ID   SCPDH_BOVIN             Reviewed;         429 AA.
AC   Q3T067;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Probable saccharopine dehydrogenase;
DE            EC=1.5.1.9;
GN   Name=SCCPDH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+)
CC       + H(2)O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-lysine degradation via
CC       saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.
CC   -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
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DR   EMBL; BC102545; AAI02546.1; -; mRNA.
DR   IPI; IPI00706311; -.
DR   RefSeq; NP_001029460.1; -.
DR   UniGene; Bt.27130; -.
DR   Ensembl; ENSBTAG00000003804; Bos taurus.
DR   GeneID; 507289; -.
DR   KEGG; bta:507289; -.
DR   HOVERGEN; Q3T067; -.
DR   BRENDA; 1.5.1.9; 251.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0047131; F:saccharopine dehydrogenase (NAD+, L-glutama...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR005097; Saccharopine_DH.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF03435; Saccharop_dh; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    429       Probable saccharopine dehydrogenase.
FT                                /FTId=PRO_0000290019.
SQ   SEQUENCE   429 AA;  47320 MW;  B989FF43A0887738 CRC64;
     MATQQRPFHL VVFGASGFTG QFVTEEVARE QVSPERTSHL PWAVAGRSRE KLLRVLERAA
     MKLGRPTLSS EVGIIICDIT NPASLDEMAK QATVVLNCVG PYRFYGEPVI KACIENGTSC
     IDISGEPQFL ELMYWKYHEK AAEKGVYIIG SSGFDSIPAD LGVIYTRNKM NGTLTAVESF
     LTISSGPEGL CVHDGTWKSA VYGFGDKSNL KKLRNESDMK PVPIVGPKLK RRWPISYCRE
     LNSYSIPFLG ADVSVVKRTQ RYLHENLEQS PVQYAAYINV GGITSVIKLM FAGLFFLFFV
     RFGIGRQLLI KFTWLFSFGY FSKQGPTQKQ IDASSFTMTF FGQGFSQGVS PVKNKPNIRI
     CTQVKGPEAG YVSTSIAMVQ AAMILLNDAS DLPKAGGVFT PGAAFSRTKL IDRLNEHGIE
     FSVISSTEV
//