ID   CATH_BOVIN              Reviewed;         335 AA.
AC   Q3T0I2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Cathepsin H;
DE            EC=3.4.22.16;
DE   Contains:
DE     RecName: Full=Cathepsin H mini chain;
DE   Contains:
DE     RecName: Full=Cathepsin H heavy chain;
DE   Contains:
DE     RecName: Full=Cathepsin H light chain;
DE   Flags: Precursor;
GN   Name=CTSH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important for the overall degradation of proteins in
CC       lysosomes (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of proteins, acting as an
CC       aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an
CC       endopeptidase.
CC   -!- SUBUNIT: Composed of a mini chain and a large chain. The large
CC       chain may be split into heavy and light chain. All chains are held
CC       together by disulfide bonds (By similarity).
CC   -!- SUBCELLULAR LOCATION: Lysosome (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
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DR   EMBL; BC102386; AAI02387.1; -; mRNA.
DR   IPI; IPI00693034; -.
DR   RefSeq; NP_001029557.1; -.
DR   UniGene; Bt.52393; -.
DR   SMR; Q3T0I2; 116-335.
DR   MEROPS; C01.040; -.
DR   Ensembl; ENSBTAG00000010992; Bos taurus.
DR   GeneID; 510524; -.
DR   KEGG; bta:510524; -.
DR   HOVERGEN; Q3T0I2; -.
DR   OMA; Q3T0I2; HHRLQTF.
DR   BRENDA; 3.4.22.16; 251.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411; Peptidase_C1A; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   ProDom; PD000158; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Signal;
KW   Thiol protease; Zymogen.
FT   SIGNAL        1     22       By similarity.
FT   PROPEP       23     97       Activation peptide (By similarity).
FT                                /FTId=PRO_0000238112.
FT   PEPTIDE      98    105       Cathepsin H mini chain.
FT                                /FTId=PRO_0000238113.
FT   PROPEP      106    115       By similarity.
FT                                /FTId=PRO_0000238114.
FT   CHAIN       116    335       Cathepsin H.
FT                                /FTId=PRO_0000238115.
FT   CHAIN       116    292       Cathepsin H heavy chain.
FT                                /FTId=PRO_0000238116.
FT   CHAIN       293    335       Cathepsin H light chain.
FT                                /FTId=PRO_0000238117.
FT   ACT_SITE    141    141       By similarity.
FT   ACT_SITE    281    281       By similarity.
FT   ACT_SITE    301    301       By similarity.
FT   CARBOHYD     72     72       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    101    101       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    230    230       N-linked (GlcNAc...) (Potential).
FT   DISULFID    102    327       By similarity.
FT   DISULFID    138    181       By similarity.
FT   DISULFID    172    214       By similarity.
FT   DISULFID    272    322       By similarity.
SQ   SEQUENCE   335 AA;  37351 MW;  79FDBEBB9984D227 CRC64;
     MWAVLPLLCA GAWLLGAPAC GAAELAANSL EKFHFQSWMV QHQKKYSSEE YYHRLQAFAS
     NLREINAHNA RNHTFKMGLN QFSDMSFDEL KRKYLWSEPQ NCSATKSNYL RGTGPYPPSM
     DWRKKGNFVT PVKNQGSCGS CWTFSTTGAL ESAVAIATGK LPFLAEQQLV DCAQNFNNHG
     CQGGLPSQAF EYIRYNKGIM GEDTYPYRGQ DGDCKYQPSK AIAFVKDVAN ITLNDEEAMV
     EAVALHNPVS FAFEVTADFM MYRKGIYSST SCHKTPDKVN HAVLAVGYGE EKGIPYWIVK
     NSWGPNWGMK GYFLIERGKN MCGLAACASF PIPLV
//