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Protein

Glycerophosphodiester phosphodiesterase 1

Gene

GDE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).By similarity

Catalytic activityi

1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971MagnesiumSequence analysis
Metal bindingi99 – 991MagnesiumSequence analysis
Metal bindingi174 – 1741MagnesiumSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-6814848. Glycerophospholipid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerophosphodiester phosphodiesterase 1 (EC:3.1.4.44)
Alternative name(s):
Membrane-interacting protein of RGS16
Gene namesi
Name:GDE1
Synonyms:MIR16
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Perinuclear vesicles and cell membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence analysis
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Topological domaini24 – 254231LumenalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Topological domaini276 – 33156CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Glycerophosphodiester phosphodiesterase 1PRO_0000251943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3T0T0.
PRIDEiQ3T0T0.

Interactioni

Subunit structurei

Interacts with PRAF2 and RGS16.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002710.

Structurei

3D structure databases

ProteinModelPortaliQ3T0T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 331267GP-PDEAdd
BLAST

Sequence similaritiesi

Contains 1 GP-PDE domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
GeneTreeiENSGT00510000047820.
HOGENOMiHOG000006722.
HOVERGENiHBG052946.
InParanoidiQ3T0T0.
KOiK19179.
OMAiSPFNACL.
OrthoDBiEOG72JWGZ.
TreeFamiTF313692.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR004129. GlyceroP-diester-Pdiesterase.
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
[Graphical view]
PANTHERiPTHR23344. PTHR23344. 1 hit.
PfamiPF03009. GDPD. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS51704. GP_PDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T0T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLWEEQGGL MGPFSFLLLV LLLLTRSPFN ACLFTGSLYL LLRLFSFEPV
60 70 80 90 100
PSRRAMQVLK PRDRVSAIAH RGGSHDAPEN TLAAIRQAAK NGAAGVELDL
110 120 130 140 150
EFTADGIPVL MHDSTVDRTT DGTGRLCDLT FEQIRKLNPA ANHRLRNDFP
160 170 180 190 200
NEKIPTLREA VAECLNHNLT IFFDVKGHAY KATDALKKVY MEFPKLYNNS
210 220 230 240 250
IVCSFLPEVI YKMRQTDQNV VTALIHRPWS LSHTGDGKPR FESFWKQSMF
260 270 280 290 300
VALDILLDWS MHNILWYLCG VSAFLAQKDF ISPDYVKKWS AKGIQVVAWT
310 320 330
VNTFDEKSYY ESHLGSSYIT DSMLEDCTPE F
Length:331
Mass (Da):37,653
Last modified:October 11, 2005 - v1
Checksum:i852CAD36A3AF40D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102273 mRNA. Translation: AAI02274.1.
RefSeqiNP_001029858.1. NM_001034686.2.
UniGeneiBt.24945.

Genome annotation databases

EnsembliENSBTAT00000002710; ENSBTAP00000002710; ENSBTAG00000002101.
GeneIDi539978.
KEGGibta:539978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102273 mRNA. Translation: AAI02274.1.
RefSeqiNP_001029858.1. NM_001034686.2.
UniGeneiBt.24945.

3D structure databases

ProteinModelPortaliQ3T0T0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002710.

Proteomic databases

PaxDbiQ3T0T0.
PRIDEiQ3T0T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002710; ENSBTAP00000002710; ENSBTAG00000002101.
GeneIDi539978.
KEGGibta:539978.

Organism-specific databases

CTDi51573.

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
GeneTreeiENSGT00510000047820.
HOGENOMiHOG000006722.
HOVERGENiHBG052946.
InParanoidiQ3T0T0.
KOiK19179.
OMAiSPFNACL.
OrthoDBiEOG72JWGZ.
TreeFamiTF313692.

Enzyme and pathway databases

ReactomeiR-BTA-6814848. Glycerophospholipid catabolism.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiIPR004129. GlyceroP-diester-Pdiesterase.
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
[Graphical view]
PANTHERiPTHR23344. PTHR23344. 1 hit.
PfamiPF03009. GDPD. 1 hit.
[Graphical view]
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiPS51704. GP_PDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiGDE1_BOVIN
AccessioniPrimary (citable) accession number: Q3T0T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.