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Protein

Translation initiation factor eIF-2B subunit delta

Gene

EIF2B4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:EIF2B4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003173322 – 524Translation initiation factor eIF-2B subunit deltaAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei86PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T058.
PRIDEiQ3T058.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025991.

Structurei

3D structure databases

ProteinModelPortaliQ3T058.
SMRiQ3T058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1467. Eukaryota.
COG1184. LUCA.
HOGENOMiHOG000176924.
HOVERGENiHBG051459.
InParanoidiQ3T058.
KOiK03680.

Family and domain databases

InterProiView protein in InterPro
IPR000649. IF-2B-related.
IPR037171. NagB/RpiA_transferase-like.
PfamiView protein in Pfam
PF01008. IF-2B. 1 hit.
SUPFAMiSSF100950. SSF100950. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAAVAVRE DSGSGMKAEL APRPGAEGRE MTQEEKLQLR KEKKQQKKKR
60 70 80 90 100
KEEKGTETET GSAVSAAQCQ VGPAKHLAGP DSQLGTAKEK VPAGRSKAEL
110 120 130 140 150
RAERRAKQEA ERAMKQARKG DQGGPPPQAC PSTAGETPSG VKRLPEHSQV
160 170 180 190 200
DDPTLLRRLV KKPERQQVPT RKDYGSKVSL FSHLPQYSRQ NSLTQFMSIP
210 220 230 240 250
SSVIHPAMVR LGLQYSQGLV SGSNARCIAL LRALQQVIQD YTTPPSEELS
260 270 280 290 300
RDLVNKLKPY FSFLTQCRPL SASMYNAIKL LNKEITGVSG SKREEEAKSE
310 320 330 340 350
LRAAIDRYIK EKIVLAAQAI SRFAYKKISN GDVILVYGCS SLVSHILQEA
360 370 380 390 400
WAKGRQFRVV VVDSRPRLEA KHTLRSLVRA GVPASYLLIP AASYVLPEVS
410 420 430 440 450
KVLLGAHALL ANGSVMSRVG TAQLALVARA HNVPVLVCCE TYKFCERVQT
460 470 480 490 500
DAFVSNELDD PDDLLCERGE HVALANWQNH SSLRLLNLVY DVTPPELVDL
510 520
VITELGMIPC SSVPVVLRVK SSDQ
Length:524
Mass (Da):57,469
Last modified:October 11, 2005 - v1
Checksum:i78BE7BA6E1F02BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102555 mRNA. Translation: AAI02556.1.
RefSeqiNP_001029716.1. NM_001034544.2.
UniGeneiBt.48888.

Genome annotation databases

GeneIDi521926.
KEGGibta:521926.

Similar proteinsi

Entry informationi

Entry nameiEI2BD_BOVIN
AccessioniPrimary (citable) accession number: Q3T058
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families