Reviewed, UniProtKB/Swiss-Prot Q3T0P5 (CASP6_BOVIN)

Names and origin

Protein names

Recommended name:
    Caspase-6
      Short name=CASP-6
    EC=3.4.22.59
Cleaved into the following 2 chains:
    1- Recommended name:
            Caspase-6 subunit p18
    2- Recommended name:
            Caspase-6 subunit p11

Gene names

Name:

CASP6

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death By similarity.
Catalytic activity	Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.
Enzyme regulation	Activation is suppressed by phosphorylation at Ser-257 By similarity.
Subunit structure	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits By similarity.
Sequence similarities	Belongs to the peptidase C14A family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein Zymogen
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 23	23	By similarity		PRO_0000282876
	Chain	24 – 179	156	Caspase-6 subunit p18		PRO_0000282877
	Propeptide	180 – 193	14	By similarity		PRO_0000282878
	Chain	194 – 293	100	Caspase-6 subunit p11		PRO_0000282879
Sites
	Active site	121	1	By similarity
	Active site	163	1	By similarity
Amino acid modifications
	Modified residue	257	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T0P5-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: AC47609E52B0F00F	FASTA	293	33,350
	10 20 30 40 50 60 MSSEPPPRRA RGPGEEQNMT EIDAFPRREI FDPTEKYKMD HKRRGIALIF NHERFFWHLT 70 80 90 100 110 120 LPNRPGTSAD RDNLRRRFSD LGFEVKCFDD LRAEELLLKI HEASTASHVD ADCFLCVFLS 130 140 150 160 170 180 HGEGNHIYAY DAKIEIQTLT GLFKGDKCQS LVGKPKIFII QACRGSQHDV PVIPLDVVDH 190 200 210 220 230 240 RTDTPDANLT QVDAASVYTL PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKFG 250 260 270 280 290 SSLEFTELLT LVNRKVSQRR VDFCRDPNAI GKKQVPCFAS MLTKKLHFSP KSK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102309 mRNA. Translation: AAI02310.1.
IPI	IPI00699138.
RefSeq	NP_001030496.1.
UniGene	Bt.48879
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3T0P5.
Protein family/group databases
MEROPS	C14.005.
Genome annotation databases
Ensembl	ENSBTAT00000016642; ENSBTAP00000016642; ENSBTAG00000012537; Bos taurus. [Genome view]
GeneID	538409.
KEGG	bta:538409.
Organism-specific databases
CTD	538409.
Phylogenomic databases
HOVERGEN	Q3T0P5.
OMA	HERFFWH.
Enzyme and pathway databases
BRENDA	3.4.22.59. 251.
Family and domain databases
InterPro	IPR015469. Caspase_6. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view]
PANTHER	PTHR10454:SF29. Casp6. 1 hit. PTHR10454. Pept_C14_p45. 1 hit.
Pfam	PF00656. Peptidase_C14. 1 hit. [Graphical view]
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00115. CASc. 1 hit. [Graphical view]
PROSITE	PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CASP6_BOVIN

Accession

Primary (citable) accession number: Q3T0P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 11, 2005
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)