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Protein

Caspase-6

Gene

CASP6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity).By similarity

Catalytic activityi

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

Enzyme regulationi

Activation is suppressed by phosphorylation at Ser-257.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei121 – 1211By similarity
Active sitei163 – 1631By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiC14.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-6 (EC:3.4.22.59)
Short name:
CASP-6
Cleaved into the following 2 chains:
Gene namesi
Name:CASP6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2323By similarityPRO_0000282876Add
BLAST
Chaini24 – 179156Caspase-6 subunit p18PRO_0000282877Add
BLAST
Propeptidei180 – 19314By similarityPRO_0000282878Add
BLAST
Chaini194 – 293100Caspase-6 subunit p11PRO_0000282879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei257 – 2571Phosphoserine; by NUAK1By similarity

Post-translational modificationi

Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.By similarity

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

PaxDbiQ3T0P5.
PRIDEiQ3T0P5.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016642.

Structurei

3D structure databases

ProteinModelPortaliQ3T0P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
InParanoidiQ3T0P5.
KOiK04396.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A_HD.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEPPPRRA RGPGEEQNMT EIDAFPRREI FDPTEKYKMD HKRRGIALIF
60 70 80 90 100
NHERFFWHLT LPNRPGTSAD RDNLRRRFSD LGFEVKCFDD LRAEELLLKI
110 120 130 140 150
HEASTASHVD ADCFLCVFLS HGEGNHIYAY DAKIEIQTLT GLFKGDKCQS
160 170 180 190 200
LVGKPKIFII QACRGSQHDV PVIPLDVVDH RTDTPDANLT QVDAASVYTL
210 220 230 240 250
PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKFG SSLEFTELLT
260 270 280 290
LVNRKVSQRR VDFCRDPNAI GKKQVPCFAS MLTKKLHFSP KSK
Length:293
Mass (Da):33,350
Last modified:October 11, 2005 - v1
Checksum:iAC47609E52B0F00F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102309 mRNA. Translation: AAI02310.1.
RefSeqiNP_001030496.1. NM_001035419.2.
UniGeneiBt.48879.

Genome annotation databases

GeneIDi538409.
KEGGibta:538409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102309 mRNA. Translation: AAI02310.1.
RefSeqiNP_001030496.1. NM_001035419.2.
UniGeneiBt.48879.

3D structure databases

ProteinModelPortaliQ3T0P5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016642.

Protein family/group databases

MEROPSiC14.005.

Proteomic databases

PaxDbiQ3T0P5.
PRIDEiQ3T0P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi538409.
KEGGibta:538409.

Organism-specific databases

CTDi839.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
InParanoidiQ3T0P5.
KOiK04396.

Miscellaneous databases

NextBioi20877348.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A_HD.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCASP6_BOVIN
AccessioniPrimary (citable) accession number: Q3T0P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.