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Q3T0U1 (MESD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene names
Name:MESDC2
Synonyms:MESD
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.

Subunit structure

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Domain

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.

The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similarities

Belongs to the MESD family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionChaperone
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from sequence or structural similarity. Source: UniProtKB

protein localization to cell surface

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 232201LDLR chaperone MESD
PRO_0000240318

Regions

Region1 – 162162Chaperone domain By similarity
Region163 – 20240Escort domain By similarity
Motif229 – 2324Prevents secretion from ER

Amino acid modifications

Glycosylation1991N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q3T0U1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: C5BE6CC1ADBBE8EB

FASTA23225,977
        10         20         30         40         50         60 
MAASGWARAA VIFLCACDLL LLLLLPPRAF ATEGPAETPG EATPPPRKKK KDIRDYNDAD 

        70         80         90        100        110        120 
MARLLEQWEK DDDIEEGDLP EHKRPSAPID FSQIDPGKPE SILKMTKKGK TLMMFVTVSG 

       130        140        150        160        170        180 
NPTEKETEEI TSLWQGSLFN ANYDVQRFIV GSDRAIFMLR DGGYAWEIKD FLVSQDRCAD 

       190        200        210        220        230 
VTLEGQVYPG KGGGSKEKNQ TKQEKGKKKK ERDLKPRASK EDNRAGSKKE EL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102262 mRNA. Translation: AAI02263.1.
RefSeqNP_001029641.1. NM_001034469.1.
UniGeneBt.48832.

3D structure databases

ProteinModelPortalQ3T0U1.
SMRQ3T0U1. Positions 96-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000002045.

Proteomic databases

PRIDEQ3T0U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002045; ENSBTAP00000002045; ENSBTAG00000001565.
GeneID514610.
KEGGbta:514610.

Organism-specific databases

CTD23184.

Phylogenomic databases

eggNOGNOG286690.
GeneTreeENSGT00390000000993.
HOGENOMHOG000230558.
InParanoidQ3T0U1.
OMAIVGSNRA.
OrthoDBEOG7XPZ76.
TreeFamTF315614.

Family and domain databases

InterProIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20871424.

Entry information

Entry nameMESD_BOVIN
AccessionPrimary (citable) accession number: Q3T0U1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families