Reviewed, UniProtKB/Swiss-Prot Q3T067 (SCPDH_BOVIN)

Names and origin

Protein names

Recommended name:
    Probable saccharopine dehydrogenase
    EC=1.5.1.9

Gene names

Name:

SCCPDH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH.
Pathway	Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.
Sequence similarities	Belongs to the saccharopine dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 429	428	Probable saccharopine dehydrogenase		PRO_0000290019
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T067-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: B989FF43A0887738	FASTA	429	47,320
	10 20 30 40 50 60 MATQQRPFHL VVFGASGFTG QFVTEEVARE QVSPERTSHL PWAVAGRSRE KLLRVLERAA 70 80 90 100 110 120 MKLGRPTLSS EVGIIICDIT NPASLDEMAK QATVVLNCVG PYRFYGEPVI KACIENGTSC 130 140 150 160 170 180 IDISGEPQFL ELMYWKYHEK AAEKGVYIIG SSGFDSIPAD LGVIYTRNKM NGTLTAVESF 190 200 210 220 230 240 LTISSGPEGL CVHDGTWKSA VYGFGDKSNL KKLRNESDMK PVPIVGPKLK RRWPISYCRE 250 260 270 280 290 300 LNSYSIPFLG ADVSVVKRTQ RYLHENLEQS PVQYAAYINV GGITSVIKLM FAGLFFLFFV 310 320 330 340 350 360 RFGIGRQLLI KFTWLFSFGY FSKQGPTQKQ IDASSFTMTF FGQGFSQGVS PVKNKPNIRI 370 380 390 400 410 420 CTQVKGPEAG YVSTSIAMVQ AAMILLNDAS DLPKAGGVFT PGAAFSRTKL IDRLNEHGIE FSVISSTEV

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102545 mRNA. Translation: AAI02546.1.
IPI	IPI00706311.
RefSeq	NP_001029460.1.
UniGene	Bt.27130
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3T067.
Genome annotation databases
Ensembl	ENSBTAT00000004949; ENSBTAP00000004949; ENSBTAG00000003804; Bos taurus. [Genome view]
GeneID	507289.
KEGG	bta:507289.
Organism-specific databases
CTD	507289.
Phylogenomic databases
eggNOG	maNOG09456.
HOVERGEN	Q3T067.
InParanoid	Q3T067.
Enzyme and pathway databases
BRENDA	1.5.1.9. 251.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR005097. Saccharopine_DH/HSpermid_syn. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF03435. Saccharop_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCPDH_BOVIN

Accession

Primary (citable) accession number: Q3T067

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	October 11, 2005
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)