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Q3T0T0 (GDE1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerophosphodiester phosphodiesterase 1
EC=3.1.4.44
Alternative name(s):
Membrane-interacting protein of RGS16
Gene names
Name:GDE1
Synonyms:MIR16
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways By similarity.

Catalytic activity

1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate.

Subunit structure

Interacts with PRAF2 and RGS16 By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Multi-pass membrane protein By similarity. Note: Perinuclear vesicles and cell membrane By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the glycerophosphoryl diester phosphodiesterase family.

Contains 1 GDPD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Glycerophosphodiester phosphodiesterase 1
PRO_0000251943

Regions

Topological domain1 – 22Cytoplasmic Potential
Transmembrane3 – 2321Helical; Potential
Topological domain24 – 254231Lumenal Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 33156Cytoplasmic Potential
Domain70 – 325256GDPD

Sites

Metal binding971Magnesium Potential
Metal binding991Magnesium Potential
Metal binding1741Magnesium Potential

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q3T0T0 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 852CAD36A3AF40D3

FASTA33137,653
        10         20         30         40         50         60 
MWLWEEQGGL MGPFSFLLLV LLLLTRSPFN ACLFTGSLYL LLRLFSFEPV PSRRAMQVLK 

        70         80         90        100        110        120 
PRDRVSAIAH RGGSHDAPEN TLAAIRQAAK NGAAGVELDL EFTADGIPVL MHDSTVDRTT 

       130        140        150        160        170        180 
DGTGRLCDLT FEQIRKLNPA ANHRLRNDFP NEKIPTLREA VAECLNHNLT IFFDVKGHAY 

       190        200        210        220        230        240 
KATDALKKVY MEFPKLYNNS IVCSFLPEVI YKMRQTDQNV VTALIHRPWS LSHTGDGKPR 

       250        260        270        280        290        300 
FESFWKQSMF VALDILLDWS MHNILWYLCG VSAFLAQKDF ISPDYVKKWS AKGIQVVAWT 

       310        320        330 
VNTFDEKSYY ESHLGSSYIT DSMLEDCTPE F

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC102273 mRNA. Translation: AAI02274.1.
IPIIPI00717009.
RefSeqNP_001029858.1. NM_001034686.2.
UniGeneBt.24945.

3D structure databases

ProteinModelPortalQ3T0T0.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000002710.

Proteomic databases

PRIDEQ3T0T0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002710; ENSBTAP00000002710; ENSBTAG00000002101.
GeneID539978.
KEGGbta:539978.

Organism-specific databases

CTD51573.

Phylogenomic databases

eggNOGCOG0584.
GeneTreeENSGT00510000047820.
HOGENOMHOG000006722.
HOVERGENHBG052946.
InParanoidQ3T0T0.
OMAAWTVNTF.
OrthoDBEOG4D7Z61.

Family and domain databases

Gene3D3.20.20.190. 1 hit.
InterProIPR004129. GlyceroP-diester-Pdiesterase.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
[Graphical view]
PANTHERPTHR23344. PTHR23344. 1 hit.
PfamPF03009. GDPD. 1 hit.
[Graphical view]
SUPFAMSSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
ProtoNetSearch...

Other

NextBio20878338.

Entry information

Entry nameGDE1_BOVIN
AccessionPrimary (citable) accession number: Q3T0T0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2005
Last modified: April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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