Reviewed, UniProtKB/Swiss-Prot Q3T0A3 (CFAD_BOVIN)

Names and origin

Protein names

Recommended name:
    Complement factor D
    EC=3.4.21.46
Alternative name(s):
    C3 convertase activator
    Properdin factor D
    Adipsin

Gene names

Name:

CFD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway By similarity.
Catalytic activity	Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Subcellular location	Secreted.
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Biological process	Complement alternate pathway Immune response Innate immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Zymogen
Gene Ontology (GO)
Biological process	complement activation, alternative pathway Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 26	5	Activation peptide Potential		PRO_0000285859
	Chain	27 – 259	233	Complement factor D		PRO_0000285860
Regions
	Domain	27 – 254	228	Peptidase S1
Sites
	Active site	67	1	Charge relay system
	Active site	115	1	Charge relay system
	Active site	209	1	Charge relay system
Amino acid modifications
	Disulfide bond	52 ↔ 68		By similarity
	Disulfide bond	149 ↔ 215		By similarity
	Disulfide bond	180 ↔ 196		By similarity
	Disulfide bond	205 ↔ 230		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T0A3-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 0D56DB06FEC4C2A9	FASTA	259	27,878
	10 20 30 40 50 60 MADRSLHLVV LILLGTALCA AQPRGRILRG QEAPSHSRPY MASVQVNGKH VCGGFLIAEQ 70 80 90 100 110 120 WVMSAAHCLE DVADGKVQVL LGAHSLSQPE PSKRLYDVLR VVPHPGSRTE TIDHDLLLLQ 130 140 150 160 170 180 LSEKAVLGPA VQLLPWQRED RDVAAGTLCD VAGWGVVSHT GRKPDRLQHL LLPVLDRATC 190 200 210 220 230 240 NLRTYHDGTI TERMMCAESN RRDTCKGDSG GPLVCGSVAE GVVTSGSRIC GNHKKPGIYT 250 RLASYVAWID GVMAEGAAA

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102479 mRNA. Translation: AAI02480.1.
IPI	IPI00686338.
RefSeq	NP_001029427.1.
UniGene	Bt.41326
3D structure databases
SMR	Q3T0A3. Positions 27-254.
ModBase	Search...
Genome annotation databases
GeneID	505647.
KEGG	bta:505647.
Phylogenomic databases
HOVERGEN	Q3T0A3.
Enzyme and pathway databases
BRENDA	3.4.21.46. 251.
Family and domain databases
InterPro	IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CFAD_BOVIN

Accession

Primary (citable) accession number: Q3T0A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)