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Q3T0P6 (PGK1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase 1

EC=2.7.2.3
Gene names
Name:PGK1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 417416Phosphoglycerate kinase 1 HAMAP-Rule MF_00145
PRO_0000239848

Regions

Nucleotide binding373 – 3764ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue61N6-succinyllysine By similarity
Modified residue111N6-acetyllysine By similarity
Modified residue481N6-acetyllysine; alternate By similarity
Modified residue481N6-succinyllysine; alternate By similarity
Modified residue751N6-acetyllysine By similarity
Modified residue761Phosphotyrosine By similarity
Modified residue861N6-acetyllysine By similarity
Modified residue911N6-acetyllysine By similarity
Modified residue971N6-acetyllysine By similarity
Modified residue1311N6-acetyllysine; alternate By similarity
Modified residue1311N6-malonyllysine; alternate By similarity
Modified residue1461N6-acetyllysine By similarity
Modified residue1911N6-succinyllysine By similarity
Modified residue1961Phosphotyrosine By similarity
Modified residue1991N6-acetyllysine By similarity
Modified residue2031Phosphoserine By similarity
Modified residue2671N6-acetyllysine By similarity
Modified residue2911N6-acetyllysine By similarity
Modified residue3611N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3T0P6 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: DECD3DF6FBB783BD

FASTA41744,538
        10         20         30         40         50         60 
MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKYC LDSGAKSVVL 

        70         80         90        100        110        120 
MSHLGRPDGV PMPDKYSLQP VAVELKSLLG KDVLFLKDCV GPEVEKACAD PAAGSVILLE 

       130        140        150        160        170        180 
NLRFHVEEEG KGKDASGNKV KAEPTKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN 

       190        200        210        220        230        240 
LPKKAGGFLM KKELNYFAKA LESPERPFLA ILGGAKVADK IQLISNMLDK VNEMIIGGGM 

       250        260        270        280        290        300 
AFTFLKVLNN MEIGTSLFDE EGSKIVKDLM SKADKNGVKI TLPVDFVTAD KFDENAKTGQ 

       310        320        330        340        350        360 
ATVASGIPAG WMGLDCGPES SKKYAEAVAR AKQIVWNGPV GVFEWEAFAR GTKALMDEVV 

       370        380        390        400        410 
KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VDALSSV 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102308 mRNA. Translation: AAI02309.1.
RefSeqNP_001029471.1. NM_001034299.1.
UniGeneBt.37560.

3D structure databases

ProteinModelPortalQ3T0P6.
SMRQ3T0P6. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ3T0P6.
PRIDEQ3T0P6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001187; ENSBTAP00000001187; ENSBTAG00000000894.
GeneID507476.
KEGGbta:507476.

Organism-specific databases

CTD5230.

Phylogenomic databases

eggNOGCOG0126.
GeneTreeENSGT00390000008820.
HOGENOMHOG000227107.
HOVERGENHBG008177.
InParanoidQ3T0P6.
KOK00927.
OMAASCCAKW.
OrthoDBEOG74R1QN.
TreeFamTF300489.

Enzyme and pathway databases

SABIO-RKQ3T0P6.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868077.

Entry information

Entry namePGK1_BOVIN
AccessionPrimary (citable) accession number: Q3T0P6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways