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Protein

Actin-related protein 2/3 complex subunit 3

Gene

ARPC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-BTA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-BTA-3928662. EPHB-mediated forward signaling.
R-BTA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-BTA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:ARPC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: InterPro
  • cell projection Source: UniProtKB-SubCell
  • cytoplasm Source: AgBase
  • cytosol Source: Reactome

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002461711 – 178Actin-related protein 2/3 complex subunit 3Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei47PhosphotyrosineBy similarity1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei61N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3T035.
PeptideAtlasiQ3T035.
PRIDEiQ3T035.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005345.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29793N.
STRINGi9913.ENSBTAP00000007028.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 16Combined sources3
Beta strandi19 – 21Combined sources3
Beta strandi36 – 38Combined sources3
Helixi41 – 52Combined sources12
Helixi63 – 82Combined sources20
Helixi88 – 100Combined sources13
Turni112 – 116Combined sources5
Helixi123 – 148Combined sources26
Beta strandi151 – 154Combined sources4
Helixi158 – 161Combined sources4
Turni162 – 165Combined sources4
Helixi168 – 170Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00E1-178[»]
1TYQX-ray2.55E1-178[»]
1U2VX-ray2.55E1-178[»]
2P9IX-ray2.46E1-178[»]
2P9KX-ray2.59E1-178[»]
2P9LX-ray2.65E1-178[»]
2P9NX-ray2.85E1-178[»]
2P9PX-ray2.90E1-178[»]
2P9SX-ray2.68E1-178[»]
2P9UX-ray2.75E1-178[»]
3DXKX-ray2.70E1-178[»]
3DXMX-ray2.85E1-178[»]
3RSEX-ray2.65E1-178[»]
3UKRX-ray2.48E1-178[»]
3UKUX-ray2.75E1-178[»]
3ULEX-ray2.50E1-178[»]
4JD2X-ray3.08E1-178[»]
4XEIX-ray3.87E1-178[»]
4XF2X-ray5.00E/X1-178[»]
ProteinModelPortaliQ3T035.
SMRiQ3T035.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3T035.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiKOG3155. Eukaryota.
ENOG4111FTG. LUCA.
GeneTreeiENSGT00390000018018.
HOGENOMiHOG000161465.
HOVERGENiHBG050581.
InParanoidiQ3T035.
KOiK05756.
OMAiKWWLSFT.
OrthoDBiEOG091G0OUM.
TreeFamiTF314598.

Family and domain databases

Gene3Di1.10.1760.10. 1 hit.
InterProiView protein in InterPro
IPR007204. ARPC3.
PANTHERiPTHR12391. PTHR12391. 1 hit.
PfamiView protein in Pfam
PF04062. P21-Arc. 1 hit.
PIRSFiPIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMiSSF69060. SSF69060. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3T035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD
160 170
PQNDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,547
Last modified:January 23, 2007 - v3
Checksum:i7149F598B48F0EAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102590 mRNA. Translation: AAI02591.1.
RefSeqiNP_001029443.1. NM_001034271.2.
UniGeneiBt.59092.

Genome annotation databases

EnsembliENSBTAT00000007028; ENSBTAP00000007028; ENSBTAG00000005345.
GeneIDi506596.
KEGGibta:506596.

Similar proteinsi

Entry informationi

Entry nameiARPC3_BOVIN
AccessioniPrimary (citable) accession number: Q3T035
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families