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Protein

LDLR chaperone MESD

Gene

MESDC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (By similarity).By similarity

GO - Biological processi

  1. protein folding Source: UniProtKB
  2. protein localization to cell surface Source: Ensembl
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:MESDC2
Synonyms:MESD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 21

Subcellular locationi

  1. Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 232201LDLR chaperone MESDPRO_0000240318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3T0U1.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002045.

Structurei

3D structure databases

ProteinModelPortaliQ3T0U1.
SMRiQ3T0U1. Positions 96-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 162162Chaperone domainBy similarityAdd
BLAST
Regioni163 – 20240Escort domainBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi229 – 2324Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ3T0U1.
OMAiVEGQVYP.
OrthoDBiEOG7XPZ76.
TreeFamiTF315614.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGWARAA VIFLCACDLL LLLLLPPRAF ATEGPAETPG EATPPPRKKK
60 70 80 90 100
KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPID FSQIDPGKPE
110 120 130 140 150
SILKMTKKGK TLMMFVTVSG NPTEKETEEI TSLWQGSLFN ANYDVQRFIV
160 170 180 190 200
GSDRAIFMLR DGGYAWEIKD FLVSQDRCAD VTLEGQVYPG KGGGSKEKNQ
210 220 230
TKQEKGKKKK ERDLKPRASK EDNRAGSKKE EL
Length:232
Mass (Da):25,977
Last modified:October 11, 2005 - v1
Checksum:iC5BE6CC1ADBBE8EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102262 mRNA. Translation: AAI02263.1.
RefSeqiNP_001029641.1. NM_001034469.1.
UniGeneiBt.48832.

Genome annotation databases

EnsembliENSBTAT00000002045; ENSBTAP00000002045; ENSBTAG00000001565.
GeneIDi514610.
KEGGibta:514610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102262 mRNA. Translation: AAI02263.1.
RefSeqiNP_001029641.1. NM_001034469.1.
UniGeneiBt.48832.

3D structure databases

ProteinModelPortaliQ3T0U1.
SMRiQ3T0U1. Positions 96-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002045.

Proteomic databases

PRIDEiQ3T0U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002045; ENSBTAP00000002045; ENSBTAG00000001565.
GeneIDi514610.
KEGGibta:514610.

Organism-specific databases

CTDi23184.

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ3T0U1.
OMAiVEGQVYP.
OrthoDBiEOG7XPZ76.
TreeFamiTF315614.

Miscellaneous databases

NextBioi20871424.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMESD_BOVIN
AccessioniPrimary (citable) accession number: Q3T0U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.