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Protein

Lysoplasmalogenase

Gene

TMEM86B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.By similarity

Catalytic activityi

1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine.By similarity
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine.By similarity

Enzyme regulationi

Competitively inhibited by lysophosphatidic acid.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-BTA-1482788 Acyl chain remodelling of PC

Names & Taxonomyi

Protein namesi
Recommended name:
Lysoplasmalogenase (EC:3.3.2.2By similarity)
Alternative name(s):
Transmembrane protein 86B
Gene namesi
Name:TMEM86B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:36117 TMEM86B

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002018401 – 224LysoplasmalogenaseAdd BLAST224

Proteomic databases

PaxDbiQ3T0W0

Expressioni

Gene expression databases

BgeeiENSBTAG00000012189

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016167

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM86 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4804 Eukaryota
ENOG410ZQJ5 LUCA
GeneTreeiENSGT00390000007101
HOGENOMiHOG000204433
HOVERGENiHBG055092
InParanoidiQ3T0W0
KOiK18575
OMAiYFLLWIP
OrthoDBiEOG091G0LBR
TreeFamiTF324663

Family and domain databases

InterProiView protein in InterPro
IPR012506 YhhN
PANTHERiPTHR31885 PTHR31885, 1 hit
PfamiView protein in Pfam
PF07947 YhhN, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARKEGLLR KPRFSAQPRV GMGLLPFFLA CAVYLLVRNA DQPPWVNVLL
60 70 80 90 100
KILPVLYLAG FLGTAHPGGG YRALLQGALL CSAVGDACLV WPEALRYGMA
110 120 130 140 150
AFGLAHLLYL RAFGLTPLKP GLLLPLLLVS ALYFRVLHPH MPPQVVWPLL
160 170 180 190 200
AYSIVLVAML WRGLARGGSA HWGALLFVLS DSVLAWNIFT YLVPHGHLLV
210 220
MTTYYSAQML ITLSAFQNPR LKSH
Length:224
Mass (Da):24,681
Last modified:October 11, 2005 - v1
Checksum:i1AF65420176975A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102239 mRNA Translation: AAI02240.1
RefSeqiNP_001029700.1, NM_001034528.1
UniGeneiBt.30295

Genome annotation databases

EnsembliENSBTAT00000016167; ENSBTAP00000016167; ENSBTAG00000012189
GeneIDi518466
KEGGibta:518466

Similar proteinsi

Entry informationi

Entry nameiTM86B_BOVIN
AccessioniPrimary (citable) accession number: Q3T0W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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