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Protein

Myotrophin

Gene

MTPN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Gene namesi
Name:MTPN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 118117MyotrophinPRO_0000240132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity
Modified residuei11 – 111N6-acetyllysineBy similarity
Modified residuei24 – 241N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3T0F7.
PRIDEiQ3T0F7.

Interactioni

Subunit structurei

Interacts with RELA. Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAPZBP791362EBI-2128107,EBI-2128126

Protein-protein interaction databases

IntActiQ3T0F7. 1 interaction.
STRINGi9913.ENSBTAP00000010269.

Structurei

3D structure databases

ProteinModelPortaliQ3T0F7.
SMRiQ3T0F7. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3029ANK 1Add
BLAST
Repeati34 – 6633ANK 2Add
BLAST
Repeati67 – 9933ANK 3Add
BLAST

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiQ3T0F7.
OMAiTALIDCT.
OrthoDBiEOG7SBNQP.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTAFEATDN QAIKALLQ
Length:118
Mass (Da):12,895
Last modified:January 23, 2007 - v3
Checksum:i9097FFDF61D329A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102413 mRNA. Translation: AAI02414.1.
RefSeqiNP_976238.2. NM_203362.2.
UniGeneiBt.63717.

Genome annotation databases

EnsembliENSBTAT00000010269; ENSBTAP00000010269; ENSBTAG00000007806.
GeneIDi541099.
KEGGibta:541099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102413 mRNA. Translation: AAI02414.1.
RefSeqiNP_976238.2. NM_203362.2.
UniGeneiBt.63717.

3D structure databases

ProteinModelPortaliQ3T0F7.
SMRiQ3T0F7. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3T0F7. 1 interaction.
STRINGi9913.ENSBTAP00000010269.

Proteomic databases

PaxDbiQ3T0F7.
PRIDEiQ3T0F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010269; ENSBTAP00000010269; ENSBTAG00000007806.
GeneIDi541099.
KEGGibta:541099.

Organism-specific databases

CTDi136319.

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiQ3T0F7.
OMAiTALIDCT.
OrthoDBiEOG7SBNQP.
TreeFamiTF327387.

Miscellaneous databases

NextBioi20879008.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiMTPN_BOVIN
AccessioniPrimary (citable) accession number: Q3T0F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.