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Protein

Myotrophin

Gene

MTPN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Gene namesi
Name:MTPN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 118117MyotrophinPRO_0000240132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity
Modified residuei11 – 111N6-acetyllysineBy similarity
Modified residuei24 – 241N6-acetyllysineBy similarity
Modified residuei31 – 311PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T0F7.
PeptideAtlasiQ3T0F7.
PRIDEiQ3T0F7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007806.

Interactioni

Subunit structurei

Interacts with RELA. Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAPZBP791362EBI-2128107,EBI-2128126

Protein-protein interaction databases

IntActiQ3T0F7. 1 interaction.
STRINGi9913.ENSBTAP00000010269.

Structurei

3D structure databases

ProteinModelPortaliQ3T0F7.
SMRiQ3T0F7. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3029ANK 1Add
BLAST
Repeati34 – 6633ANK 2Add
BLAST
Repeati67 – 9933ANK 3Add
BLAST

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiQ3T0F7.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTAFEATDN QAIKALLQ
Length:118
Mass (Da):12,895
Last modified:January 23, 2007 - v3
Checksum:i9097FFDF61D329A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102413 mRNA. Translation: AAI02414.1.
RefSeqiNP_976238.2. NM_203362.2.
UniGeneiBt.63717.

Genome annotation databases

EnsembliENSBTAT00000010269; ENSBTAP00000010269; ENSBTAG00000007806.
GeneIDi541099.
KEGGibta:541099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102413 mRNA. Translation: AAI02414.1.
RefSeqiNP_976238.2. NM_203362.2.
UniGeneiBt.63717.

3D structure databases

ProteinModelPortaliQ3T0F7.
SMRiQ3T0F7. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3T0F7. 1 interaction.
STRINGi9913.ENSBTAP00000010269.

Proteomic databases

PaxDbiQ3T0F7.
PeptideAtlasiQ3T0F7.
PRIDEiQ3T0F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010269; ENSBTAP00000010269; ENSBTAG00000007806.
GeneIDi541099.
KEGGibta:541099.

Organism-specific databases

CTDi136319.

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiQ3T0F7.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
TreeFamiTF327387.

Gene expression databases

BgeeiENSBTAG00000007806.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_BOVIN
AccessioniPrimary (citable) accession number: Q3T0F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.