ID   SYWM_BOVIN              Reviewed;         360 AA.
AC   Q3T099;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Tryptophanyl-tRNA synthetase, mitochondrial;
DE            EC=6.1.1.2;
DE   AltName: Full=Tryptophan--tRNA ligase;
DE            Short=TrpRS;
DE   AltName: Full=(Mt)TrpRS;
DE   Flags: Precursor;
GN   Name=WARS2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-tryptophan + tRNA(Trp) = AMP +
CC       diphosphate + L-tryptophyl-tRNA(Trp).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase
CC       family.
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DR   EMBL; BC102487; AAI02488.1; -; mRNA.
DR   IPI; IPI00705195; -.
DR   RefSeq; NP_001029754.1; -.
DR   UniGene; Bt.49042; -.
DR   Ensembl; ENSBTAG00000005064; Bos taurus.
DR   GeneID; 532903; -.
DR   KEGG; bta:532903; -.
DR   HOVERGEN; Q3T099; -.
DR   OMA; Q3T099; NKPGVSN.
DR   BRENDA; 6.1.1.2; 251.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:EC.
DR   GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002305; aa-tRNA-synth_Ib.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR002306; Trp-tRNA-synth_Ib.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   PANTHER; PTHR10055; Trp_tRNA-synt_1b; 1.
DR   Pfam; PF00579; tRNA-synt_1b; 1.
DR   PRINTS; PR01039; TRNASYNTHTRP.
DR   TIGRFAMs; TIGR00233; trpS; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   2: Evidence at transcript level;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Ligase; Mitochondrion;
KW   Nucleotide-binding; Protein biosynthesis; Transit peptide.
FT   TRANSIT       1     18       Mitochondrion (By similarity).
FT   CHAIN        19    360       Tryptophanyl-tRNA synthetase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000254589.
SQ   SEQUENCE   360 AA;  40205 MW;  B7B3116B6619C952 CRC64;
     MALRSMRKAR ECWNFIRALH QGPDAAPVPQ KDAVKRIFSG IQPTGIPHLG NYLGAIESWV
     RLQDEHDSVL YSIVDLHSIT VPQDPTILRQ SILDMTAALL ACGINPEKSI LFQQSQVSEH
     TQLSWILTCM VRLPRLQHLH QWKAKTAKEK HNGTVGLLTY PVLQAADILL YKSTHVPVGE
     DQVQHMELVQ DLAQSFNKKY GEFFPVPKSI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI
     TDSPEEIVQK FRKAMTDFTS EVTYEPASRG GVSNLVAIHA AVAGLPVEEV VRRSAGMDTA
     RYKLVVADAV IEKFAPIKSE IEKLKMNKDH LEKVLQVGSA RAKELAYPVC QEVKKLVGFL
//