ID   ALDOB_BOVIN             Reviewed;         364 AA.
AC   Q3T0S5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Fructose-bisphosphate aldolase B;
DE            EC=4.1.2.13;
DE   AltName: Full=Liver-type aldolase;
GN   Name=ALDOB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-fructose 1,6-bisphosphate = glycerone
CC       phosphate + D-glyceraldehyde 3-phosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 4/4.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- MISCELLANEOUS: In vertebrates, three forms of this ubiquitous
CC       glycolytic enzyme are found, aldolase A in muscle, aldolase B in
CC       liver and aldolase C in brain.
CC   -!- SIMILARITY: Belongs to the class I fructose-bisphosphate aldolase
CC       family.
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DR   EMBL; BC102278; AAI02279.1; -; mRNA.
DR   IPI; IPI00686881; -.
DR   RefSeq; NP_001029657.1; -.
DR   UniGene; Bt.46035; -.
DR   SMR; Q3T0S5; 2-364.
DR   PRIDE; Q3T0S5; -.
DR   Ensembl; ENSBTAG00000015358; Bos taurus.
DR   GeneID; 515263; -.
DR   KEGG; bta:515263; -.
DR   HOVERGEN; Q3T0S5; -.
DR   BRENDA; 4.1.2.13; 251.
DR   GO; GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:EC.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR000741; Aldolase_I.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR11627; Aldolase_I; 1.
DR   Pfam; PF00274; Glycolytic; 1.
DR   ProDom; PD001128; Aldolase_I; 1.
DR   PROSITE; PS00158; ALDOLASE_CLASS_I; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Glycolysis; Lyase; Phosphoprotein; Schiff base.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    364       Fructose-bisphosphate aldolase B.
FT                                /FTId=PRO_0000284089.
FT   ACT_SITE    188    188       Proton acceptor (By similarity).
FT   ACT_SITE    230    230       Schiff-base intermediate with
FT                                dihydroxyacetone-P (By similarity).
FT   BINDING      56     56       Substrate (By similarity).
FT   BINDING     147    147       Substrate (By similarity).
FT   SITE        364    364       Necessary for preference for fructose
FT                                1,6-bisphosphate over fructose 1-
FT                                phosphate (By similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
FT   MOD_RES      36     36       Phosphoserine (By similarity).
SQ   SEQUENCE   364 AA;  39543 MW;  935BA56BC83353EA CRC64;
     MAHQFPALTS EQKKALSETA RRIVANGKGI LAADESVGTM GNRLQRIKVE NTEENRRQFR
     ELLFTVDSSV SQSIGGVILF HETLYQKDGQ GKLFRDILKE KGIVVGIKLD QGVAPLAGTN
     KETTVQGLDG LSERCAQYKK DGADFGKWRA VLKIDNQCPS HLAIQENANT LARYASICQQ
     NGLVPIVEPE VIPDGSHDME HCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC
     TKKYTPEQVA MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF
     SYGRALQASA LAAWGGKAEN KKTTQEAFMK RALANSQAAK GQYVHMGSSG SASTQSLFTA
     SYTY
//