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Q3T035

- ARPC3_BOVIN

UniProt

Q3T035 - ARPC3_BOVIN

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Protein

Actin-related protein 2/3 complex subunit 3

Gene

ARPC3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:ARPC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity

GO - Cellular componenti

  1. Arp2/3 protein complex Source: InterPro
  2. cell projection Source: UniProtKB-KW
  3. cytosol Source: Reactome
  4. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 178177Actin-related protein 2/3 complex subunit 3PRO_0000246171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471PhosphotyrosineBy similarity
Modified residuei56 – 561N6-acetyllysineBy similarity
Modified residuei61 – 611N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T035.
PRIDEiQ3T035.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29793N.
STRINGi9913.ENSBTAP00000007028.

Structurei

Secondary structure

1
178
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 163
Beta strandi19 – 213
Beta strandi36 – 383
Helixi41 – 5212
Helixi63 – 8220
Helixi88 – 10013
Turni112 – 1165
Helixi123 – 14826
Beta strandi151 – 1544
Helixi158 – 1614
Turni162 – 1654
Helixi168 – 1703

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00E1-178[»]
1TYQX-ray2.55E1-178[»]
1U2VX-ray2.55E1-178[»]
2P9IX-ray2.46E1-178[»]
2P9KX-ray2.59E1-178[»]
2P9LX-ray2.65E1-178[»]
2P9NX-ray2.85E1-178[»]
2P9PX-ray2.90E1-178[»]
2P9SX-ray2.68E1-178[»]
2P9UX-ray2.75E1-178[»]
3DXKX-ray2.70E1-178[»]
3DXMX-ray2.85E1-178[»]
3RSEX-ray2.65E1-178[»]
3UKRX-ray2.48E1-178[»]
3UKUX-ray2.75E1-178[»]
3ULEX-ray2.50E1-178[»]
4JD2X-ray3.08E1-178[»]
ProteinModelPortaliQ3T035.
SMRiQ3T035. Positions 2-175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3T035.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.Curated

Phylogenomic databases

eggNOGiNOG324671.
GeneTreeiENSGT00390000018018.
HOGENOMiHOG000161465.
HOVERGENiHBG050581.
InParanoidiQ3T035.
KOiK05756.
OMAiTGKPSKW.
OrthoDBiEOG7BS4BV.
TreeFamiTF314598.

Family and domain databases

Gene3Di1.10.1760.10. 1 hit.
InterProiIPR007204. ARP2/3_p21-Arc.
[Graphical view]
PANTHERiPTHR12391. PTHR12391. 1 hit.
PfamiPF04062. P21-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMiSSF69060. SSF69060. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T035-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK
60 70 80 90 100
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI
110 120 130 140 150
TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD
160 170
PQNDKPSKWW TCFVKRQFMN KSLSGPGQ
Length:178
Mass (Da):20,547
Last modified:January 23, 2007 - v3
Checksum:i7149F598B48F0EAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102590 mRNA. Translation: AAI02591.1.
RefSeqiNP_001029443.1. NM_001034271.2.
UniGeneiBt.59092.

Genome annotation databases

EnsembliENSBTAT00000007028; ENSBTAP00000007028; ENSBTAG00000005345.
GeneIDi506596.
KEGGibta:506596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102590 mRNA. Translation: AAI02591.1 .
RefSeqi NP_001029443.1. NM_001034271.2.
UniGenei Bt.59092.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 E 1-178 [» ]
1TYQ X-ray 2.55 E 1-178 [» ]
1U2V X-ray 2.55 E 1-178 [» ]
2P9I X-ray 2.46 E 1-178 [» ]
2P9K X-ray 2.59 E 1-178 [» ]
2P9L X-ray 2.65 E 1-178 [» ]
2P9N X-ray 2.85 E 1-178 [» ]
2P9P X-ray 2.90 E 1-178 [» ]
2P9S X-ray 2.68 E 1-178 [» ]
2P9U X-ray 2.75 E 1-178 [» ]
3DXK X-ray 2.70 E 1-178 [» ]
3DXM X-ray 2.85 E 1-178 [» ]
3RSE X-ray 2.65 E 1-178 [» ]
3UKR X-ray 2.48 E 1-178 [» ]
3UKU X-ray 2.75 E 1-178 [» ]
3ULE X-ray 2.50 E 1-178 [» ]
4JD2 X-ray 3.08 E 1-178 [» ]
ProteinModelPortali Q3T035.
SMRi Q3T035. Positions 2-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29793N.
STRINGi 9913.ENSBTAP00000007028.

Proteomic databases

PaxDbi Q3T035.
PRIDEi Q3T035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007028 ; ENSBTAP00000007028 ; ENSBTAG00000005345 .
GeneIDi 506596.
KEGGi bta:506596.

Organism-specific databases

CTDi 10094.

Phylogenomic databases

eggNOGi NOG324671.
GeneTreei ENSGT00390000018018.
HOGENOMi HOG000161465.
HOVERGENi HBG050581.
InParanoidi Q3T035.
KOi K05756.
OMAi TGKPSKW.
OrthoDBi EOG7BS4BV.
TreeFami TF314598.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei Q3T035.
NextBioi 20867671.

Family and domain databases

Gene3Di 1.10.1760.10. 1 hit.
InterProi IPR007204. ARP2/3_p21-Arc.
[Graphical view ]
PANTHERi PTHR12391. PTHR12391. 1 hit.
Pfami PF04062. P21-Arc. 1 hit.
[Graphical view ]
PIRSFi PIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMi SSF69060. SSF69060. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARPC3_BOVIN
AccessioniPrimary (citable) accession number: Q3T035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3