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Q3T035

- ARPC3_BOVIN

UniProt

Q3T035 - ARPC3_BOVIN

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Protein
Actin-related protein 2/3 complex subunit 3
Gene
ARPC3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 3
Alternative name(s):
Arp2/3 complex 21 kDa subunit
Short name:
p21-ARC
Gene namesi
Name:ARPC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity

GO - Cellular componenti

  1. Arp2/3 protein complex Source: InterPro
  2. cytosol Source: Reactome
  3. lamellipodium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 178177Actin-related protein 2/3 complex subunit 3
PRO_0000246171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471Phosphotyrosine By similarity
Modified residuei56 – 561N6-acetyllysine By similarity
Modified residuei61 – 611N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T035.
PRIDEiQ3T035.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Protein-protein interaction databases

DIPiDIP-29793N.
STRINGi9913.ENSBTAP00000007028.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 163
Beta strandi19 – 213
Beta strandi36 – 383
Helixi41 – 5212
Helixi63 – 8220
Helixi88 – 10013
Turni112 – 1165
Helixi123 – 14826
Beta strandi151 – 1544
Helixi158 – 1614
Turni162 – 1654
Helixi168 – 1703

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00E1-178[»]
1TYQX-ray2.55E1-178[»]
1U2VX-ray2.55E1-178[»]
2P9IX-ray2.46E1-178[»]
2P9KX-ray2.59E1-178[»]
2P9LX-ray2.65E1-178[»]
2P9NX-ray2.85E1-178[»]
2P9PX-ray2.90E1-178[»]
2P9SX-ray2.68E1-178[»]
2P9UX-ray2.75E1-178[»]
3DXKX-ray2.70E1-178[»]
3DXMX-ray2.85E1-178[»]
3RSEX-ray2.65E1-178[»]
3UKRX-ray2.48E1-178[»]
3UKUX-ray2.75E1-178[»]
3ULEX-ray2.50E1-178[»]
4JD2X-ray3.08E1-178[»]
ProteinModelPortaliQ3T035.
SMRiQ3T035. Positions 2-175.

Miscellaneous databases

EvolutionaryTraceiQ3T035.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC3 family.

Phylogenomic databases

eggNOGiNOG324671.
GeneTreeiENSGT00390000018018.
HOGENOMiHOG000161465.
HOVERGENiHBG050581.
InParanoidiQ3T035.
KOiK05756.
OMAiTGKPSKW.
OrthoDBiEOG7BS4BV.
TreeFamiTF314598.

Family and domain databases

Gene3Di1.10.1760.10. 1 hit.
InterProiIPR007204. ARP2/3_p21-Arc.
[Graphical view]
PANTHERiPTHR12391. PTHR12391. 1 hit.
PfamiPF04062. P21-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMiSSF69060. SSF69060. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T035-1 [UniParc]FASTAAdd to Basket

« Hide

MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK    50
ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI 100
TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD 150
PQNDKPSKWW TCFVKRQFMN KSLSGPGQ 178
Length:178
Mass (Da):20,547
Last modified:January 23, 2007 - v3
Checksum:i7149F598B48F0EAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102590 mRNA. Translation: AAI02591.1.
RefSeqiNP_001029443.1. NM_001034271.2.
UniGeneiBt.59092.

Genome annotation databases

EnsembliENSBTAT00000007028; ENSBTAP00000007028; ENSBTAG00000005345.
GeneIDi506596.
KEGGibta:506596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102590 mRNA. Translation: AAI02591.1 .
RefSeqi NP_001029443.1. NM_001034271.2.
UniGenei Bt.59092.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 E 1-178 [» ]
1TYQ X-ray 2.55 E 1-178 [» ]
1U2V X-ray 2.55 E 1-178 [» ]
2P9I X-ray 2.46 E 1-178 [» ]
2P9K X-ray 2.59 E 1-178 [» ]
2P9L X-ray 2.65 E 1-178 [» ]
2P9N X-ray 2.85 E 1-178 [» ]
2P9P X-ray 2.90 E 1-178 [» ]
2P9S X-ray 2.68 E 1-178 [» ]
2P9U X-ray 2.75 E 1-178 [» ]
3DXK X-ray 2.70 E 1-178 [» ]
3DXM X-ray 2.85 E 1-178 [» ]
3RSE X-ray 2.65 E 1-178 [» ]
3UKR X-ray 2.48 E 1-178 [» ]
3UKU X-ray 2.75 E 1-178 [» ]
3ULE X-ray 2.50 E 1-178 [» ]
4JD2 X-ray 3.08 E 1-178 [» ]
ProteinModelPortali Q3T035.
SMRi Q3T035. Positions 2-175.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-29793N.
STRINGi 9913.ENSBTAP00000007028.

Proteomic databases

PaxDbi Q3T035.
PRIDEi Q3T035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007028 ; ENSBTAP00000007028 ; ENSBTAG00000005345 .
GeneIDi 506596.
KEGGi bta:506596.

Organism-specific databases

CTDi 10094.

Phylogenomic databases

eggNOGi NOG324671.
GeneTreei ENSGT00390000018018.
HOGENOMi HOG000161465.
HOVERGENi HBG050581.
InParanoidi Q3T035.
KOi K05756.
OMAi TGKPSKW.
OrthoDBi EOG7BS4BV.
TreeFami TF314598.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei Q3T035.
NextBioi 20867671.

Family and domain databases

Gene3Di 1.10.1760.10. 1 hit.
InterProi IPR007204. ARP2/3_p21-Arc.
[Graphical view ]
PANTHERi PTHR12391. PTHR12391. 1 hit.
Pfami PF04062. P21-Arc. 1 hit.
[Graphical view ]
PIRSFi PIRSF016315. ARP2/3_P21-Arc. 1 hit.
SUPFAMi SSF69060. SSF69060. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARPC3_BOVIN
AccessioniPrimary (citable) accession number: Q3T035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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