ID   BDH2_BOVIN              Reviewed;         245 AA.
AC   Q3T046;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=3-hydroxybutyrate dehydrogenase type 2;
DE            EC=1.1.1.30;
DE   AltName: Full=R-beta-hydroxybutyrate dehydrogenase;
DE   AltName: Full=Dehydrogenase/reductase SDR family member 6;
GN   Name=BDH2; Synonyms=DHRS6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate
CC       + NADH.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; BC102567; AAI02568.1; -; mRNA.
DR   IPI; IPI00694312; -.
DR   RefSeq; NP_001029660.1; -.
DR   UniGene; Bt.1792; -.
DR   SMR; Q3T046; 1-245.
DR   Ensembl; ENSBTAG00000002526; Bos taurus.
DR   GeneID; 515321; -.
DR   KEGG; bta:515321; -.
DR   HOVERGEN; Q3T046; -.
DR   BRENDA; 1.1.1.30; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; IEA:EC.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase; Phosphoprotein.
FT   CHAIN         1    245       3-hydroxybutyrate dehydrogenase type 2.
FT                                /FTId=PRO_0000247551.
FT   NP_BIND      10     37       NAD (By similarity).
FT   NP_BIND     180    184       NAD (By similarity).
FT   ACT_SITE    147    147       Proton acceptor (By similarity).
FT   BINDING      58     58       NAD (By similarity).
FT   BINDING     144    144       Substrate (By similarity).
FT   BINDING     151    151       NAD (By similarity).
FT   BINDING     188    188       Substrate (By similarity).
FT   BINDING     205    205       Substrate (By similarity).
FT   MOD_RES     132    132       Phosphoserine (By similarity).
SQ   SEQUENCE   245 AA;  26662 MW;  A846933ACBA6F83C CRC64;
     MGRLDGKVIV LTAAAQGIGR AAALAFAKEG AKVIATDIND SKLQELDKYP GIHTRVLDVT
     KKKQIDQFAN DIERLDVLFN VAGFVHHGTI LDCEETDWDF SMNLNVRSMY LMIKAFLPKM
     MAQKSGNIIN MSSVASSIKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV
     DTPSLQERIQ ARPNPEEALS DFLKRQKTGR FATAEEVALL CVYLASDESA YITGNPVIID
     GGWSL
//