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Protein

LRP chaperone MESD

Gene

MESD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
LRP chaperone MESDCurated
Alternative name(s):
LDLR chaperone MESD
Mesoderm development candidate 2
Mesoderm development protein
Gene namesi
Name:MESD
Synonyms:MESDC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:31392 MESD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000024031832 – 232LRP chaperone MESDAdd BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3T0U1
PeptideAtlasiQ3T0U1
PRIDEiQ3T0U1

Expressioni

Gene expression databases

BgeeiENSBTAG00000001565

Interactioni

Subunit structurei

Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002045

Structurei

3D structure databases

ProteinModelPortaliQ3T0U1
SMRiQ3T0U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 162Chaperone domainBy similarityAdd BLAST162
Regioni163 – 202Escort domainBy similarityAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi229 – 232Prevents secretion from ER4

Domaini

The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

Sequence similaritiesi

Belongs to the MESD family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4357 Eukaryota
ENOG4111SG4 LUCA
GeneTreeiENSGT00390000000993
HOGENOMiHOG000230558
InParanoidiQ3T0U1
OMAiIVGSNRA
OrthoDBiEOG091G0TTK
TreeFamiTF315614

Family and domain databases

InterProiView protein in InterPro
IPR019330 MESD
PANTHERiPTHR17600 PTHR17600, 1 hit
PfamiView protein in Pfam
PF10185 Mesd, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGWARAA VIFLCACDLL LLLLLPPRAF ATEGPAETPG EATPPPRKKK
60 70 80 90 100
KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPID FSQIDPGKPE
110 120 130 140 150
SILKMTKKGK TLMMFVTVSG NPTEKETEEI TSLWQGSLFN ANYDVQRFIV
160 170 180 190 200
GSDRAIFMLR DGGYAWEIKD FLVSQDRCAD VTLEGQVYPG KGGGSKEKNQ
210 220 230
TKQEKGKKKK ERDLKPRASK EDNRAGSKKE EL
Length:232
Mass (Da):25,977
Last modified:October 11, 2005 - v1
Checksum:iC5BE6CC1ADBBE8EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102262 mRNA Translation: AAI02263.1
RefSeqiNP_001029641.1, NM_001034469.1
UniGeneiBt.48832

Genome annotation databases

EnsembliENSBTAT00000002045; ENSBTAP00000002045; ENSBTAG00000001565
GeneIDi514610
KEGGibta:514610

Similar proteinsi

Entry informationi

Entry nameiMESD_BOVIN
AccessioniPrimary (citable) accession number: Q3T0U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health