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Protein

Myotrophin

Gene

MTPN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Gene namesi
Name:MTPN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:50020 MTPN

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002401322 – 118MyotrophinAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei11N6-acetyllysineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei31PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T0F7
PeptideAtlasiQ3T0F7
PRIDEiQ3T0F7

Expressioni

Gene expression databases

BgeeiENSBTAG00000007806

Interactioni

Subunit structurei

Interacts with RELA. Interacts with the heterodimer formed by CAPZA1 and CAPZB (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAPZBP791362EBI-2128107,EBI-2128126

Protein-protein interaction databases

IntActiQ3T0F7, 1 interactor
STRINGi9913.ENSBTAP00000010269

Structurei

3D structure databases

ProteinModelPortaliQ3T0F7
SMRiQ3T0F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 30ANK 1Add BLAST29
Repeati34 – 66ANK 2Add BLAST33
Repeati67 – 99ANK 3Add BLAST33

Sequence similaritiesi

Belongs to the myotrophin family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214 Eukaryota
ENOG4111U90 LUCA
GeneTreeiENSGT00430000031071
HOGENOMiHOG000276399
HOVERGENiHBG019067
InParanoidiQ3T0F7
OMAiKNIDVNQ
OrthoDBiEOG091G0Y4J
TreeFamiTF327387

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI
60 70 80 90 100
LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD
110
GLTAFEATDN QAIKALLQ
Length:118
Mass (Da):12,895
Last modified:January 23, 2007 - v3
Checksum:i9097FFDF61D329A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102413 mRNA Translation: AAI02414.1
RefSeqiNP_976238.2, NM_203362.2
UniGeneiBt.63717

Genome annotation databases

EnsembliENSBTAT00000010269; ENSBTAP00000010269; ENSBTAG00000007806
GeneIDi541099
KEGGibta:541099

Similar proteinsi

Entry informationi

Entry nameiMTPN_BOVIN
AccessioniPrimary (citable) accession number: Q3T0F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 86 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health