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Protein

Inter-alpha-trypsin inhibitor heavy chain H4

Gene

ITIH4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.1 Publication

GO - Molecular functioni

GO - Biological processi

  • acute-phase response Source: UniProtKB
  • hyaluronan metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H4
Short name:
ITI heavy chain H4
Short name:
ITI-HC4
Short name:
Inter-alpha-inhibitor heavy chain 4
Gene namesi
Name:ITIH4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 916889Inter-alpha-trypsin inhibitor heavy chain H4PRO_0000285684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence analysis
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence analysis
Glycosylationi683 – 6831O-linked (GalNAc...)1 Publication
Glycosylationi705 – 7051O-linked (GalNAc...)1 Publication
Glycosylationi706 – 7061O-linked (GalNAc...)1 Publication
Glycosylationi708 – 7081O-linked (GalNAc...)1 Publication
Disulfide bondi733 ↔ 911By similarity

Post-translational modificationi

Appears to be both N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3T052.
PeptideAtlasiQ3T052.
PRIDEiQ3T052.

PTM databases

UniCarbKBiQ3T052.

Expressioni

Inductioni

Levels of ITIH4 in serum increase 3- to 12-fold on inoculation with various bacteria which induce mastitis. Peak levels are reached around 42h-72 h after infection.1 Publication

Interactioni

Subunit structurei

Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010330.

Structurei

3D structure databases

ProteinModelPortaliQ3T052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 149122VITPROSITE-ProRule annotationAdd
BLAST
Domaini275 – 458184VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ3T052.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPAPGRIH SIVLVLLSLA VLQTSKAQKV QNDIDIYSLT VDSKVSSRFA
60 70 80 90 100
HTVITSRVVN KADAVREATF QMELPKKAFI TNFSMVIDGV TYPGNIKEKA
110 120 130 140 150
AAQEQYSAAV ARGESAGLVR ATGRKTEQFQ VSVSVAPAAK VTFELVYEEL
160 170 180 190 200
LARHLGAYEL LLKVRPQQLV KHLQMDIHIF EPQGISFLET ESTFMTNKLA
210 220 230 240 250
EALTTSQNKT KAHVRFKPTL SQQQKYPEKQ DTVIDGSFIV RYDVDRPLSG
260 270 280 290 300
GSIQIENGYF VHYFAPDSLS TIPKNVIFVI DKSGSMMGRK IKQTREALIK
310 320 330 340 350
ILDDLSPHDQ FDLISFSSEA TTWKPLLVPA STENVNEAKS YATGIQAQGG
360 370 380 390 400
TNINDAMLMA VQLLEKANQE ELLPEGSITL IILLTDGDPT VGETNPLNIQ
410 420 430 440 450
KNVRKAINGQ HSLFCLGFGF DVSYAFLEKM ALENGGLARR IYEDSDSALQ
460 470 480 490 500
LQDFYQEVAN PLMTSVAFEY PSNAVESVTQ DTFRVFFKGS ELVVAGKLRE
510 520 530 540 550
QSPDVLLAQI RGQLHRENIT YMMMSHVAEQ EEMFRSPKYI FHSFIERLWA
560 570 580 590 600
YLTIQQLLEQ MVSALDAEKQ ALEARALSLS LSYSFVTPLT SMVITKPEGQ
610 620 630 640 650
EQSQVAEKPV EDESRGSRVY LGPMRFGHSV GDRTSRKPGG GLKLLNGTPL
660 670 680 690 700
FGPPGPPAAA SPFHRMTSRL VLPELMSPLA PASAPSPTSG PGGASHDTDF
710 720 730 740 750
RIKGTTPTAL PFAPVQAPSV ILPLPGQSVD RLCVDLRRPQ ELVNLLSDPD
760 770 780 790 800
QGVEVTGHFE TAKARFSWIE VTFENPQVQI HASPEHVVMT RNRRNSAYKW
810 820 830 840 850
KETLYSVMPG LKVTMDKEGL LLLSRPDRVT IGLLFWDGPG KGLRLLLQNT
860 870 880 890 900
DRFSSHVSGT LGQFYQDVLW GPLDTADDSK RTLKVQGRDY SATRELKLDY
910
QESPPGKEIS CWSVEL
Length:916
Mass (Da):101,513
Last modified:October 11, 2005 - v1
Checksum:iFC1AEC0745DB7086
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti390 – 3901T → D AA sequence (PubMed:15213118).Curated
Sequence conflicti397 – 3971L → S AA sequence (PubMed:15213118).Curated
Sequence conflicti411 – 4122HS → QV AA sequence (PubMed:15213118).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102561 mRNA. Translation: AAI02562.1.
RefSeqiNP_001015590.2. NM_001015590.3.
UniGeneiBt.5945.

Genome annotation databases

GeneIDi513700.
KEGGibta:513700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102561 mRNA. Translation: AAI02562.1.
RefSeqiNP_001015590.2. NM_001015590.3.
UniGeneiBt.5945.

3D structure databases

ProteinModelPortaliQ3T052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010330.

PTM databases

UniCarbKBiQ3T052.

Proteomic databases

PaxDbiQ3T052.
PeptideAtlasiQ3T052.
PRIDEiQ3T052.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi513700.
KEGGibta:513700.

Organism-specific databases

CTDi3700.

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
InParanoidiQ3T052.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITIH4_BOVIN
AccessioniPrimary (citable) accession number: Q3T052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.