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Protein

Stathmin

Gene

STMN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Gene namesi
Name:STMN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001823882 – 149StathminAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei25Phosphoserine; by CDK1, MAPK1 and MAPK3By similarity1
Modified residuei29N6-methyllysineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei38Phosphoserine; by CDK1, MAPK1 and MAPK3By similarity1
Modified residuei63Phosphoserine; by PKABy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineBy similarity1

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T0C7
PeptideAtlasiQ3T0C7
PRIDEiQ3T0C7

Expressioni

Gene expression databases

BgeeiENSBTAG00000013761

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ3T0C7
STRINGi9913.ENSBTAP00000018284

Structurei

3D structure databases

ProteinModelPortaliQ3T0C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 145SLDPROSITE-ProRule annotationAdd BLAST142

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 140Sequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IN6S Eukaryota
ENOG4111KFP LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiQ3T0C7
KOiK04381
OMAiDAKSEFP
OrthoDBiEOG091G0Y2U
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHI EEVRKNKESK DPADETEAD
Length:149
Mass (Da):17,303
Last modified:January 23, 2007 - v3
Checksum:i316426F60DABCD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102453 mRNA Translation: AAI02454.1
RefSeqiNP_001029962.1, NM_001034790.2
XP_005203304.1, XM_005203247.2
XP_015316021.1, XM_015460535.1
XP_015316025.1, XM_015460539.1
UniGeneiBt.3137

Genome annotation databases

EnsembliENSBTAT00000018284; ENSBTAP00000018284; ENSBTAG00000013761
GeneIDi616317
KEGGibta:616317

Similar proteinsi

Entry informationi

Entry nameiSTMN1_BOVIN
AccessioniPrimary (citable) accession number: Q3T0C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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