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Reviewed, UniProtKB/Swiss-Prot Q3T001 (H17B6_BOVIN)

Last modified June 16, 2009. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hydroxysteroid 17-beta dehydrogenase 6
    EC=1.1.1.62
    EC=1.1.1.63
    EC=1.1.1.105
Alternative name(s):
    17-beta-HSD6
    Oxidative 3-alpha hydroxysteroid dehydrogenase
    3-alpha->beta-hydroxysteroid epimerase
      Short name=3-alpha->beta-HSE
Gene names
Name: HSD17B6
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids By similarity.

Catalytic activity

Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H.

Testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.

Retinol + NAD+ = retinal + NADH.

Subcellular location

Microsome membrane; Peripheral membrane protein; Lumenal side By similarity. Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 317300Hydroxysteroid 17-beta dehydrogenase 6
PRO_0000303210

Regions

Nucleotide binding33 – 5725NAD By similarity

Sites

Active site1761Proton acceptor By similarity
Binding site1641Substrate Potential

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q3T001-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 4B1A2ED7906FBB12

FASTA31736,198
        10         20         30         40         50         60 
MWLYLAVLLG LYYLLRWFRE RQVVSHLQDK FVFITGCDSG FGNQLARQLD LRGLRVLAGC 

        70         80         90        100        110        120 
LTEQGAEQLR NQTSDRLQTV ILDVTKTESI AAATEWVKEC VGDRGLWGLV NNAGIFHSHG 

       130        140        150        160        170        180 
YAEWIKIETY RDTLRVNLIG VIEVTLSMLP LVRKAQGRIV NVSSILGRIA FFGAVYSCSK 

       190        200        210        220        230        240 
YGVEAFSDIL RRELQHFGVK VSMVEPGYFR TAMTDWQKFS EIMKQIWKET PAHIKETYGQ 

       250        260        270        280        290        300 
KFFDAYHDLM KQGLLSCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAQFF FVPLSYLPTS 

       310 
LADYILTRSW PKPAQAV

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Testis.

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Cross-references

Sequence databases

BC102626 mRNA. Translation: AAI02627.1.
IPIIPI00716164.
RefSeqNP_001030472.1.
UniGeneBt.16385

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000011720. Bos taurus. [Contig view]
GeneID533086.
KEGGbta:533086.

Phylogenomic databases

HOVERGENQ3T001.

Enzyme and pathway databases

BRENDA1.1.1.105. 251.
1.1.1.62. 251.
1.1.1.63. 251.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameH17B6_BOVIN
AccessionPrimary (citable) accession number: Q3T001
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents