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Q3T099

- SYWM_BOVIN

UniProt

Q3T099 - SYWM_BOVIN

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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

WARS2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: InterPro
  2. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_209854. Mitochondrial tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
(Mt)TrpRS
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:WARS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionBy similarityAdd
BLAST
Chaini19 – 360342Tryptophan--tRNA ligase, mitochondrialPRO_0000254589Add
BLAST

Proteomic databases

PRIDEiQ3T099.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006675.

Structurei

3D structure databases

ProteinModelPortaliQ3T099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0180.
GeneTreeiENSGT00510000047425.
HOGENOMiHOG000059940.
HOVERGENiHBG027444.
InParanoidiQ3T099.
KOiK01867.
OMAiSHILHRP.
OrthoDBiEOG7J447N.
TreeFamiTF314321.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T099-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRSMRKAR ECWNFIRALH QGPDAAPVPQ KDAVKRIFSG IQPTGIPHLG
60 70 80 90 100
NYLGAIESWV RLQDEHDSVL YSIVDLHSIT VPQDPTILRQ SILDMTAALL
110 120 130 140 150
ACGINPEKSI LFQQSQVSEH TQLSWILTCM VRLPRLQHLH QWKAKTAKEK
160 170 180 190 200
HNGTVGLLTY PVLQAADILL YKSTHVPVGE DQVQHMELVQ DLAQSFNKKY
210 220 230 240 250
GEFFPVPKSI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI TDSPEEIVQK
260 270 280 290 300
FRKAMTDFTS EVTYEPASRG GVSNLVAIHA AVAGLPVEEV VRRSAGMDTA
310 320 330 340 350
RYKLVVADAV IEKFAPIKSE IEKLKMNKDH LEKVLQVGSA RAKELAYPVC
360
QEVKKLVGFL
Length:360
Mass (Da):40,205
Last modified:October 11, 2005 - v1
Checksum:iB7B3116B6619C952
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102487 mRNA. Translation: AAI02488.1.
RefSeqiNP_001029754.1. NM_001034582.2.
UniGeneiBt.49042.

Genome annotation databases

EnsembliENSBTAT00000006675; ENSBTAP00000006675; ENSBTAG00000005064.
GeneIDi532903.
KEGGibta:532903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102487 mRNA. Translation: AAI02488.1 .
RefSeqi NP_001029754.1. NM_001034582.2.
UniGenei Bt.49042.

3D structure databases

ProteinModelPortali Q3T099.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000006675.

Proteomic databases

PRIDEi Q3T099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006675 ; ENSBTAP00000006675 ; ENSBTAG00000005064 .
GeneIDi 532903.
KEGGi bta:532903.

Organism-specific databases

CTDi 10352.

Phylogenomic databases

eggNOGi COG0180.
GeneTreei ENSGT00510000047425.
HOGENOMi HOG000059940.
HOVERGENi HBG027444.
InParanoidi Q3T099.
KOi K01867.
OMAi SHILHRP.
OrthoDBi EOG7J447N.
TreeFami TF314321.

Enzyme and pathway databases

Reactomei REACT_209854. Mitochondrial tRNA aminoacylation.

Miscellaneous databases

NextBioi 20875845.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiSYWM_BOVIN
AccessioniPrimary (citable) accession number: Q3T099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3