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Protein

B-cell CLL/lymphoma 7 protein family member B

Gene

BCL7B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Differentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member B
Gene namesi
Name:BCL7B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:26450 BCL7B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398281 – 202B-cell CLL/lymphoma 7 protein family member BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3T0A6
PRIDEiQ3T0A6

Expressioni

Gene expression databases

BgeeiENSBTAG00000020544

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027371

Family & Domainsi

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095 Eukaryota
ENOG4111TES LUCA
GeneTreeiENSGT00390000002172
HOGENOMiHOG000232196
HOVERGENiHBG008481
InParanoidiQ3T0A6
OMAiDFTDENS
OrthoDBiEOG091G0T7O
TreeFamiTF317441

Family and domain databases

InterProiView protein in InterPro
IPR006804 BCL7
PANTHERiPTHR12767 PTHR12767, 1 hit
PfamiView protein in Pfam
PF04714 BCL_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T0A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRSVRAET RSRAKDDIKK VMAAIEKVRK WEKKWVTVGD TSLRIFKWVP
60 70 80 90 100
VTDSKEKEKS KSNSSAAREP NGFPSDASAN SSLLLEFQDE NSNQSSVSDV
110 120 130 140 150
YQLKVDSSTN SSPSPQQSES LSPAHTSDFR TDDSQPPTLG QEILEEPSLP
160 170 180 190 200
ASEVADEPPT LTKEEPVPLE TQIAEEEEDS SAPPLKRFCM DQPAVPQTAS

ES
Length:202
Mass (Da):22,197
Last modified:October 11, 2005 - v1
Checksum:i1281370D686272C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102475 mRNA Translation: AAI02476.1
RefSeqiNP_001029947.1, NM_001034775.2
UniGeneiBt.49140

Genome annotation databases

EnsembliENSBTAT00000027371; ENSBTAP00000027371; ENSBTAG00000020544
GeneIDi615062
KEGGibta:615062

Similar proteinsi

Entry informationi

Entry nameiBCL7B_BOVIN
AccessioniPrimary (citable) accession number: Q3T0A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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