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Reviewed, UniProtKB/Swiss-Prot Q3T046 (BDH2_BOVIN)

Last modified January 19, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-hydroxybutyrate dehydrogenase type 2
    EC=1.1.1.30
Alternative name(s):
    R-beta-hydroxybutyrate dehydrogenase
    Dehydrogenase/reductase SDR family member 6
Gene names
Name: BDH2
Synonyms: DHRS6
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   PTMAcetylation
Phosphoprotein
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-hydroxybutyrate dehydrogenase activity

Inferred from electronic annotation. Source: EC

binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2452453-hydroxybutyrate dehydrogenase type 2
PRO_0000247551

Regions

Nucleotide binding10 – 3728NAD By similarity
Nucleotide binding180 – 1845NAD By similarity

Sites

Active site1471Proton acceptor By similarity
Binding site581NAD By similarity
Binding site1441Substrate By similarity
Binding site1511NAD By similarity
Binding site1881Substrate By similarity
Binding site2051Substrate By similarity

Amino acid modifications

Modified residue481N6-acetyllysine By similarity
Modified residue1321Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3T046-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: A846933ACBA6F83C

FASTA24526,662
        10         20         30         40         50         60 
MGRLDGKVIV LTAAAQGIGR AAALAFAKEG AKVIATDIND SKLQELDKYP GIHTRVLDVT 

        70         80         90        100        110        120 
KKKQIDQFAN DIERLDVLFN VAGFVHHGTI LDCEETDWDF SMNLNVRSMY LMIKAFLPKM 

       130        140        150        160        170        180 
MAQKSGNIIN MSSVASSIKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 

       190        200        210        220        230        240 
DTPSLQERIQ ARPNPEEALS DFLKRQKTGR FATAEEVALL CVYLASDESA YITGNPVIID 


GGWSL

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC102567 mRNA. Translation: AAI02568.1.
IPIIPI00694312.
RefSeqNP_001029660.1.
UniGeneBt.1792

3D structure databases

SMRQ3T046. Positions 1-245.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3T046.

Genome annotation databases

EnsemblENSBTAT00000003277; ENSBTAP00000003277; ENSBTAG00000002526; Bos taurus. [Genome view]
GeneID515321.
KEGGbta:515321.

Organism-specific databases

CTD515321.

Phylogenomic databases

eggNOGmaNOG04096.
HOVERGENQ3T046.
PhylomeDBQ3T046.

Enzyme and pathway databases

BRENDA1.1.1.30. 251.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBDH2_BOVIN
AccessionPrimary (citable) accession number: Q3T046
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 11, 2005
Last modified: January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents