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Protein

Lysoplasmalogenase

Gene

TMEM86B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties (By similarity).By similarity

Catalytic activityi

1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine.
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine.

Enzyme regulationi

Competitively inhibited by lysophosphatidic acid.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysoplasmalogenase (EC:3.3.2.2, EC:3.3.2.5)
Alternative name(s):
Transmembrane protein 86B
Gene namesi
Name:TMEM86B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224LysoplasmalogenasePRO_0000201840Add
BLAST

Proteomic databases

PaxDbiQ3T0W0.

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM86 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4804. Eukaryota.
ENOG410ZQJ5. LUCA.
GeneTreeiENSGT00390000007101.
HOGENOMiHOG000204433.
HOVERGENiHBG055092.
InParanoidiQ3T0W0.
KOiK18575.
OMAiILMAMLW.
OrthoDBiEOG7J9VQD.
TreeFamiTF324663.

Family and domain databases

InterProiIPR012506. YhhN.
[Graphical view]
PfamiPF07947. YhhN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARKEGLLR KPRFSAQPRV GMGLLPFFLA CAVYLLVRNA DQPPWVNVLL
60 70 80 90 100
KILPVLYLAG FLGTAHPGGG YRALLQGALL CSAVGDACLV WPEALRYGMA
110 120 130 140 150
AFGLAHLLYL RAFGLTPLKP GLLLPLLLVS ALYFRVLHPH MPPQVVWPLL
160 170 180 190 200
AYSIVLVAML WRGLARGGSA HWGALLFVLS DSVLAWNIFT YLVPHGHLLV
210 220
MTTYYSAQML ITLSAFQNPR LKSH
Length:224
Mass (Da):24,681
Last modified:October 11, 2005 - v1
Checksum:i1AF65420176975A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102239 mRNA. Translation: AAI02240.1.
RefSeqiNP_001029700.1. NM_001034528.1.
UniGeneiBt.30295.

Genome annotation databases

EnsembliENSBTAT00000016167; ENSBTAP00000016167; ENSBTAG00000012189.
GeneIDi518466.
KEGGibta:518466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102239 mRNA. Translation: AAI02240.1.
RefSeqiNP_001029700.1. NM_001034528.1.
UniGeneiBt.30295.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ3T0W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016167; ENSBTAP00000016167; ENSBTAG00000012189.
GeneIDi518466.
KEGGibta:518466.

Organism-specific databases

CTDi255043.

Phylogenomic databases

eggNOGiKOG4804. Eukaryota.
ENOG410ZQJ5. LUCA.
GeneTreeiENSGT00390000007101.
HOGENOMiHOG000204433.
HOVERGENiHBG055092.
InParanoidiQ3T0W0.
KOiK18575.
OMAiILMAMLW.
OrthoDBiEOG7J9VQD.
TreeFamiTF324663.

Family and domain databases

InterProiIPR012506. YhhN.
[Graphical view]
PfamiPF07947. YhhN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiTM86B_BOVIN
AccessioniPrimary (citable) accession number: Q3T0W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.