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Q3T035

- ARPC3_BOVIN

UniProt

Q3T035 - ARPC3_BOVIN

Protein

Actin-related protein 2/3 complex subunit 3

Gene

ARPC3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

    GO - Biological processi

    1. Arp2/3 complex-mediated actin nucleation Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.
    REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Actin-related protein 2/3 complex subunit 3
    Alternative name(s):
    Arp2/3 complex 21 kDa subunit
    Short name:
    p21-ARC
    Gene namesi
    Name:ARPC3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cell projection By similarity

    GO - Cellular componenti

    1. Arp2/3 protein complex Source: InterPro
    2. cytosol Source: Reactome
    3. lamellipodium Source: Ensembl

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 178177Actin-related protein 2/3 complex subunit 3PRO_0000246171Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471PhosphotyrosineBy similarity
    Modified residuei56 – 561N6-acetyllysineBy similarity
    Modified residuei61 – 611N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ3T035.
    PRIDEiQ3T035.

    Interactioni

    Subunit structurei

    Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Protein-protein interaction databases

    DIPiDIP-29793N.
    STRINGi9913.ENSBTAP00000007028.

    Structurei

    Secondary structure

    1
    178
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi14 – 163
    Beta strandi19 – 213
    Beta strandi36 – 383
    Helixi41 – 5212
    Helixi63 – 8220
    Helixi88 – 10013
    Turni112 – 1165
    Helixi123 – 14826
    Beta strandi151 – 1544
    Helixi158 – 1614
    Turni162 – 1654
    Helixi168 – 1703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K8KX-ray2.00E1-178[»]
    1TYQX-ray2.55E1-178[»]
    1U2VX-ray2.55E1-178[»]
    2P9IX-ray2.46E1-178[»]
    2P9KX-ray2.59E1-178[»]
    2P9LX-ray2.65E1-178[»]
    2P9NX-ray2.85E1-178[»]
    2P9PX-ray2.90E1-178[»]
    2P9SX-ray2.68E1-178[»]
    2P9UX-ray2.75E1-178[»]
    3DXKX-ray2.70E1-178[»]
    3DXMX-ray2.85E1-178[»]
    3RSEX-ray2.65E1-178[»]
    3UKRX-ray2.48E1-178[»]
    3UKUX-ray2.75E1-178[»]
    3ULEX-ray2.50E1-178[»]
    4JD2X-ray3.08E1-178[»]
    ProteinModelPortaliQ3T035.
    SMRiQ3T035. Positions 2-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ3T035.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ARPC3 family.Curated

    Phylogenomic databases

    eggNOGiNOG324671.
    GeneTreeiENSGT00390000018018.
    HOGENOMiHOG000161465.
    HOVERGENiHBG050581.
    InParanoidiQ3T035.
    KOiK05756.
    OMAiTGKPSKW.
    OrthoDBiEOG7BS4BV.
    TreeFamiTF314598.

    Family and domain databases

    Gene3Di1.10.1760.10. 1 hit.
    InterProiIPR007204. ARP2/3_p21-Arc.
    [Graphical view]
    PANTHERiPTHR12391. PTHR12391. 1 hit.
    PfamiPF04062. P21-Arc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016315. ARP2/3_P21-Arc. 1 hit.
    SUPFAMiSSF69060. SSF69060. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3T035-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK    50
    ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI 100
    TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD 150
    PQNDKPSKWW TCFVKRQFMN KSLSGPGQ 178
    Length:178
    Mass (Da):20,547
    Last modified:January 23, 2007 - v3
    Checksum:i7149F598B48F0EAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102590 mRNA. Translation: AAI02591.1.
    RefSeqiNP_001029443.1. NM_001034271.2.
    UniGeneiBt.59092.

    Genome annotation databases

    EnsembliENSBTAT00000007028; ENSBTAP00000007028; ENSBTAG00000005345.
    GeneIDi506596.
    KEGGibta:506596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102590 mRNA. Translation: AAI02591.1 .
    RefSeqi NP_001029443.1. NM_001034271.2.
    UniGenei Bt.59092.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K8K X-ray 2.00 E 1-178 [» ]
    1TYQ X-ray 2.55 E 1-178 [» ]
    1U2V X-ray 2.55 E 1-178 [» ]
    2P9I X-ray 2.46 E 1-178 [» ]
    2P9K X-ray 2.59 E 1-178 [» ]
    2P9L X-ray 2.65 E 1-178 [» ]
    2P9N X-ray 2.85 E 1-178 [» ]
    2P9P X-ray 2.90 E 1-178 [» ]
    2P9S X-ray 2.68 E 1-178 [» ]
    2P9U X-ray 2.75 E 1-178 [» ]
    3DXK X-ray 2.70 E 1-178 [» ]
    3DXM X-ray 2.85 E 1-178 [» ]
    3RSE X-ray 2.65 E 1-178 [» ]
    3UKR X-ray 2.48 E 1-178 [» ]
    3UKU X-ray 2.75 E 1-178 [» ]
    3ULE X-ray 2.50 E 1-178 [» ]
    4JD2 X-ray 3.08 E 1-178 [» ]
    ProteinModelPortali Q3T035.
    SMRi Q3T035. Positions 2-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29793N.
    STRINGi 9913.ENSBTAP00000007028.

    Proteomic databases

    PaxDbi Q3T035.
    PRIDEi Q3T035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000007028 ; ENSBTAP00000007028 ; ENSBTAG00000005345 .
    GeneIDi 506596.
    KEGGi bta:506596.

    Organism-specific databases

    CTDi 10094.

    Phylogenomic databases

    eggNOGi NOG324671.
    GeneTreei ENSGT00390000018018.
    HOGENOMi HOG000161465.
    HOVERGENi HBG050581.
    InParanoidi Q3T035.
    KOi K05756.
    OMAi TGKPSKW.
    OrthoDBi EOG7BS4BV.
    TreeFami TF314598.

    Enzyme and pathway databases

    Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.
    REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

    Miscellaneous databases

    EvolutionaryTracei Q3T035.
    NextBioi 20867671.

    Family and domain databases

    Gene3Di 1.10.1760.10. 1 hit.
    InterProi IPR007204. ARP2/3_p21-Arc.
    [Graphical view ]
    PANTHERi PTHR12391. PTHR12391. 1 hit.
    Pfami PF04062. P21-Arc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016315. ARP2/3_P21-Arc. 1 hit.
    SUPFAMi SSF69060. SSF69060. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
    3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
      Nolen B.J., Littlefield R.S., Pollard T.D.
      Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

    Entry informationi

    Entry nameiARPC3_BOVIN
    AccessioniPrimary (citable) accession number: Q3T035
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3