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Q3T099 (SYWM_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase, mitochondrial

EC=6.1.1.2
Alternative name(s):
(Mt)TrpRS
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:WARS2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140_B

Subcellular location

Mitochondrion matrix HAMAP-Rule MF_00140_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1818Mitochondrion By similarity
Chain19 – 360342Tryptophan--tRNA ligase, mitochondrial HAMAP-Rule MF_00140_B
PRO_0000254589

Sequences

Sequence LengthMass (Da)Tools
Q3T099 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: B7B3116B6619C952

FASTA36040,205
        10         20         30         40         50         60 
MALRSMRKAR ECWNFIRALH QGPDAAPVPQ KDAVKRIFSG IQPTGIPHLG NYLGAIESWV 

        70         80         90        100        110        120 
RLQDEHDSVL YSIVDLHSIT VPQDPTILRQ SILDMTAALL ACGINPEKSI LFQQSQVSEH 

       130        140        150        160        170        180 
TQLSWILTCM VRLPRLQHLH QWKAKTAKEK HNGTVGLLTY PVLQAADILL YKSTHVPVGE 

       190        200        210        220        230        240 
DQVQHMELVQ DLAQSFNKKY GEFFPVPKSI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI 

       250        260        270        280        290        300 
TDSPEEIVQK FRKAMTDFTS EVTYEPASRG GVSNLVAIHA AVAGLPVEEV VRRSAGMDTA 

       310        320        330        340        350        360 
RYKLVVADAV IEKFAPIKSE IEKLKMNKDH LEKVLQVGSA RAKELAYPVC QEVKKLVGFL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102487 mRNA. Translation: AAI02488.1.
RefSeqNP_001029754.1. NM_001034582.2.
UniGeneBt.49042.

3D structure databases

ProteinModelPortalQ3T099.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000006675.

Proteomic databases

PRIDEQ3T099.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000006675; ENSBTAP00000006675; ENSBTAG00000005064.
GeneID532903.
KEGGbta:532903.

Organism-specific databases

CTD10352.

Phylogenomic databases

eggNOGCOG0180.
GeneTreeENSGT00510000047425.
HOGENOMHOG000059940.
HOVERGENHBG027444.
InParanoidQ3T099.
KOK01867.
OMASHILHRP.
OrthoDBEOG7J447N.
TreeFamTF314321.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20875845.

Entry information

Entry nameSYWM_BOVIN
AccessionPrimary (citable) accession number: Q3T099
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries