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Protein

17-beta-hydroxysteroid dehydrogenase type 6

Gene

HSD17B6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity).By similarity

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Testosterone + NAD+ = androstenedione + NADH.
All-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateSequence analysis1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 57NADBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase type 6 (EC:1.1.1.105, EC:1.1.1.239, EC:1.1.1.62)
Short name:
17-beta-HSD 6
Short name:
17-beta-HSD6
Alternative name(s):
3-alpha->beta-hydroxysteroid epimerase
Short name:
3-alpha->beta-HSE
Oxidative 3-alpha hydroxysteroid dehydrogenase
Gene namesi
Name:HSD17B6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000030321018 – 31717-beta-hydroxysteroid dehydrogenase type 6Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3T001
PeptideAtlasiQ3T001
PRIDEiQ3T001

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015564

Structurei

3D structure databases

ProteinModelPortaliQ3T001
SMRiQ3T001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
HOVERGENiHBG005482
InParanoidiQ3T001
KOiK13369

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLYLAVLLG LYYLLRWFRE RQVVSHLQDK FVFITGCDSG FGNQLARQLD
60 70 80 90 100
LRGLRVLAGC LTEQGAEQLR NQTSDRLQTV ILDVTKTESI AAATEWVKEC
110 120 130 140 150
VGDRGLWGLV NNAGIFHSHG YAEWIKIETY RDTLRVNLIG VIEVTLSMLP
160 170 180 190 200
LVRKAQGRIV NVSSILGRIA FFGAVYSCSK YGVEAFSDIL RRELQHFGVK
210 220 230 240 250
VSMVEPGYFR TAMTDWQKFS EIMKQIWKET PAHIKETYGQ KFFDAYHDLM
260 270 280 290 300
KQGLLSCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAQFF FVPLSYLPTS
310
LADYILTRSW PKPAQAV
Length:317
Mass (Da):36,198
Last modified:October 11, 2005 - v1
Checksum:i4B1A2ED7906FBB12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102626 mRNA Translation: AAI02627.1
RefSeqiNP_001030472.1, NM_001035395.2
UniGeneiBt.16385

Genome annotation databases

GeneIDi533086
KEGGibta:533086

Similar proteinsi

Entry informationi

Entry nameiH17B6_BOVIN
AccessioniPrimary (citable) accession number: Q3T001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health