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Protein

Deoxyribose-phosphate aldolase

Gene

DERA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.By similarity

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (DERA)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181Schiff-base intermediate with acetaldehydeBy similarity
Active sitei254 – 2541By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-BTA-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4By similarity)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:DERA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmic granule By similarity
  • Nucleus By similarity

  • Note: Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Deoxyribose-phosphate aldolasePRO_0000283798Add
BLAST

Proteomic databases

PaxDbiQ3T0V9.
PRIDEiQ3T0V9.

Interactioni

Subunit structurei

Interacts with YBX1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007367.

Structurei

3D structure databases

ProteinModelPortaliQ3T0V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3981. Eukaryota.
COG0274. LUCA.
GeneTreeiENSGT00390000007878.
HOGENOMiHOG000241644.
HOVERGENiHBG030164.
InParanoidiQ3T0V9.
KOiK01619.
OMAiKTLNMHD.
OrthoDBiEOG7B5WWC.
TreeFamiTF314251.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3T0V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAHQQGTEL DLSWISKIQV NKPAVLRRAE QIQARRPVKK EWQAAWLLKA
60 70 80 90 100
VTCIDLTTLS GDDTASNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC
110 120 130 140 150
VYPARVCDAV RALKAAGCDI PVASVATGFP AAQTHLKTRL EEIRLAVEDG
160 170 180 190 200
ATEIDVVINR TLVLTGQWKA LYDEIRQFRK ACGEAHLKTI LATGELGSLT
210 220 230 240 250
NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI RDFFWKTGNK
260 270 280 290 300
VGFKPAGGIR SAKDSLVWLS LIKEELGDEW MKPELFRIGA STLLADIERQ
310
IYHHVTGRYA AYHDLPMS
Length:318
Mass (Da):35,246
Last modified:October 11, 2005 - v1
Checksum:iDE1545BD35BCB714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102242 mRNA. Translation: AAI02243.1.
RefSeqiNP_001069496.1. NM_001076028.2.
UniGeneiBt.48820.

Genome annotation databases

EnsembliENSBTAT00000007367; ENSBTAP00000007367; ENSBTAG00000022167.
GeneIDi534558.
KEGGibta:534558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102242 mRNA. Translation: AAI02243.1.
RefSeqiNP_001069496.1. NM_001076028.2.
UniGeneiBt.48820.

3D structure databases

ProteinModelPortaliQ3T0V9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007367.

Proteomic databases

PaxDbiQ3T0V9.
PRIDEiQ3T0V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007367; ENSBTAP00000007367; ENSBTAG00000022167.
GeneIDi534558.
KEGGibta:534558.

Organism-specific databases

CTDi51071.

Phylogenomic databases

eggNOGiKOG3981. Eukaryota.
COG0274. LUCA.
GeneTreeiENSGT00390000007878.
HOGENOMiHOG000241644.
HOVERGENiHBG030164.
InParanoidiQ3T0V9.
KOiK01619.
OMAiKTLNMHD.
OrthoDBiEOG7B5WWC.
TreeFamiTF314251.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.
ReactomeiR-BTA-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiDEOC_BOVIN
AccessioniPrimary (citable) accession number: Q3T0V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.