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Q3T099

- SYWM_BOVIN

UniProt

Q3T099 - SYWM_BOVIN

Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

WARS2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: InterPro
    2. vasculogenesis Source: Ensembl

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_209854. Mitochondrial tRNA aminoacylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
    Alternative name(s):
    (Mt)TrpRS
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:WARS2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1818MitochondrionBy similarityAdd
    BLAST
    Chaini19 – 360342Tryptophan--tRNA ligase, mitochondrialPRO_0000254589Add
    BLAST

    Proteomic databases

    PRIDEiQ3T099.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000006675.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3T099.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0180.
    GeneTreeiENSGT00510000047425.
    HOGENOMiHOG000059940.
    HOVERGENiHBG027444.
    InParanoidiQ3T099.
    KOiK01867.
    OMAiSHILHRP.
    OrthoDBiEOG7J447N.
    TreeFamiTF314321.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3T099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRSMRKAR ECWNFIRALH QGPDAAPVPQ KDAVKRIFSG IQPTGIPHLG    50
    NYLGAIESWV RLQDEHDSVL YSIVDLHSIT VPQDPTILRQ SILDMTAALL 100
    ACGINPEKSI LFQQSQVSEH TQLSWILTCM VRLPRLQHLH QWKAKTAKEK 150
    HNGTVGLLTY PVLQAADILL YKSTHVPVGE DQVQHMELVQ DLAQSFNKKY 200
    GEFFPVPKSI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI TDSPEEIVQK 250
    FRKAMTDFTS EVTYEPASRG GVSNLVAIHA AVAGLPVEEV VRRSAGMDTA 300
    RYKLVVADAV IEKFAPIKSE IEKLKMNKDH LEKVLQVGSA RAKELAYPVC 350
    QEVKKLVGFL 360
    Length:360
    Mass (Da):40,205
    Last modified:October 11, 2005 - v1
    Checksum:iB7B3116B6619C952
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102487 mRNA. Translation: AAI02488.1.
    RefSeqiNP_001029754.1. NM_001034582.2.
    UniGeneiBt.49042.

    Genome annotation databases

    EnsembliENSBTAT00000006675; ENSBTAP00000006675; ENSBTAG00000005064.
    GeneIDi532903.
    KEGGibta:532903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102487 mRNA. Translation: AAI02488.1 .
    RefSeqi NP_001029754.1. NM_001034582.2.
    UniGenei Bt.49042.

    3D structure databases

    ProteinModelPortali Q3T099.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000006675.

    Proteomic databases

    PRIDEi Q3T099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006675 ; ENSBTAP00000006675 ; ENSBTAG00000005064 .
    GeneIDi 532903.
    KEGGi bta:532903.

    Organism-specific databases

    CTDi 10352.

    Phylogenomic databases

    eggNOGi COG0180.
    GeneTreei ENSGT00510000047425.
    HOGENOMi HOG000059940.
    HOVERGENi HBG027444.
    InParanoidi Q3T099.
    KOi K01867.
    OMAi SHILHRP.
    OrthoDBi EOG7J447N.
    TreeFami TF314321.

    Enzyme and pathway databases

    Reactomei REACT_209854. Mitochondrial tRNA aminoacylation.

    Miscellaneous databases

    NextBioi 20875845.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiSYWM_BOVIN
    AccessioniPrimary (citable) accession number: Q3T099
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3