Q3T013 (BNI3L_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Gene names

Name:

BNIP3L

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor By similarity.
Subunit structure	Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP By similarity.
Subcellular location	Nucleus envelope By similarity. Endoplasmic reticulum By similarity. Mitochondrion outer membrane By similarity. Membrane; Single-pass membrane protein Potential.
Post-translational modification	Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin By similarity.
Sequence similarities	Belongs to the NIP3 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Endoplasmic reticulum Membrane Mitochondrion Mitochondrion outer membrane Nucleus
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW defense response to virus Inferred from sequence or structural similarity. Source: UniProtKB induction of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB mitochondrial protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of survival gene product expression Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from sequence or structural similarity. Source: UniProtKB nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like		PRO_0000269188
Regions
	Transmembrane	187 – 207	21	Helical; Potential
Amino acid modifications
	Modified residue	62	1	Phosphoserine By similarity
	Modified residue	63	1	Phosphoserine By similarity
	Modified residue	117	1	Phosphoserine By similarity
	Modified residue	118	1	Phosphoserine By similarity
	Modified residue	120	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3T013 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: D4EB055BDB198BA6	FASTA	219	23,846
	10 20 30 40 50 60 MSSHLVEQPP PPHNNNNNCE EGEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV 70 80 90 100 110 120 PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSKDHSSQS 130 140 150 160 170 180 EEEVAEGEKE VDALKKSVDW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI 190 200 210 FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT030544 mRNA. Translation: ABQ12984.1. BC102612 mRNA. Translation: AAI02613.1.
IPI	IPI00708364.
RefSeq	NP_001029786.1. NM_001034614.1.
UniGene	Bt.888.
3D structure databases
ProteinModelPortal	Q3T013.
SMR	Q3T013. Positions 170-213.
ModBase	Search...
Proteomic databases
PRIDE	Q3T013.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000033862; ENSBTAP00000033770; ENSBTAG00000021307.
GeneID	534615.
KEGG	bta:534615.
Organism-specific databases
CTD	665.
Phylogenomic databases
eggNOG	maNOG16078.
GeneTree	ENSGT00390000013415.
HOVERGEN	HBG050707.
InParanoid	Q3T013.
OMA	LFISHVL.
OrthoDB	EOG4Q2DGM.
Family and domain databases
InterPro	IPR010548. BNIP3. [Graphical view]
KO	K15465.
Pfam	PF06553. BNIP3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BNI3L_BOVIN

Accession

Primary (citable) accession number: Q3T013
Secondary accession number(s): A5D9C5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program