Reviewed, UniProtKB/Swiss-Prot Q3T046 (BDH2_BOVIN)

Names and origin

Protein names

Recommended name:
    3-hydroxybutyrate dehydrogenase type 2
    EC=1.1.1.30
Alternative name(s):
    R-beta-hydroxybutyrate dehydrogenase
    Dehydrogenase/reductase SDR family member 6

Gene names

Name:	BDH2
Synonyms:	DHRS6

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-hydroxybutyrate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	3-hydroxybutyrate dehydrogenase type 2		PRO_0000247551
Regions
	Nucleotide binding	10 – 37	28	NAD By similarity
	Nucleotide binding	180 – 184	5	NAD By similarity
Sites
	Active site	147	1	Proton acceptor By similarity
	Binding site	58	1	NAD By similarity
	Binding site	144	1	Substrate By similarity
	Binding site	151	1	NAD By similarity
	Binding site	188	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
Amino acid modifications
	Modified residue	132	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T046-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: A846933ACBA6F83C	FASTA	245	26,662
	10 20 30 40 50 60 MGRLDGKVIV LTAAAQGIGR AAALAFAKEG AKVIATDIND SKLQELDKYP GIHTRVLDVT 70 80 90 100 110 120 KKKQIDQFAN DIERLDVLFN VAGFVHHGTI LDCEETDWDF SMNLNVRSMY LMIKAFLPKM 130 140 150 160 170 180 MAQKSGNIIN MSSVASSIKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 190 200 210 220 230 240 DTPSLQERIQ ARPNPEEALS DFLKRQKTGR FATAEEVALL CVYLASDESA YITGNPVIID GGWSL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102567 mRNA. Translation: AAI02568.1.
RefSeq	NP_001029660.1.
UniGene	Bt.1792
3D structure databases
SMR	Q3T046. Positions 1-245.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000002526. Bos taurus. [Contig view]
GeneID	515321.
KEGG	bta:515321.
Phylogenomic databases
HOVERGEN	Q3T046.
Family and domain databases
InterPro	IPR002198. DHase_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BDH2_BOVIN

Accession

Primary (citable) accession number: Q3T046

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 11, 2005
Last modified:	November 4, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)