Reviewed, UniProtKB/Swiss-Prot Q3T056 (LDH6B_BOVIN)

Names and origin

Protein names

Recommended name:
    L-lactate dehydrogenase A-like 6B
    EC=1.1.1.27

Gene names

Name:

LDHAL6B

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-lactate + NAD+ = pyruvate + NADH.
Pathway	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Sequence similarities	Belongs to the LDH/MDH superfamily. LDH family.
Caution	It is uncertain whether Met-1 or Met-50 is the initiator.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	anaerobic glycolysis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	L-lactate dehydrogenase A-like 6B		PRO_0000239653
Regions
	Nucleotide binding	101 – 106	6	NAD By similarity
Sites
	Active site	242	1	Proton acceptor By similarity
	Binding site	148	1	NAD By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	187	1	NAD or substrate By similarity
	Binding site	218	1	Substrate By similarity
	Binding site	297	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T056-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: B6510C30FD480668	FASTA	381	41,592
	10 20 30 40 50 60 MSWTVGILRA SQRAGTVRAN FLCLGMAPSP CPPAATPLGG AWAVAPASKM ATVKCELMKN 70 80 90 100 110 120 FTSEEPVRNS KISIVGTGSV GMACAVSILL KGLSDELALV DVDEGRLKGE TMDLQHGSLF 130 140 150 160 170 180 VKMPNIVSSR DYVVTANSNL VIITAGARQE KGETRLNLVQ RNVAIFKLMM SSIVQYSPRC 190 200 210 220 230 240 KLIVVSNPVD ILTYVAWKLS AFPQNRVIGS GCNLDTARFR FLIGQRLSIH SESCHGWILG 250 260 270 280 290 300 EHGDSSVPVW SGVNIAGVPL KELNLDIGTD KDPEQWKNVH KDVVASAYEI IKMKGYTYWA 310 320 330 340 350 360 IGLSVADLTE SILKNLRRVH PVSTRIKGLY GINEEVFLSV PCILGESGIT DLIKVKLAPE 370 380 EEARLQKSAK TLWDIQKELK F

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102557 mRNA. Translation: AAI02558.1.
IPI	IPI00686323.
RefSeq	NP_001030352.1.
UniGene	Bt.94959
3D structure databases
SMR	Q3T056. Positions 51-381.
ModBase	Search...
Genome annotation databases
GeneID	509519.
KEGG	bta:509519.
Organism-specific databases
CTD	509519.
Phylogenomic databases
HOVERGEN	Q3T056.
PhylomeDB	Q3T056.
Enzyme and pathway databases
BRENDA	1.1.1.27. 251.
Family and domain databases
InterPro	IPR001557. L-lactate/malate_DH. IPR011304. L-lactate_DH. IPR018177. L-lactate_DH_AS. IPR001236. Lactate/malate_DH. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
TIGRFAMs	TIGR01771. L-LDH-NAD. 1 hit.
PROSITE	PS00064. L_LDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LDH6B_BOVIN

Accession

Primary (citable) accession number: Q3T056

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 11, 2005
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)