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Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Also functions as a glutathione peroxidase.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_316008. Aflatoxin activation and detoxification.
REACT_322474. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Gene namesi
Name:MGST3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Microsomal glutathione S-transferase 3PRO_0000246088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi151 – 1511S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ3T100.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013559.

Structurei

3D structure databases

ProteinModelPortaliQ3T100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84007.
GeneTreeiENSGT00390000008608.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiQ3T100.
KOiK00799.
OMAiDPENGHM.
OrthoDBiEOG7PCJKH.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLSKEYGF VILTGAASFL MVTHLAINVS KARKKYKVEY PTMYSTDPEN
60 70 80 90 100
GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIVSGLG LAWIVGRVLY
110 120 130 140 150
AYGYYTGEPR KRQRGALSFI ALIGLMGTTV CSAFQHLGWV RTGLNSGCKS

CH
Length:152
Mass (Da):16,884
Last modified:October 11, 2005 - v1
Checksum:i440C63094FD1999E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102190 mRNA. Translation: AAI02191.1.
RefSeqiNP_001030218.1. NM_001035046.2.
XP_010801016.1. XM_010802714.1.
UniGeneiBt.1157.

Genome annotation databases

EnsembliENSBTAT00000013559; ENSBTAP00000013559; ENSBTAG00000010265.
GeneIDi507346.
KEGGibta:507346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102190 mRNA. Translation: AAI02191.1.
RefSeqiNP_001030218.1. NM_001035046.2.
XP_010801016.1. XM_010802714.1.
UniGeneiBt.1157.

3D structure databases

ProteinModelPortaliQ3T100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013559.

Proteomic databases

PRIDEiQ3T100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013559; ENSBTAP00000013559; ENSBTAG00000010265.
GeneIDi507346.
KEGGibta:507346.

Organism-specific databases

CTDi4259.

Phylogenomic databases

eggNOGiNOG84007.
GeneTreeiENSGT00390000008608.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiQ3T100.
KOiK00799.
OMAiDPENGHM.
OrthoDBiEOG7PCJKH.
TreeFamiTF105328.

Enzyme and pathway databases

ReactomeiREACT_316008. Aflatoxin activation and detoxification.
REACT_322474. Glutathione conjugation.

Miscellaneous databases

NextBioi20868020.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMGST3_BOVIN
AccessioniPrimary (citable) accession number: Q3T100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.