Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerophosphodiester phosphodiesterase 1

Gene

GDE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).By similarity

Catalytic activityi

1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate.By similarity
N-acyl-sn-glycero-3-phosphoethanolamine + H2O = N-acylethanolamine + sn-glycerol 3-phosphate.By similarity
1-O-(alk-1Z-enyl)-sn-glycero-3-phospho-(N-acyl)-ethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + N-acylethanolamine.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97MagnesiumSequence analysis1
Metal bindingi99MagnesiumSequence analysis1
Metal bindingi174MagnesiumSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-6814848. Glycerophospholipid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerophosphodiester phosphodiesterase 1 (EC:3.1.4.-By similarity, EC:3.1.4.44By similarity)
Alternative name(s):
Membrane-interacting protein of RGS16
Gene namesi
Name:GDE1
Synonyms:MIR16
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 254LumenalSequence analysisAdd BLAST231
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 331CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002519431 – 331Glycerophosphodiester phosphodiesterase 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3T0T0.
PRIDEiQ3T0T0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002101.

Interactioni

Subunit structurei

Interacts with PRAF2 (By similarity). Interacts with RGS16 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002710.

Structurei

3D structure databases

ProteinModelPortaliQ3T0T0.
SMRiQ3T0T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 331GP-PDEAdd BLAST267

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
GeneTreeiENSGT00510000047820.
HOGENOMiHOG000006722.
HOVERGENiHBG052946.
InParanoidiQ3T0T0.
KOiK19179.
OMAiRSPFNAC.
OrthoDBiEOG091G0ALO.
TreeFamiTF313692.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiView protein in InterPro
IPR004129. GlyceroP-diester-Pdiesterase.
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
PANTHERiPTHR23344. PTHR23344. 1 hit.
PfamiView protein in Pfam
PF03009. GDPD. 1 hit.
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiView protein in PROSITE
PS51704. GP_PDE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3T0T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLWEEQGGL MGPFSFLLLV LLLLTRSPFN ACLFTGSLYL LLRLFSFEPV
60 70 80 90 100
PSRRAMQVLK PRDRVSAIAH RGGSHDAPEN TLAAIRQAAK NGAAGVELDL
110 120 130 140 150
EFTADGIPVL MHDSTVDRTT DGTGRLCDLT FEQIRKLNPA ANHRLRNDFP
160 170 180 190 200
NEKIPTLREA VAECLNHNLT IFFDVKGHAY KATDALKKVY MEFPKLYNNS
210 220 230 240 250
IVCSFLPEVI YKMRQTDQNV VTALIHRPWS LSHTGDGKPR FESFWKQSMF
260 270 280 290 300
VALDILLDWS MHNILWYLCG VSAFLAQKDF ISPDYVKKWS AKGIQVVAWT
310 320 330
VNTFDEKSYY ESHLGSSYIT DSMLEDCTPE F
Length:331
Mass (Da):37,653
Last modified:October 11, 2005 - v1
Checksum:i852CAD36A3AF40D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102273 mRNA. Translation: AAI02274.1.
RefSeqiNP_001029858.1. NM_001034686.2.
UniGeneiBt.24945.

Genome annotation databases

EnsembliENSBTAT00000002710; ENSBTAP00000002710; ENSBTAG00000002101.
GeneIDi539978.
KEGGibta:539978.

Similar proteinsi

Entry informationi

Entry nameiGDE1_BOVIN
AccessioniPrimary (citable) accession number: Q3T0T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families