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Q3T0L2

- ERP44_BOVIN

UniProt

Q3T0L2 - ERP44_BOVIN

Protein

Endoplasmic reticulum resident protein 44

Gene

ERP44

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum By similarity.By similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. glycoprotein metabolic process Source: Ensembl
    3. protein folding Source: RefGenome
    4. response to endoplasmic reticulum stress Source: RefGenome
    5. response to unfolded protein Source: Ensembl

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoplasmic reticulum resident protein 44
    Short name:
    ER protein 44
    Short name:
    ERp44
    Alternative name(s):
    Thioredoxin domain-containing protein 4
    Gene namesi
    Name:ERP44
    Synonyms:TXNDC4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 8

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. endoplasmic reticulum Source: RefGenome
    3. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    4. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    5. endoplasmic reticulum membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929By similarityAdd
    BLAST
    Chaini30 – 406377Endoplasmic reticulum resident protein 44PRO_0000239989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi189 ↔ 241By similarity
    Disulfide bondi301 ↔ 318By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ3T0L2.

    Interactioni

    Subunit structurei

    Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000012930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3T0L2.
    SMRiQ3T0L2. Positions 33-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 138109ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni236 – 28550Interaction with ITPR1By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi403 – 4064Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00740000115037.
    HOGENOMiHOG000007707.
    InParanoidiQ3T0L2.
    KOiK17264.
    OMAiENAPDMV.
    OrthoDBiEOG718KCX.
    TreeFamiTF106378.

    Family and domain databases

    Gene3Di3.40.30.10. 2 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 3 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3T0L2-1 [UniParc]FASTAAdd to Basket

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    MIPGIFLSLP DLRCSLLLLV TWVFTPVTAE IISLDTENID DILNNADVAL    50
    VNFYADWCRF SQMLHPIFEE ASNVIKEEYP NANQVVFARV DCDQHSDIAQ 100
    RYRISKYPTL KLFRNGMMMK REYRGQRSVK ALADYIRQQK SDPIQELHDL 150
    AEITTPDRSK RNIIGYFEQK DSENYRVFER VANILHDDCA FLAAFGVVSK 200
    PERYSGDNIV YKPPGHSAPD MVYLGSMTNF DGTYNWIQDK CVPLVREITF 250
    ENGEELTEEG LPFLILFHMK EDTESLEIFQ NEVARQLISE KGTINFLHAD 300
    CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFRDVLI PGKLKQFVFD 350
    LHSGKLHREF HHGPDPTDTA PGEEVQDVAS SPPESSFQKL APSEYRYTLL 400
    RDRDEL 406
    Length:406
    Mass (Da):46,836
    Last modified:October 11, 2005 - v1
    Checksum:i37158394A8BE4075
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102349 mRNA. Translation: AAI02350.1.
    RefSeqiNP_001030204.1. NM_001035032.2.
    UniGeneiBt.89221.

    Genome annotation databases

    EnsembliENSBTAT00000012930; ENSBTAP00000012930; ENSBTAG00000009804.
    GeneIDi506157.
    KEGGibta:506157.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102349 mRNA. Translation: AAI02350.1 .
    RefSeqi NP_001030204.1. NM_001035032.2.
    UniGenei Bt.89221.

    3D structure databases

    ProteinModelPortali Q3T0L2.
    SMRi Q3T0L2. Positions 33-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000012930.

    Proteomic databases

    PRIDEi Q3T0L2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000012930 ; ENSBTAP00000012930 ; ENSBTAG00000009804 .
    GeneIDi 506157.
    KEGGi bta:506157.

    Organism-specific databases

    CTDi 23071.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00740000115037.
    HOGENOMi HOG000007707.
    InParanoidi Q3T0L2.
    KOi K17264.
    OMAi ENAPDMV.
    OrthoDBi EOG718KCX.
    TreeFami TF106378.

    Miscellaneous databases

    NextBioi 20867475.

    Family and domain databases

    Gene3Di 3.40.30.10. 2 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 3 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiERP44_BOVIN
    AccessioniPrimary (citable) accession number: Q3T0L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3