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Protein

Synaptobrevin homolog YKT6

Gene

YKT6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport
R-BTA-6807878 COPI-mediated anterograde transport
R-BTA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog YKT6 (EC:2.3.1.-)
Gene namesi
Name:YKT6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:37030 YKT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807081 – 195Synaptobrevin homolog YKT6Add BLAST195
PropeptideiPRO_0000396660196 – 198Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1
Lipidationi194S-palmitoyl cysteineBy similarity1
Modified residuei195Cysteine methyl esterBy similarity1
Lipidationi195S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.By similarity
Farnesylation is required for Golgi targeting.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ3T000
PRIDEiQ3T000

Expressioni

Gene expression databases

BgeeiENSBTAG00000000274

Interactioni

Subunit structurei

Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000341

Structurei

3D structure databases

ProteinModelPortaliQ3T000
SMRiQ3T000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 131LonginPROSITE-ProRule annotationAdd BLAST124
Domaini138 – 198v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Domaini

The longin domain regulates palmitoylation and membrane targeting.By similarity

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0861 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00390000015164
HOGENOMiHOG000189970
HOVERGENiHBG088939
InParanoidiQ3T000
KOiK08516
OMAiYPVRPAF
OrthoDBiEOG091G0MPE
TreeFamiTF105606

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYSLSVLY KGESKTVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER
60 70 80 90 100
SAKGSRASVK EQEYLCHVYV RNDSLAGVVI ADSEYPSRVA FTLLEKVLDE
110 120 130 140 150
FSKQVDRIDW PTGSPDTIRY SGLDSQLSRY QNPREADPMT KVQAELDETK
160 170 180 190
IILHNTMESL LERGEKLDDL VSKSEVLGIQ SKAFYKTARK QNSCCAIM
Length:198
Mass (Da):22,467
Last modified:October 11, 2005 - v1
Checksum:i73F331ED76ED0E33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102627 mRNA Translation: AAI02628.1
RefSeqiNP_001030219.1, NM_001035047.1
UniGeneiBt.87353

Genome annotation databases

EnsembliENSBTAT00000000341; ENSBTAP00000000341; ENSBTAG00000000274
GeneIDi507409
KEGGibta:507409

Similar proteinsi

Entry informationi

Entry nameiYKT6_BOVIN
AccessioniPrimary (citable) accession number: Q3T000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health