ID   DHPR_BOVIN              Reviewed;         242 AA.
AC   Q3T0Z7;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Dihydropteridine reductase;
DE            EC=1.5.1.34;
DE   AltName: Full=HDHPR;
DE   AltName: Full=Quinoid dihydropteridine reductase;
GN   Name=QDPR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The product of this enzyme, tetrahydrobiopterin (BH-4),
CC       is an essential cofactor for phenylalanine, tyrosine, and
CC       tryptophan hydroxylases (By similarity).
CC   -!- CATALYTIC ACTIVITY: A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a
CC       6,7-dihydropteridine + NAD(P)H.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BC102193; AAI02194.1; -; mRNA.
DR   IPI; IPI00714683; -.
DR   RefSeq; NP_001069960.1; -.
DR   UniGene; Bt.1735; -.
DR   SMR; Q3T0Z7; 7-240.
DR   Ensembl; ENSBTAG00000003356; Bos taurus.
DR   GeneID; 618084; -.
DR   KEGG; bta:618084; -.
DR   HOVERGEN; Q3T0Z7; -.
DR   BRENDA; 1.5.1.34; 251.
DR   GO; GO:0004155; F:6,7-dihydropteridine reductase activity; ISS:UniProtKB.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; NADP; Oxidoreductase; Tetrahydrobiopterin biosynthesis.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    242       Dihydropteridine reductase.
FT                                /FTId=PRO_0000284384.
FT   NP_BIND      12     36       NADP (By similarity).
FT   ACT_SITE    148    148       Proton acceptor (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   242 AA;  25504 MW;  C200631990475C7E CRC64;
     MAAAAGEARR VLVYGGRGAL GSRCVQAFRA RNWWVASIDV QENEEASANV VVKMTDSFTE
     QADQVTAEVG KLLGTEKVDA ILCVAGGWAG GNAKSKSLFK NCDLMWKQSV WTSTISSHLA
     TKHLKEGGLL TLAGARAALD GTPGMIGYGM AKAAVHQLCQ SLAGKSSGLP PGAAAVALLP
     VTLDTPVNRK SMPEADFSSW TPLEFLVETF HDWITEKNRP SSGSLIQVVT TEGKTELTAA
     SP
//