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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

WARS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.By similarity

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPBy similarity1
Binding sitei167L-tryptophanBy similarity1
Binding sitei217ATP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 51ATPBy similarity4
Nucleotide bindingi179 – 181ATPBy similarity3
Nucleotide bindingi226 – 230ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
(Mt)TrpRS
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:WARS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:36864 WARS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionBy similarityAdd BLAST18
ChainiPRO_000025458919 – 360Tryptophan--tRNA ligase, mitochondrialAdd BLAST342

Proteomic databases

PaxDbiQ3T099
PRIDEiQ3T099

Expressioni

Gene expression databases

BgeeiENSBTAG00000005064

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006675

Structurei

3D structure databases

ProteinModelPortaliQ3T099
SMRiQ3T099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2713 Eukaryota
COG0180 LUCA
GeneTreeiENSGT00510000047425
HOGENOMiHOG000059940
HOVERGENiHBG027444
InParanoidiQ3T099
KOiK01867
OMAiQRMTQFK
OrthoDBiEOG091G04TZ
TreeFamiTF314321

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRSMRKAR ECWNFIRALH QGPDAAPVPQ KDAVKRIFSG IQPTGIPHLG
60 70 80 90 100
NYLGAIESWV RLQDEHDSVL YSIVDLHSIT VPQDPTILRQ SILDMTAALL
110 120 130 140 150
ACGINPEKSI LFQQSQVSEH TQLSWILTCM VRLPRLQHLH QWKAKTAKEK
160 170 180 190 200
HNGTVGLLTY PVLQAADILL YKSTHVPVGE DQVQHMELVQ DLAQSFNKKY
210 220 230 240 250
GEFFPVPKSI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI TDSPEEIVQK
260 270 280 290 300
FRKAMTDFTS EVTYEPASRG GVSNLVAIHA AVAGLPVEEV VRRSAGMDTA
310 320 330 340 350
RYKLVVADAV IEKFAPIKSE IEKLKMNKDH LEKVLQVGSA RAKELAYPVC
360
QEVKKLVGFL
Length:360
Mass (Da):40,205
Last modified:October 11, 2005 - v1
Checksum:iB7B3116B6619C952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102487 mRNA Translation: AAI02488.1
RefSeqiNP_001029754.1, NM_001034582.2
UniGeneiBt.49042

Genome annotation databases

EnsembliENSBTAT00000006675; ENSBTAP00000006675; ENSBTAG00000005064
GeneIDi532903
KEGGibta:532903

Similar proteinsi

Entry informationi

Entry nameiSYWM_BOVIN
AccessioniPrimary (citable) accession number: Q3T099
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health