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Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Also functions as a glutathione peroxidase.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-BTA-156590 Glutathione conjugation
R-BTA-5423646 Aflatoxin activation and detoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Gene namesi
Name:MGST3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:31453 MGST3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460881 – 152Microsomal glutathione S-transferase 3Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi151S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ3T100

Expressioni

Gene expression databases

BgeeiENSBTAG00000010265

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013559

Structurei

3D structure databases

ProteinModelPortaliQ3T100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J29S Eukaryota
ENOG4111URX LUCA
GeneTreeiENSGT00390000008608
HOGENOMiHOG000116372
HOVERGENiHBG052472
InParanoidiQ3T100
KOiK00799
OMAiQTMLFTL
OrthoDBiEOG091G0TU0
TreeFamiTF105328

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLSKEYGF VILTGAASFL MVTHLAINVS KARKKYKVEY PTMYSTDPEN
60 70 80 90 100
GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIVSGLG LAWIVGRVLY
110 120 130 140 150
AYGYYTGEPR KRQRGALSFI ALIGLMGTTV CSAFQHLGWV RTGLNSGCKS

CH
Length:152
Mass (Da):16,884
Last modified:October 11, 2005 - v1
Checksum:i440C63094FD1999E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102190 mRNA Translation: AAI02191.1
RefSeqiNP_001030218.1, NM_001035046.2
XP_010801016.1, XM_010802714.1
UniGeneiBt.1157

Genome annotation databases

EnsembliENSBTAT00000013559; ENSBTAP00000013559; ENSBTAG00000010265
GeneIDi507346
KEGGibta:507346

Similar proteinsi

Entry informationi

Entry nameiMGST3_BOVIN
AccessioniPrimary (citable) accession number: Q3T100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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