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Protein

Cytochrome c oxidase subunit 7A-related protein, mitochondrial

Gene

COX7A2L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-related protein
Gene namesi
Name:COX7A2L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5555MitochondrionSequence analysisAdd
BLAST
Chaini56 – 11459Cytochrome c oxidase subunit 7A-related protein, mitochondrialPRO_0000247326Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3T061.
PeptideAtlasiQ3T061.
PRIDEiQ3T061.

Interactioni

Subunit structurei

Interacts with the mitochondrial respiratory supercomplex.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000943.

Structurei

3D structure databases

ProteinModelPortaliQ3T061.
SMRiQ3T061. Positions 57-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IYMH. Eukaryota.
ENOG41120Z9. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiQ3T061.
KOiK02270.
OMAiYFAAQPN.
OrthoDBiEOG7BGHNV.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
IPR017267. Cyt_c_oxidase_su7a-rel_mt.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PTHR10510:SF2. PTHR10510:SF2. 1 hit.
PIRSFiPIRSF037710. COX7A-rel_mt. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYKFSGFTQ KLAGAWASDA YSPQGLRPVV STEAPPIIFA TPTKLSSGPT
60 70 80 90 100
AYDYAGKNTV PELQKFFQKS DGVPIHLKRG LPDQMLYRTT MALTVGGTIY
110
CLIALYMASQ PRNK
Length:114
Mass (Da):12,544
Last modified:October 11, 2005 - v1
Checksum:i953BC55FD65E379F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102552 mRNA. Translation: AAI02553.1.
RefSeqiNP_001029867.1. NM_001034695.2.
UniGeneiBt.49046.

Genome annotation databases

EnsembliENSBTAT00000000943; ENSBTAP00000000943; ENSBTAG00000000705.
GeneIDi540225.
KEGGibta:540225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102552 mRNA. Translation: AAI02553.1.
RefSeqiNP_001029867.1. NM_001034695.2.
UniGeneiBt.49046.

3D structure databases

ProteinModelPortaliQ3T061.
SMRiQ3T061. Positions 57-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000943.

Proteomic databases

PaxDbiQ3T061.
PeptideAtlasiQ3T061.
PRIDEiQ3T061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000943; ENSBTAP00000000943; ENSBTAG00000000705.
GeneIDi540225.
KEGGibta:540225.

Organism-specific databases

CTDi9167.

Phylogenomic databases

eggNOGiENOG410IYMH. Eukaryota.
ENOG41120Z9. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiQ3T061.
KOiK02270.
OMAiYFAAQPN.
OrthoDBiEOG7BGHNV.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
IPR017267. Cyt_c_oxidase_su7a-rel_mt.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PTHR10510:SF2. PTHR10510:SF2. 1 hit.
PIRSFiPIRSF037710. COX7A-rel_mt. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiCOX7R_BOVIN
AccessioniPrimary (citable) accession number: Q3T061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.