Reviewed, UniProtKB/Swiss-Prot Q3T0M0 (VPS29_BOVIN)

Names and origin

Protein names

Recommended name:
    Vacuolar protein sorting-associated protein 29
    EC=3.1.3.3
Alternative name(s):
    Vesicle protein sorting 29

Gene names

Name:

VPS29

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN By similarity. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2 By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the VPS29 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Vacuolar protein sorting-associated protein 29		PRO_0000339648
Amino acid modifications
	Modified residue	54	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T0M0-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 7AA5116A30665D6F	FASTA	186	20,917
	10 20 30 40 50 60 MAGHRLVLVL GDLHIPHRCN SLPAKFKKLL VPGKIQHILC TGNLCTKESY DYLKTLAGDV 70 80 90 100 110 120 HIVRGDFDEN LNYPEQKVVT VGQFKIGLIH GHQVIPWGDM ASLALLQRQF DVDILISGHT 130 140 150 160 170 180 HKFEAFEHEN KFYINPGSAT GAYNALETNI IPSFVLMDIQ ASTVVTYVYQ LIGDDVKVER IEYKKS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102341 mRNA. Translation: AAI02342.1.
IPI	IPI00701922.
RefSeq	NP_001029627.1.
UniGene	Bt.48523
3D structure databases
SMR	Q3T0M0. Positions 6-186.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3T0M0.
Genome annotation databases
Ensembl	ENSBTAT00000011076; ENSBTAP00000011076; ENSBTAG00000008417; Bos taurus. [Genome view]
GeneID	513840.
KEGG	bta:513840.
Organism-specific databases
CTD	513840.
Phylogenomic databases
HOVERGEN	Q3T0M0.
OMA	KFEAYEH.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR000979. UPF0025. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
TIGRFAMs	TIGR00040. yfcE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VPS29_BOVIN

Accession

Primary (citable) accession number: Q3T0M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	October 11, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)