ID   CASP6_BOVIN             Reviewed;         293 AA.
AC   Q3T0P5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Caspase-6;
DE            Short=CASP-6;
DE            EC=3.4.22.59;
DE   Contains:
DE     RecName: Full=Caspase-6 subunit p18;
DE   Contains:
DE     RecName: Full=Caspase-6 subunit p11;
DE   Flags: Precursor;
GN   Name=CASP6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the activation cascade of caspases
CC       responsible for apoptosis execution. Cleaves poly(ADP-ribose)
CC       polymerase in vitro, as well as lamins. Overexpression promotes
CC       programmed cell death (By similarity).
CC   -!- CATALYTIC ACTIVITY: Strict requirement for Asp at position P1 and
CC       has a preferred cleavage sequence of Val-Glu-His-Asp-|-.
CC   -!- ENZYME REGULATION: Activation is suppressed by phosphorylation at
CC       Ser-257 (By similarity).
CC   -!- SUBUNIT: Heterotetramer that consists of two anti-parallel
CC       arranged heterodimers, each one formed by a 18 kDa (p18) and a 11
CC       kDa (p11) subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two
CC       active subunits (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
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DR   EMBL; BC102309; AAI02310.1; -; mRNA.
DR   IPI; IPI00699138; -.
DR   RefSeq; NP_001030496.1; -.
DR   UniGene; Bt.48879; -.
DR   MEROPS; C14.005; -.
DR   Ensembl; ENSBTAG00000012537; Bos taurus.
DR   GeneID; 538409; -.
DR   KEGG; bta:538409; -.
DR   HOVERGEN; Q3T0P5; -.
DR   OMA; Q3T0P5; HERFFWH.
DR   BRENDA; 3.4.22.59; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR015469; Caspase_6.
DR   InterPro; IPR011600; Pept_C14_cat.
DR   InterPro; IPR001309; Pept_C14_ICE_p20.
DR   InterPro; IPR016129; Pept_C14_ICE_p20_AS.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR002398; Pept_C14_p45.
DR   InterPro; IPR015917; Pept_C14_p45_core.
DR   PANTHER; PTHR10454:SF29; Casp6; 1.
DR   PANTHER; PTHR10454; Pept_C14_p45; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Hydrolase; Phosphoprotein; Protease;
KW   Thiol protease; Zymogen.
FT   PROPEP        1     23       By similarity.
FT                                /FTId=PRO_0000282876.
FT   CHAIN        24    179       Caspase-6 subunit p18.
FT                                /FTId=PRO_0000282877.
FT   PROPEP      180    193       By similarity.
FT                                /FTId=PRO_0000282878.
FT   CHAIN       194    293       Caspase-6 subunit p11.
FT                                /FTId=PRO_0000282879.
FT   ACT_SITE    121    121       By similarity.
FT   ACT_SITE    163    163       By similarity.
FT   MOD_RES     257    257       Phosphoserine (By similarity).
SQ   SEQUENCE   293 AA;  33350 MW;  AC47609E52B0F00F CRC64;
     MSSEPPPRRA RGPGEEQNMT EIDAFPRREI FDPTEKYKMD HKRRGIALIF NHERFFWHLT
     LPNRPGTSAD RDNLRRRFSD LGFEVKCFDD LRAEELLLKI HEASTASHVD ADCFLCVFLS
     HGEGNHIYAY DAKIEIQTLT GLFKGDKCQS LVGKPKIFII QACRGSQHDV PVIPLDVVDH
     RTDTPDANLT QVDAASVYTL PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKFG
     SSLEFTELLT LVNRKVSQRR VDFCRDPNAI GKKQVPCFAS MLTKKLHFSP KSK
//