enzyme and pathway databases

ReactomeiR-BTA-109688. Cleavage of Growing Transcript in the Termination Region.
R-BTA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-BTA-72163. mRNA Splicing - Major Pathway.
R-BTA-72165. mRNA Splicing - Minor Pathway.
R-BTA-72187. mRNA 3'-end processing.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiSRSF7_BOVIN
AccessioniPrimary (citable) accession number: Q3T106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.