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Protein

Synaptobrevin homolog YKT6

Gene

YKT6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog YKT6 (EC:2.3.1.-)
Gene namesi
Name:YKT6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807081 – 195Synaptobrevin homolog YKT6Add BLAST195
PropeptideiPRO_0000396660196 – 198Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1
Lipidationi194S-palmitoyl cysteineBy similarity1
Modified residuei195Cysteine methyl esterBy similarity1
Lipidationi195S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting (By similarity).By similarity
Farnesylation is required for Golgi targeting.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ3T000.
PRIDEiQ3T000.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000274.

Interactioni

Subunit structurei

Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000341.

Structurei

3D structure databases

ProteinModelPortaliQ3T000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 131LonginPROSITE-ProRule annotationAdd BLAST124
Domaini138 – 198v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Domaini

The longin domain regulates palmitoylation and membrane targeting.By similarity

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0861. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00390000015164.
HOGENOMiHOG000189970.
HOVERGENiHBG088939.
InParanoidiQ3T000.
KOiK08516.
OMAiGNQSKAF.
OrthoDBiEOG091G0MPE.
TreeFamiTF105606.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYSLSVLY KGESKTVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER
60 70 80 90 100
SAKGSRASVK EQEYLCHVYV RNDSLAGVVI ADSEYPSRVA FTLLEKVLDE
110 120 130 140 150
FSKQVDRIDW PTGSPDTIRY SGLDSQLSRY QNPREADPMT KVQAELDETK
160 170 180 190
IILHNTMESL LERGEKLDDL VSKSEVLGIQ SKAFYKTARK QNSCCAIM
Length:198
Mass (Da):22,467
Last modified:October 11, 2005 - v1
Checksum:i73F331ED76ED0E33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102627 mRNA. Translation: AAI02628.1.
RefSeqiNP_001030219.1. NM_001035047.1.
UniGeneiBt.87353.

Genome annotation databases

EnsembliENSBTAT00000000341; ENSBTAP00000000341; ENSBTAG00000000274.
GeneIDi507409.
KEGGibta:507409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102627 mRNA. Translation: AAI02628.1.
RefSeqiNP_001030219.1. NM_001035047.1.
UniGeneiBt.87353.

3D structure databases

ProteinModelPortaliQ3T000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000341.

Proteomic databases

PaxDbiQ3T000.
PRIDEiQ3T000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000341; ENSBTAP00000000341; ENSBTAG00000000274.
GeneIDi507409.
KEGGibta:507409.

Organism-specific databases

CTDi10652.

Phylogenomic databases

eggNOGiKOG0861. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00390000015164.
HOGENOMiHOG000189970.
HOVERGENiHBG088939.
InParanoidiQ3T000.
KOiK08516.
OMAiGNQSKAF.
OrthoDBiEOG091G0MPE.
TreeFamiTF105606.

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811438. Intra-Golgi traffic.

Gene expression databases

BgeeiENSBTAG00000000274.

Family and domain databases

Gene3Di3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYKT6_BOVIN
AccessioniPrimary (citable) accession number: Q3T000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.