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Q3T0L2 (ERP44_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoplasmic reticulum resident protein 44

Short name=ER protein 44
Short name=ERp44
Alternative name(s):
Thioredoxin domain-containing protein 4
Gene names
Name:ERP44
Synonyms:TXNDC4
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum By similarity.

Subunit structure

Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 By similarity
Chain30 – 406377Endoplasmic reticulum resident protein 44
PRO_0000239989

Regions

Domain30 – 138109Thioredoxin
Region236 – 28550Interaction with ITPR1 By similarity
Motif403 – 4064Prevents secretion from ER Potential

Amino acid modifications

Disulfide bond189 ↔ 241 By similarity
Disulfide bond301 ↔ 318 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3T0L2 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 37158394A8BE4075

FASTA40646,836
        10         20         30         40         50         60 
MIPGIFLSLP DLRCSLLLLV TWVFTPVTAE IISLDTENID DILNNADVAL VNFYADWCRF 

        70         80         90        100        110        120 
SQMLHPIFEE ASNVIKEEYP NANQVVFARV DCDQHSDIAQ RYRISKYPTL KLFRNGMMMK 

       130        140        150        160        170        180 
REYRGQRSVK ALADYIRQQK SDPIQELHDL AEITTPDRSK RNIIGYFEQK DSENYRVFER 

       190        200        210        220        230        240 
VANILHDDCA FLAAFGVVSK PERYSGDNIV YKPPGHSAPD MVYLGSMTNF DGTYNWIQDK 

       250        260        270        280        290        300 
CVPLVREITF ENGEELTEEG LPFLILFHMK EDTESLEIFQ NEVARQLISE KGTINFLHAD 

       310        320        330        340        350        360 
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFRDVLI PGKLKQFVFD LHSGKLHREF 

       370        380        390        400 
HHGPDPTDTA PGEEVQDVAS SPPESSFQKL APSEYRYTLL RDRDEL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102349 mRNA. Translation: AAI02350.1.
RefSeqNP_001030204.1. NM_001035032.2.
UniGeneBt.89221.

3D structure databases

ProteinModelPortalQ3T0L2.
SMRQ3T0L2. Positions 33-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000012930.

Proteomic databases

PRIDEQ3T0L2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012930; ENSBTAP00000012930; ENSBTAG00000009804.
GeneID506157.
KEGGbta:506157.

Organism-specific databases

CTD23071.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00740000115037.
HOGENOMHOG000007707.
InParanoidQ3T0L2.
KOK17264.
OMARHMYLFP.
OrthoDBEOG718KCX.
TreeFamTF106378.

Family and domain databases

Gene3D3.40.30.10. 2 hits.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 3 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20867475.

Entry information

Entry nameERP44_BOVIN
AccessionPrimary (citable) accession number: Q3T0L2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families