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Q3T0P6

- PGK1_BOVIN

UniProt

Q3T0P6 - PGK1_BOVIN

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Protein
Phosphoglycerate kinase 1
Gene
PGK1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei313 – 3131ATP; via carbonyl oxygen By similarity
Binding sitei344 – 3441ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3764ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_224187. Glycolysis.
REACT_227222. Gluconeogenesis.
SABIO-RKQ3T0P6.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.3)
Gene namesi
Name:PGK1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 417416Phosphoglycerate kinase 1UniRule annotation
PRO_0000239848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei6 – 61N6-succinyllysine By similarity
Modified residuei11 – 111N6-acetyllysine By similarity
Modified residuei48 – 481N6-acetyllysine; alternate By similarity
Modified residuei48 – 481N6-succinyllysine; alternate By similarity
Modified residuei75 – 751N6-acetyllysine By similarity
Modified residuei76 – 761Phosphotyrosine By similarity
Modified residuei86 – 861N6-acetyllysine By similarity
Modified residuei91 – 911N6-acetyllysine By similarity
Modified residuei97 – 971N6-acetyllysine By similarity
Modified residuei131 – 1311N6-acetyllysine; alternate By similarity
Modified residuei131 – 1311N6-malonyllysine; alternate By similarity
Modified residuei146 – 1461N6-acetyllysine By similarity
Modified residuei191 – 1911N6-succinyllysine By similarity
Modified residuei196 – 1961Phosphotyrosine By similarity
Modified residuei199 – 1991N6-acetyllysine By similarity
Modified residuei203 – 2031Phosphoserine By similarity
Modified residuei267 – 2671N6-acetyllysine By similarity
Modified residuei291 – 2911N6-acetyllysine By similarity
Modified residuei361 – 3611N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T0P6.
PRIDEiQ3T0P6.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ3T0P6.
SMRiQ3T0P6. Positions 2-417.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate binding By similarity
Regioni63 – 664Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000227107.
HOVERGENiHBG008177.
InParanoidiQ3T0P6.
KOiK00927.
OMAiASCCAKW.
OrthoDBiEOG74R1QN.
TreeFamiTF300489.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0P6-1 [UniParc]FASTAAdd to Basket

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MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKYC    50
LDSGAKSVVL MSHLGRPDGV PMPDKYSLQP VAVELKSLLG KDVLFLKDCV 100
GPEVEKACAD PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPTKIEAF 150
RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPKKAGGFLM KKELNYFAKA 200
LESPERPFLA ILGGAKVADK IQLISNMLDK VNEMIIGGGM AFTFLKVLNN 250
MEIGTSLFDE EGSKIVKDLM SKADKNGVKI TLPVDFVTAD KFDENAKTGQ 300
ATVASGIPAG WMGLDCGPES SKKYAEAVAR AKQIVWNGPV GVFEWEAFAR 350
GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
ELLEGKVLPG VDALSSV 417
Length:417
Mass (Da):44,538
Last modified:January 23, 2007 - v3
Checksum:iDECD3DF6FBB783BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102308 mRNA. Translation: AAI02309.1.
RefSeqiNP_001029471.1. NM_001034299.1.
UniGeneiBt.37560.

Genome annotation databases

EnsembliENSBTAT00000001187; ENSBTAP00000001187; ENSBTAG00000000894.
GeneIDi507476.
KEGGibta:507476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102308 mRNA. Translation: AAI02309.1 .
RefSeqi NP_001029471.1. NM_001034299.1.
UniGenei Bt.37560.

3D structure databases

ProteinModelPortali Q3T0P6.
SMRi Q3T0P6. Positions 2-417.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q3T0P6.
PRIDEi Q3T0P6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000001187 ; ENSBTAP00000001187 ; ENSBTAG00000000894 .
GeneIDi 507476.
KEGGi bta:507476.

Organism-specific databases

CTDi 5230.

Phylogenomic databases

eggNOGi COG0126.
GeneTreei ENSGT00390000008820.
HOGENOMi HOG000227107.
HOVERGENi HBG008177.
InParanoidi Q3T0P6.
KOi K00927.
OMAi ASCCAKW.
OrthoDBi EOG74R1QN.
TreeFami TF300489.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
Reactomei REACT_224187. Glycolysis.
REACT_227222. Gluconeogenesis.
SABIO-RK Q3T0P6.

Miscellaneous databases

NextBioi 20868077.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiPGK1_BOVIN
AccessioniPrimary (citable) accession number: Q3T0P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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