Q3T100 (MGST3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microsomal glutathione S-transferase 3
Short name=Microsomal GST-3
EC=2.5.1.18

Gene names

Name:

MGST3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Also functions as a glutathione peroxidase By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. Microsome membrane; Multi-pass membrane protein Potential. Microsome membrane; Lipid-anchor Potential.
Sequence similarities	Belongs to the MAPEG family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione biosynthetic process Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	endoplasmic reticulum Inferred from Biological aspect of Ancestor. Source: RefGenome endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	glutathione peroxidase activity Inferred from Biological aspect of Ancestor. Source: RefGenome glutathione transferase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 152	152	Microsomal glutathione S-transferase 3		PRO_0000246088
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
Amino acid modifications
	Lipidation	151	1	S-palmitoyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T100 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 440C63094FD1999E	FASTA	152	16,884
	10 20 30 40 50 60 MAVLSKEYGF VILTGAASFL MVTHLAINVS KARKKYKVEY PTMYSTDPEN GHIFNCIQRA 70 80 90 100 110 120 HQNTLEVYPP FLFFLAVGGV YHPRIVSGLG LAWIVGRVLY AYGYYTGEPR KRQRGALSFI 130 140 150 ALIGLMGTTV CSAFQHLGWV RTGLNSGCKS CH

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102190 mRNA. Translation: AAI02191.1.
IPI	IPI00713842.
RefSeq	NP_001030218.1. NM_001035046.2.
UniGene	Bt.1157.
3D structure databases
ProteinModelPortal	Q3T100.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000013559.
Proteomic databases
PRIDE	Q3T100.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000013559; ENSBTAP00000013559; ENSBTAG00000010265.
GeneID	507346.
KEGG	bta:507346.
Organism-specific databases
CTD	4259.
Phylogenomic databases
eggNOG	NOG84007.
GeneTree	ENSGT00390000008608.
HOGENOM	HOG000116372.
HOVERGEN	HBG052472.
InParanoid	Q3T100.
KO	K00799.
OMA	EYGFVIL.
OrthoDB	EOG4FN4JZ.
Enzyme and pathway databases
BioCyc	CATTLE:507346-MONOMER.
Family and domain databases
Gene3D	1.20.120.550. 1 hit.
InterPro	IPR023352. MAPEG-like_dom. IPR001129. Membr-assoc_MAPEG. [Graphical view]
Pfam	PF01124. MAPEG. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20868020.

Entry information

Entry name

MGST3_BOVIN

Accession

Primary (citable) accession number: Q3T100

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 11, 2005
Last modified:	May 29, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program