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Protein

Endoplasmic reticulum resident protein 44

Gene

ERP44

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum (By similarity).By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: GO_Central

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. glycoprotein metabolic process Source: Ensembl
  3. protein folding Source: GO_Central
  4. response to endoplasmic reticulum stress Source: GO_Central
  5. response to unfolded protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 44
Short name:
ER protein 44
Short name:
ERp44
Alternative name(s):
Thioredoxin domain-containing protein 4
Gene namesi
Name:ERP44
Synonyms:TXNDC4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 8

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. endoplasmic reticulum Source: GO_Central
  3. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  4. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  5. endoplasmic reticulum membrane Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 406377Endoplasmic reticulum resident protein 44PRO_0000239989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi189 ↔ 241By similarity
Disulfide bondi301 ↔ 318By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ3T0L2.

Interactioni

Subunit structurei

Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012930.

Structurei

3D structure databases

ProteinModelPortaliQ3T0L2.
SMRiQ3T0L2. Positions 33-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 138109ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni236 – 28550Interaction with ITPR1By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi403 – 4064Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00760000119201.
HOGENOMiHOG000007707.
InParanoidiQ3T0L2.
KOiK17264.
OMAiRHMYLFP.
OrthoDBiEOG718KCX.
TreeFamiTF106378.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGIFLSLP DLRCSLLLLV TWVFTPVTAE IISLDTENID DILNNADVAL
60 70 80 90 100
VNFYADWCRF SQMLHPIFEE ASNVIKEEYP NANQVVFARV DCDQHSDIAQ
110 120 130 140 150
RYRISKYPTL KLFRNGMMMK REYRGQRSVK ALADYIRQQK SDPIQELHDL
160 170 180 190 200
AEITTPDRSK RNIIGYFEQK DSENYRVFER VANILHDDCA FLAAFGVVSK
210 220 230 240 250
PERYSGDNIV YKPPGHSAPD MVYLGSMTNF DGTYNWIQDK CVPLVREITF
260 270 280 290 300
ENGEELTEEG LPFLILFHMK EDTESLEIFQ NEVARQLISE KGTINFLHAD
310 320 330 340 350
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFRDVLI PGKLKQFVFD
360 370 380 390 400
LHSGKLHREF HHGPDPTDTA PGEEVQDVAS SPPESSFQKL APSEYRYTLL

RDRDEL
Length:406
Mass (Da):46,836
Last modified:October 11, 2005 - v1
Checksum:i37158394A8BE4075
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102349 mRNA. Translation: AAI02350.1.
RefSeqiNP_001030204.1. NM_001035032.2.
UniGeneiBt.89221.

Genome annotation databases

EnsembliENSBTAT00000012930; ENSBTAP00000012930; ENSBTAG00000009804.
GeneIDi506157.
KEGGibta:506157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102349 mRNA. Translation: AAI02350.1.
RefSeqiNP_001030204.1. NM_001035032.2.
UniGeneiBt.89221.

3D structure databases

ProteinModelPortaliQ3T0L2.
SMRiQ3T0L2. Positions 33-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012930.

Proteomic databases

PRIDEiQ3T0L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012930; ENSBTAP00000012930; ENSBTAG00000009804.
GeneIDi506157.
KEGGibta:506157.

Organism-specific databases

CTDi23071.

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00760000119201.
HOGENOMiHOG000007707.
InParanoidiQ3T0L2.
KOiK17264.
OMAiRHMYLFP.
OrthoDBiEOG718KCX.
TreeFamiTF106378.

Miscellaneous databases

NextBioi20867475.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiERP44_BOVIN
AccessioniPrimary (citable) accession number: Q3T0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.