Reviewed, UniProtKB/Swiss-Prot Q3T0Z7 (DHPR_BOVIN)

Names and origin

Protein names

Recommended name:
    Dihydropteridine reductase
    EC=1.5.1.34
Alternative name(s):
    HDHPR
    Quinoid dihydropteridine reductase

Gene names

Name:

QDPR

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases By similarity.
Catalytic activity	A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Tetrahydrobiopterin biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrobiopterin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	6,7-dihydropteridine reductase activity Inferred from sequence or structural similarity. Source: UniProtKB binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 242	241	Dihydropteridine reductase		PRO_0000284384
Regions
	Nucleotide binding	12 – 36	25	NADP By similarity
Sites
	Active site	148	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T0Z7-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: C200631990475C7E	FASTA	242	25,504
	10 20 30 40 50 60 MAAAAGEARR VLVYGGRGAL GSRCVQAFRA RNWWVASIDV QENEEASANV VVKMTDSFTE 70 80 90 100 110 120 QADQVTAEVG KLLGTEKVDA ILCVAGGWAG GNAKSKSLFK NCDLMWKQSV WTSTISSHLA 130 140 150 160 170 180 TKHLKEGGLL TLAGARAALD GTPGMIGYGM AKAAVHQLCQ SLAGKSSGLP PGAAAVALLP 190 200 210 220 230 240 VTLDTPVNRK SMPEADFSSW TPLEFLVETF HDWITEKNRP SSGSLIQVVT TEGKTELTAA SP

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102193 mRNA. Translation: AAI02194.1.
RefSeq	NP_001069960.1.
UniGene	Bt.1735
3D structure databases
SMR	Q3T0Z7. Positions 7-240.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000003356. Bos taurus. [Contig view]
GeneID	618084.
KEGG	bta:618084.
Phylogenomic databases
HOVERGEN	Q3T0Z7.
Family and domain databases
InterPro	IPR002198. DHase_sc/Rdtase_SDR. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHPR_BOVIN

Accession

Primary (citable) accession number: Q3T0Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	October 11, 2005
Last modified:	November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)