Q3T0S5 (ALDOB_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 58.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase B EC=4.1.2.13 Alternative name(s): Liver-type aldolase | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) [Reference proteome] | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos![]() |
Protein attributes
| Sequence length | 364 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Miscellaneous | In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. |
| Sequence similarities | Belongs to the class I fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Schiff base |
| Molecular function | Lyase |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 364 | 363 | Fructose-bisphosphate aldolase B | PRO_0000284089 | |||||
Sites | |||||||||
| Active site | 188 | 1 | Proton acceptor By similarity | ||||||
| Active site | 230 | 1 | Schiff-base intermediate with dihydroxyacetone-P By similarity | ||||||
| Binding site | 56 | 1 | Substrate By similarity | ||||||
| Binding site | 147 | 1 | Substrate By similarity | ||||||
| Site | 364 | 1 | Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
| Modified residue | 36 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC102278 mRNA. Translation: AAI02279.1. |
| IPI | IPI00686881. |
| RefSeq | NP_001029657.1. NM_001034485.2. |
| UniGene | Bt.46035. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QO5 based on UniProtKB P05062. |
| ProteinModelPortal | Q3T0S5. |
| SMR | Q3T0S5. Positions 2-364. |
| ModBase | Search... |
Proteomic databases | |
| PaxDb | Q3T0S5. |
| PRIDE | Q3T0S5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 515263. |
| KEGG | bta:515263. |
Organism-specific databases | |
| CTD | 229. |
Phylogenomic databases | |
| eggNOG | COG3588. |
| HOGENOM | HOG000220876. |
| HOVERGEN | HBG002386. |
| InParanoid | Q3T0S5. |
| KO | K01623. |
| OrthoDB | EOG444KKK. |
Enzyme and pathway databases | |
| UniPathway | UPA00109; UER00183. |
Family and domain databases | |
| Gene3D | 3.20.20.70. 1 hit. |
| InterPro | IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view] |
| PANTHER | PTHR11627. PTHR11627. 1 hit. |
| Pfam | PF00274. Glycolytic. 1 hit. [Graphical view] |
| PROSITE | PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20871739. |
Entry information
| Entry name | ALDOB_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3T0S5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
