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Q3T100

- MGST3_BOVIN

UniProt

Q3T100 - MGST3_BOVIN

Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Also functions as a glutathione peroxidase.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: RefGenome
    2. glutathione transferase activity Source: RefGenome

    GO - Biological processi

    1. metabolic process Source: GOC
    2. oxidation-reduction process Source: GOC

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_223659. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
    Short name:
    Microsomal GST-3
    Gene namesi
    Name:MGST3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. nuclear envelope Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Microsomal glutathione S-transferase 3PRO_0000246088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi151 – 1511S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ3T100.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000013559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3T100.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84007.
    GeneTreeiENSGT00390000008608.
    HOGENOMiHOG000116372.
    HOVERGENiHBG052472.
    InParanoidiQ3T100.
    KOiK00799.
    OMAiEYGFVIL.
    OrthoDBiEOG7PCJKH.
    TreeFamiTF105328.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3T100-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLSKEYGF VILTGAASFL MVTHLAINVS KARKKYKVEY PTMYSTDPEN    50
    GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIVSGLG LAWIVGRVLY 100
    AYGYYTGEPR KRQRGALSFI ALIGLMGTTV CSAFQHLGWV RTGLNSGCKS 150
    CH 152
    Length:152
    Mass (Da):16,884
    Last modified:October 11, 2005 - v1
    Checksum:i440C63094FD1999E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102190 mRNA. Translation: AAI02191.1.
    RefSeqiNP_001030218.1. NM_001035046.2.
    XP_005203478.1. XM_005203421.1.
    UniGeneiBt.1157.

    Genome annotation databases

    EnsembliENSBTAT00000013559; ENSBTAP00000013559; ENSBTAG00000010265.
    GeneIDi507346.
    KEGGibta:507346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102190 mRNA. Translation: AAI02191.1 .
    RefSeqi NP_001030218.1. NM_001035046.2.
    XP_005203478.1. XM_005203421.1.
    UniGenei Bt.1157.

    3D structure databases

    ProteinModelPortali Q3T100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000013559.

    Proteomic databases

    PRIDEi Q3T100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013559 ; ENSBTAP00000013559 ; ENSBTAG00000010265 .
    GeneIDi 507346.
    KEGGi bta:507346.

    Organism-specific databases

    CTDi 4259.

    Phylogenomic databases

    eggNOGi NOG84007.
    GeneTreei ENSGT00390000008608.
    HOGENOMi HOG000116372.
    HOVERGENi HBG052472.
    InParanoidi Q3T100.
    KOi K00799.
    OMAi EYGFVIL.
    OrthoDBi EOG7PCJKH.
    TreeFami TF105328.

    Enzyme and pathway databases

    Reactomei REACT_223659. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 20868020.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiMGST3_BOVIN
    AccessioniPrimary (citable) accession number: Q3T100
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3