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Q3T035 (ARPC3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name=p21-ARC
Gene names
Name:ARPC3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

Subunit structure

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Subcellular location

Cytoplasm › cytoskeleton By similarity. Cell projection By similarity.

Sequence similarities

Belongs to the ARPC3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 178177Actin-related protein 2/3 complex subunit 3
PRO_0000246171

Amino acid modifications

Modified residue471Phosphotyrosine By similarity
Modified residue561N6-acetyllysine By similarity
Modified residue611N6-acetyllysine By similarity

Secondary structure

1 ........................ 178
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q3T035 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 7149F598B48F0EAC

FASTA17820,547
        10         20         30         40         50         60 
MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI 

        70         80         90        100        110        120 
KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP 

       130        140        150        160        170 
ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[2]"Crystal structure of Arp2/3 complex."
Robinson R.C., Turbedsky K., Kaiser D.A., Marchand J.-B., Higgs H.N., Choe S., Pollard T.D.
Science 294:1679-1684(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
[3]"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
Nolen B.J., Littlefield R.S., Pollard T.D.
Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC102590 mRNA. Translation: AAI02591.1.
IPIIPI00711750.
RefSeqNP_001029443.1. NM_001034271.2.
UniGeneBt.59092.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00E1-178[»]
1TYQX-ray2.55E1-178[»]
1U2VX-ray2.55E1-178[»]
2P9IX-ray2.46E1-178[»]
2P9KX-ray2.59E1-178[»]
2P9LX-ray2.65E1-178[»]
2P9NX-ray2.85E1-178[»]
2P9PX-ray2.90E1-178[»]
2P9SX-ray2.68E1-178[»]
2P9UX-ray2.75E1-178[»]
3DXKX-ray2.70E1-178[»]
3DXMX-ray2.85E1-178[»]
3RSEX-ray2.65E1-178[»]
3UKRX-ray2.48E1-178[»]
3UKUX-ray2.75E1-178[»]
3ULEX-ray2.50E1-178[»]
ProteinModelPortalQ3T035.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29793N.
STRING9913.ENSBTAP00000007028.

Proteomic databases

PaxDbQ3T035.
PRIDEQ3T035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000007028; ENSBTAP00000007028; ENSBTAG00000005345.
GeneID506596.
KEGGbta:506596.

Organism-specific databases

CTD10094.

Phylogenomic databases

eggNOGNOG324671.
GeneTreeENSGT00390000018018.
HOGENOMHOG000161465.
HOVERGENHBG050581.
InParanoidQ3T035.
KOK05756.
OMAFRTYEIK.
OrthoDBEOG4K0QPG.

Family and domain databases

Gene3D1.10.1760.10. 1 hit.
InterProIPR007204. ARP2/3_p21-Arc.
[Graphical view]
PANTHERPTHR12391. PTHR12391. 1 hit.
PfamPF04062. P21-Arc. 1 hit.
[Graphical view]
PIRSFPIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMSSF69060. ARP2/3_P21-Arc. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ3T035.
NextBio20867671.

Entry information

Entry nameARPC3_BOVIN
AccessionPrimary (citable) accession number: Q3T035
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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