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Q3T0U1

- MESD_BOVIN

UniProt

Q3T0U1 - MESD_BOVIN

Protein

LDLR chaperone MESD

Gene

MESDC2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction By similarity.By similarity

    GO - Biological processi

    1. protein folding Source: UniProtKB
    2. protein localization to cell surface Source: Ensembl
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LDLR chaperone MESD
    Alternative name(s):
    Mesoderm development candidate 2
    Mesoderm development protein
    Gene namesi
    Name:MESDC2
    Synonyms:MESD
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 21

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 232201LDLR chaperone MESDPRO_0000240318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ3T0U1.

    Interactioni

    Subunit structurei

    Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000002045.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3T0U1.
    SMRiQ3T0U1. Positions 96-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 162162Chaperone domainBy similarityAdd
    BLAST
    Regioni163 – 20240Escort domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi229 – 2324Prevents secretion from ER

    Domaini

    The chaperone domain provides a folding template for proper folding of the beta-propeller (BP) domains of LRP5/6.By similarity
    The escort domain ensures LRP5/6 safe-trafficking from the ER to the Golgi by preventing premature ligand-binding.By similarity

    Sequence similaritiesi

    Belongs to the MESD family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG286690.
    GeneTreeiENSGT00390000000993.
    HOGENOMiHOG000230558.
    InParanoidiQ3T0U1.
    OMAiNQERCAD.
    OrthoDBiEOG7XPZ76.
    TreeFamiTF315614.

    Family and domain databases

    InterProiIPR019330. Mesoderm_development_cand-2.
    [Graphical view]
    PfamiPF10185. Mesd. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3T0U1-1 [UniParc]FASTAAdd to Basket

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    MAASGWARAA VIFLCACDLL LLLLLPPRAF ATEGPAETPG EATPPPRKKK    50
    KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPID FSQIDPGKPE 100
    SILKMTKKGK TLMMFVTVSG NPTEKETEEI TSLWQGSLFN ANYDVQRFIV 150
    GSDRAIFMLR DGGYAWEIKD FLVSQDRCAD VTLEGQVYPG KGGGSKEKNQ 200
    TKQEKGKKKK ERDLKPRASK EDNRAGSKKE EL 232
    Length:232
    Mass (Da):25,977
    Last modified:October 11, 2005 - v1
    Checksum:iC5BE6CC1ADBBE8EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102262 mRNA. Translation: AAI02263.1.
    RefSeqiNP_001029641.1. NM_001034469.1.
    UniGeneiBt.48832.

    Genome annotation databases

    EnsembliENSBTAT00000002045; ENSBTAP00000002045; ENSBTAG00000001565.
    GeneIDi514610.
    KEGGibta:514610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102262 mRNA. Translation: AAI02263.1 .
    RefSeqi NP_001029641.1. NM_001034469.1.
    UniGenei Bt.48832.

    3D structure databases

    ProteinModelPortali Q3T0U1.
    SMRi Q3T0U1. Positions 96-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000002045.

    Proteomic databases

    PRIDEi Q3T0U1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002045 ; ENSBTAP00000002045 ; ENSBTAG00000001565 .
    GeneIDi 514610.
    KEGGi bta:514610.

    Organism-specific databases

    CTDi 23184.

    Phylogenomic databases

    eggNOGi NOG286690.
    GeneTreei ENSGT00390000000993.
    HOGENOMi HOG000230558.
    InParanoidi Q3T0U1.
    OMAi NQERCAD.
    OrthoDBi EOG7XPZ76.
    TreeFami TF315614.

    Miscellaneous databases

    NextBioi 20871424.

    Family and domain databases

    InterProi IPR019330. Mesoderm_development_cand-2.
    [Graphical view ]
    Pfami PF10185. Mesd. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiMESD_BOVIN
    AccessioniPrimary (citable) accession number: Q3T0U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3