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Q3T0U1

- MESD_BOVIN

UniProt

Q3T0U1 - MESD_BOVIN

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Protein

LDLR chaperone MESD

Gene
MESDC2, MESD
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.

GO - Biological processi

  1. protein folding Source: UniProtKB
  2. protein localization to cell surface Source: Ensembl
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LDLR chaperone MESD
Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:MESDC2
Synonyms:MESD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 21

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 232201LDLR chaperone MESDPRO_0000240318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3T0U1.

Interactioni

Subunit structurei

Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002045.

Structurei

3D structure databases

ProteinModelPortaliQ3T0U1.
SMRiQ3T0U1. Positions 96-191.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 162162Chaperone domain By similarityAdd
BLAST
Regioni163 – 20240Escort domain By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi229 – 2324Prevents secretion from ER

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6 By similarity.
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding By similarity.

Sequence similaritiesi

Belongs to the MESD family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG286690.
GeneTreeiENSGT00390000000993.
HOGENOMiHOG000230558.
InParanoidiQ3T0U1.
OMAiNQERCAD.
OrthoDBiEOG7XPZ76.
TreeFamiTF315614.

Family and domain databases

InterProiIPR019330. Mesoderm_development_cand-2.
[Graphical view]
PfamiPF10185. Mesd. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0U1-1 [UniParc]FASTAAdd to Basket

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MAASGWARAA VIFLCACDLL LLLLLPPRAF ATEGPAETPG EATPPPRKKK    50
KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPID FSQIDPGKPE 100
SILKMTKKGK TLMMFVTVSG NPTEKETEEI TSLWQGSLFN ANYDVQRFIV 150
GSDRAIFMLR DGGYAWEIKD FLVSQDRCAD VTLEGQVYPG KGGGSKEKNQ 200
TKQEKGKKKK ERDLKPRASK EDNRAGSKKE EL 232
Length:232
Mass (Da):25,977
Last modified:October 11, 2005 - v1
Checksum:iC5BE6CC1ADBBE8EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102262 mRNA. Translation: AAI02263.1.
RefSeqiNP_001029641.1. NM_001034469.1.
UniGeneiBt.48832.

Genome annotation databases

EnsembliENSBTAT00000002045; ENSBTAP00000002045; ENSBTAG00000001565.
GeneIDi514610.
KEGGibta:514610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102262 mRNA. Translation: AAI02263.1 .
RefSeqi NP_001029641.1. NM_001034469.1.
UniGenei Bt.48832.

3D structure databases

ProteinModelPortali Q3T0U1.
SMRi Q3T0U1. Positions 96-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000002045.

Proteomic databases

PRIDEi Q3T0U1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000002045 ; ENSBTAP00000002045 ; ENSBTAG00000001565 .
GeneIDi 514610.
KEGGi bta:514610.

Organism-specific databases

CTDi 23184.

Phylogenomic databases

eggNOGi NOG286690.
GeneTreei ENSGT00390000000993.
HOGENOMi HOG000230558.
InParanoidi Q3T0U1.
OMAi NQERCAD.
OrthoDBi EOG7XPZ76.
TreeFami TF315614.

Miscellaneous databases

NextBioi 20871424.

Family and domain databases

InterProi IPR019330. Mesoderm_development_cand-2.
[Graphical view ]
Pfami PF10185. Mesd. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMESD_BOVIN
AccessioniPrimary (citable) accession number: Q3T0U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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