Reviewed, UniProtKB/Swiss-Prot Q3T099 (SYWM_BOVIN)

Names and origin

Protein names

Recommended name:
    Tryptophanyl-tRNA synthetase, mitochondrial
    EC=6.1.1.2
Alternative name(s):
    Tryptophan--tRNA ligase
      Short name=TrpRS
    (Mt)TrpRS

Gene names

Name:

WARS2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	tryptophanyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tryptophan-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 18	18	Mitochondrion By similarity
	Chain	19 – 360	342	Tryptophanyl-tRNA synthetase, mitochondrial		PRO_0000254589

Sequences

	Sequence		Length	Mass (Da)
	Q3T099-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: B7B3116B6619C952	FASTA	360	40,205
	10 20 30 40 50 60 MALRSMRKAR ECWNFIRALH QGPDAAPVPQ KDAVKRIFSG IQPTGIPHLG NYLGAIESWV 70 80 90 100 110 120 RLQDEHDSVL YSIVDLHSIT VPQDPTILRQ SILDMTAALL ACGINPEKSI LFQQSQVSEH 130 140 150 160 170 180 TQLSWILTCM VRLPRLQHLH QWKAKTAKEK HNGTVGLLTY PVLQAADILL YKSTHVPVGE 190 200 210 220 230 240 DQVQHMELVQ DLAQSFNKKY GEFFPVPKSI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI 250 260 270 280 290 300 TDSPEEIVQK FRKAMTDFTS EVTYEPASRG GVSNLVAIHA AVAGLPVEEV VRRSAGMDTA 310 320 330 340 350 360 RYKLVVADAV IEKFAPIKSE IEKLKMNKDH LEKVLQVGSA RAKELAYPVC QEVKKLVGFL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102487 mRNA. Translation: AAI02488.1.
IPI	IPI00705195.
RefSeq	NP_001029754.1.
UniGene	Bt.49042
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000005064. Bos taurus. [Contig view]
GeneID	532903.
KEGG	bta:532903.
Phylogenomic databases
HOVERGEN	Q3T099.
OMA	Q3T099. NKPGVSN.
Enzyme and pathway databases
BRENDA	6.1.1.2. 251.
Family and domain databases
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR002305. aa-tRNA-synth_Ib. IPR014729. Rossmann-like_a/b/a_fold. IPR002306. Trp-tRNA-synth_Ib. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR10055. Trp_tRNA-synt_1b. 1 hit.
Pfam	PF00579. tRNA-synt_1b. 1 hit. [Graphical view]
PRINTS	PR01039. TRNASYNTHTRP.
TIGRFAMs	TIGR00233. trpS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYWM_BOVIN

Accession

Primary (citable) accession number: Q3T099

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 11, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)