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Protein

Deoxyribose-phosphate aldolase

Gene

DERA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.By similarity

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (DERA)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei155Proton donor/acceptorBy similarity1
Active sitei218Schiff-base intermediate with acetaldehydeBy similarity1
Active sitei254Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-BTA-6798695 Neutrophil degranulation
R-BTA-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4By similarity)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:DERA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:28009 DERA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837981 – 318Deoxyribose-phosphate aldolaseAdd BLAST318

Proteomic databases

PaxDbiQ3T0V9
PeptideAtlasiQ3T0V9
PRIDEiQ3T0V9

Expressioni

Gene expression databases

BgeeiENSBTAG00000022167

Interactioni

Subunit structurei

Interacts with YBX1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007367

Structurei

3D structure databases

ProteinModelPortaliQ3T0V9
SMRiQ3T0V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3981 Eukaryota
COG0274 LUCA
GeneTreeiENSGT00390000007878
HOGENOMiHOG000241644
HOVERGENiHBG030164
InParanoidiQ3T0V9
KOiK01619
OMAiRYSGPDY
OrthoDBiEOG091G0CTG
TreeFamiTF314251

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
PANTHERiPTHR10889 PTHR10889, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T0V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAHQQGTEL DLSWISKIQV NKPAVLRRAE QIQARRPVKK EWQAAWLLKA
60 70 80 90 100
VTCIDLTTLS GDDTASNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC
110 120 130 140 150
VYPARVCDAV RALKAAGCDI PVASVATGFP AAQTHLKTRL EEIRLAVEDG
160 170 180 190 200
ATEIDVVINR TLVLTGQWKA LYDEIRQFRK ACGEAHLKTI LATGELGSLT
210 220 230 240 250
NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI RDFFWKTGNK
260 270 280 290 300
VGFKPAGGIR SAKDSLVWLS LIKEELGDEW MKPELFRIGA STLLADIERQ
310
IYHHVTGRYA AYHDLPMS
Length:318
Mass (Da):35,246
Last modified:October 11, 2005 - v1
Checksum:iDE1545BD35BCB714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102242 mRNA Translation: AAI02243.1
RefSeqiNP_001069496.1, NM_001076028.2
UniGeneiBt.48820

Genome annotation databases

EnsembliENSBTAT00000007367; ENSBTAP00000007367; ENSBTAG00000022167
GeneIDi534558
KEGGibta:534558

Similar proteinsi

Entry informationi

Entry nameiDEOC_BOVIN
AccessioniPrimary (citable) accession number: Q3T0V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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