Reviewed,
UniProtKB/Swiss-Prot Q3T0S5 (ALDOB_BOVIN)
Last modified
January 19, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase B EC=4.1.2.13 Alternative name(s): Liver-type aldolase | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 364 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Miscellaneous | In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. |
| Sequence similarities | Belongs to the class I fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Schiff base |
| Molecular function | Lyase |
| PTM | Acetylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 364 | 363 | Fructose-bisphosphate aldolase B | PRO_0000284089 | |||||
Sites | |||||||||
| Active site | 188 | 1 | Proton acceptor By similarity | ||||||
| Active site | 230 | 1 | Schiff-base intermediate with dihydroxyacetone-P By similarity | ||||||
| Binding site | 56 | 1 | Substrate By similarity | ||||||
| Binding site | 147 | 1 | Substrate By similarity | ||||||
| Site | 364 | 1 | Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
| Modified residue | 36 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC102278 mRNA. Translation: AAI02279.1. |
| IPI | IPI00686881. |
| RefSeq | NP_001029657.1. |
| UniGene | Bt.46035 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QO5 based on UniProtKB P05062. |
| SMR | Q3T0S5. Positions 2-364. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3T0S5. |
Proteomic databases | |
| PRIDE | Q3T0S5. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000020413; ENSBTAP00000020413; ENSBTAG00000015358; Bos taurus. [Genome view] |
| GeneID | 515263. |
| KEGG | bta:515263. |
Organism-specific databases | |
| CTD | 515263. |
Phylogenomic databases | |
| eggNOG | maNOG09308. |
| HOVERGEN | Q3T0S5. |
| InParanoid | Q3T0S5. |
Enzyme and pathway databases | |
| BRENDA | 4.1.2.13. 251. |
Family and domain databases | |
| InterPro | IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR11627. Aldolase_I. 1 hit. |
| Pfam | PF00274. Glycolytic. 1 hit. [Graphical view] |
| PROSITE | PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALDOB_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3T0S5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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