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Protein

L-lactate dehydrogenase A-like 6B

Gene

LDHAL6B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase A-like 6B (LDHAL6B), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148NADBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei187NAD or substrateBy similarity1
Binding sitei218SubstrateBy similarity1
Active sitei242Proton acceptorBy similarity1
Binding sitei297SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase A-like 6B (EC:1.1.1.27)
Gene namesi
Name:LDHAL6B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002396531 – 381L-lactate dehydrogenase A-like 6BAdd BLAST381

Proteomic databases

PeptideAtlasiQ3T056.
PRIDEiQ3T056.

Structurei

3D structure databases

ProteinModelPortaliQ3T056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

HOVERGENiHBG000462.
InParanoidiQ3T056.
KOiK00016.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3T056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWTVGILRA SQRAGTVRAN FLCLGMAPSP CPPAATPLGG AWAVAPASKM
60 70 80 90 100
ATVKCELMKN FTSEEPVRNS KISIVGTGSV GMACAVSILL KGLSDELALV
110 120 130 140 150
DVDEGRLKGE TMDLQHGSLF VKMPNIVSSR DYVVTANSNL VIITAGARQE
160 170 180 190 200
KGETRLNLVQ RNVAIFKLMM SSIVQYSPRC KLIVVSNPVD ILTYVAWKLS
210 220 230 240 250
AFPQNRVIGS GCNLDTARFR FLIGQRLSIH SESCHGWILG EHGDSSVPVW
260 270 280 290 300
SGVNIAGVPL KELNLDIGTD KDPEQWKNVH KDVVASAYEI IKMKGYTYWA
310 320 330 340 350
IGLSVADLTE SILKNLRRVH PVSTRIKGLY GINEEVFLSV PCILGESGIT
360 370 380
DLIKVKLAPE EEARLQKSAK TLWDIQKELK F
Length:381
Mass (Da):41,592
Last modified:October 11, 2005 - v1
Checksum:iB6510C30FD480668
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102557 mRNA. Translation: AAI02558.1.
RefSeqiNP_001030352.1. NM_001035275.2.
UniGeneiBt.94959.

Genome annotation databases

GeneIDi509519.
KEGGibta:509519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102557 mRNA. Translation: AAI02558.1.
RefSeqiNP_001030352.1. NM_001035275.2.
UniGeneiBt.94959.

3D structure databases

ProteinModelPortaliQ3T056.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ3T056.
PRIDEiQ3T056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi509519.
KEGGibta:509519.

Organism-specific databases

CTDi92483.

Phylogenomic databases

HOVERGENiHBG000462.
InParanoidiQ3T056.
KOiK00016.

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDH6B_BOVIN
AccessioniPrimary (citable) accession number: Q3T056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2005
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-50 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.